Spectrophotometric Determination of Etilefrine HCl, Salbutamol Sulphate and Tiemonium Methyl Sulphate Using Surface Plasmon Resonance Band of Gold Nanoparticles

Abstract

A simple and sensitive method was developed for spectrophotometric determination of etilefrine hydrochloride, salbutamol sulphate and tiemonium methyl sulphate in pure form and in their pharmaceutical formulations. The method was based on reduction of gold solution to gold nanoparticles by the studied drugs in presence of sodium dodecyl sulphate as stabilising agent. Gold nanoparticles (Au NPs) showed a new absorption band at 530 nm that was used for quantitative determination of the cited drugs. Different variables were examined and optimised in the experiment as gold solution concentration, type of buffer, suitable pH, stabilising agent, order of addition, time and temperature of the reaction. Under optimum conditions, the calibration curves were linear with concentration ranges of 3.0-20.0, 5.0-18.0 and 2.0-26.0 μg/mL for etilefrine Hydrochloride, salbutamol sulphate and tiemonium methyl sulphate respectively. The method was applied successfully to determine the studied drugs in pure form and in their pharmaceutical dosage forms, exhibiting good reproducibility and accuracy.

Application of Cloud Point Method for Spectrophotometric Determination of Salbutamol Sulphate and Methyldopa

“…The present spectrophotometric method has been compared with other spectrophotometric methods for determination of salbutamol and methyldopa. These methods are depended on the reduction of gold to gold nanoparticles in the presence of SDS surfactant for determination of salbutamol [29], 2,6-dichloroquinone-4-chlorimide (DCQ) in the medium of acetate buffer as coupling reagent for determination of methyldopa [30], and application of cloud point extraction in oxidative coupling reaction for determination of methyldopa and salbutamol using thiosemicarbazide and 4-nitrophenyl hydrazine respectively [15]. As seen in Table 4, the suggested method is more sensitive, accurate and precise than other methods.…”

Green Prospective Approach of Chromium Zinc Oxide Nanoparticles for Highly Ultrasensitive Electrochemical Detection of Anti-hypotensive Medication in Various Matrices

“…Many analytical approaches for quantifying ETF in different matrices were presented. The majority of these investigations are focused on determining ETF by spectrophotometric, chemiluminescence assay, HPLC, LC-MS, and GC. − Despite their great accuracy and sensitivity, these techniques require expensive laboratory-based instruments, skilled technicians, tedious transportation, and storage protocols. Moreover, sample preparation procedures are usually time-consuming, labor-intensive, and require various regular analysis processes.…”

Determination of Salbutamol Sulfate in pharmaceutical formulation with differential pulse voltammetry using poly(Benzofuran-2-Boronic acid) modified platinum electrode

“…For these potential side effects, detection of the SBS in body fluids and urine is very important. Spectrophotometric techniques [4][5][6][7][8], gas chromatography-mass spectrometry [9,10], high performance liquid chromatography [11,12], liquid chromatography-mass spectrometry [13][14][15], capillary electrophoresis [16][17][18][19][20] and chemiluminescence [21,22] are used for the determination of salbutamol in different samples. These techniques need costly equipment, competent personnel and require complex sample pretreatment procedure.…”