Spectrophotometric Determination of Bezafibrate by Ternary Complex Formation with Palladium(II) Chloride and Eosin

Abstract

A simple spectrophotometric method for the determination of bezafibrate (BZF) is described. The procedure is based on the ternary complex formation between an investigated drug, palladium(II) ion, and eosin in buffered medium and in the presence of methyl cellulose as a surfactant. The composition of the compound, studied by spectrophotometric methods shows that the molar ratio BZF:Pd(II):eosin is 1:1:1. Optimal conditions for the reaction were established and the procedure was validated. The calibration graph was linear over the range 0.06-0.3 mg mL 21 , with relative standard deviation (RSD) 0.3%. The proposed method was successfully applied for the determination of bezafibrate in its pharmaceutical product with mean percentage recoveries of 99.74%.

Application of a xanthene dye, eosin Y, as spectroscopic probe in chemical and pharmaceutical analysis; a review

“…Perindopril (Abdellatef, Ayad & Taha, 1999;Rahman & Rahman, 2011), ramipril (Abdellatef, Ayad & Taha, 1999;Ayad et al, 2002), enalapril (Ayad et al 2002) and carbinoxamine (Ramadan and Mandil 2006) were complexed with eosin and zinc (for perindopril) or copper (for all drugs) followed by extraction of the complex with chloroform and measurement of the absorbance of the organic layer at 510-538 nm. Another way to overcome the low solubility of the complex was achieved through the addition of nonionic surfactants, such as methyl cellulose (Fujita et al, 1987;el Walily, Belal & Bakry, 1996;Ayad et al, 2003;El-Enany, 2004;Krebs, Starczewska & Leszczyńska, 2006;Abdellatef, 2007;El-Didamony, 2007;Omar, 2010;Al-Tamimi, 2013) or polyvinyl alcohol (Mori et al 1986). The addition of surfactants increased the complex stability and prevented its precipitation.…”

Application of Carbon Paste Electrode Modified with Carbon Nanofibres/Polyaniline/Platinum Nanoparticles as an Electrochemical Sensor for the Determination of Bezafibrate

“…A wide variety of analytical methods for the quantitative determination of BZF are reported in the literature. Some of these methods include high performance liquid chromatography (HPLC) , gas chromatography (GC) , HPLC‐UV , on line solid phase extraction liquid chromatography coupled to switching polarity electrospray ionization tandem mass spectroscopy (LC‐ESI/MS) and spectrophotometry . However, most of these methods have complicated procedures hence, they require more proficient operators.…”