Spirulina supplementation improves bone structural strength and stiffness in streptozocin-induced diabetic rats

Ekeuku, Sophia Ogechi; Chong, Pei Nee; Chan, Hor Kuan; Mohamed, Norazlina; Froemming, Gabriele Ruth Anisah; Okechukwu, Patrick Nwabueze

doi:10.1016/j.jtcme.2021.07.010

Cited by 12 publications

(12 citation statements)

References 50 publications

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“…In addition, hepatoprotective properties, protection of β cells against free radical damage, and the ability to increase vitamin D in the blood are correlated with these microalgae. These characteristics can improve bone formation, as evidenced in the study by Ekeuku et al (2021) , by increasing osteocalcin expression and the number of osteocytes/osteoblasts. Thus, its use associated with the drug metformin stimulates osteoblast proliferation and prevents osteocytosis apoptosis.…”

Section: Biological Effects Of Spirulina Spp Bioac...mentioning

confidence: 81%

“…Thus, increasing the number of osteocytes and osteoblasts and protecting bones. Ekeuku et al (2021) Wound healing potential Spirulina platensis NI The topical supplementation with Spirulina demonstrated marked epithelization and complete connective tissue remodeling. These processes occur by improving the wound healing process by increasing angiogenesis and collagen deposition.…”

Section: Biological Effects Of Spirulina Spp Bioac...mentioning

confidence: 99%

“…is considered a superfood trend, which has been highlighted for its potential as a beneficial adjuvant therapy, especially in the treatment of diabetes and osteoporosis. The hypoglycemic property of S. platensis is associated with the presence of chromium, which, when binding to peptides that bind to insulin receptors, increases the activity of lowering plasma glucose levels ( Ekeuku et al, 2021 ). In addition, hepatoprotective properties, protection of β cells against free radical damage, and the ability to increase vitamin D in the blood are correlated with these microalgae.…”

Section: Biological Effects Of Spirulina Spp Bioac...mentioning

confidence: 99%

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Functional properties of bioactive compounds from Spirulina spp.: Current status and future trends

Bortolini

Maciel

Fernandes

et al. 2022

Food Chemistry: Molecular Sciences

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Section: Biological Effects Of Spirulina Spp Bioac...mentioning

confidence: 81%

Section: Biological Effects Of Spirulina Spp Bioac...mentioning

confidence: 99%

Section: Biological Effects Of Spirulina Spp Bioac...mentioning

confidence: 99%

See 1 more Smart Citation

Functional properties of bioactive compounds from Spirulina spp.: Current status and future trends

Bortolini

Maciel

Fernandes

et al. 2022

Food Chemistry: Molecular Sciences

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“…So far, Arthrospira sp. (Spirulina) has been made accessible for human intake as a nutritional supplementto combat the deficiency of Vitamin B 12 especially, thereby improving bone strength and stiffness as well as inhibiting the formation of ulcers [60,61]. In addition, numerous studies have showed the medicinal important of Spirulina as a rich source vitamin E and β-carotene.…”

Section: Vitaminsmentioning

confidence: 99%

Versatile Applications of Cyanobacteria in Biotechnology

et al. 2022

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Cyanobacteria are blue-green Gram-negative and photosynthetic bacteria which are seen as one of the most morphologically numerous groups of prokaryotes. Because of their ability to fix gaseous nitrogen and carbon dioxide to organic materials, they are known to play important roles in the universal nutrient cycle. Cyanobacteria has emerged as one of the promising resources to combat the issues of global warming, disease outbreaks, nutrition insecurity, energy crises as well as persistent daily human population increases. Cyanobacteria possess significant levels of macro and micronutrient substances which facilitate the versatile popularity to be utilized as human food and protein supplements in many countries such as Asia. Cyanobacteria has been employed as a complementary dietary constituent of feed for poultry and as vitamin and protein supplement in aquatic lives. They are effectively used to deal with numerous tasks in various fields of biotechnology, such as agricultural (including aquaculture), industrial (food and dairy products), environmental (pollution control), biofuel (bioenergy) and pharmaceutical biotechnology (such as antimicrobial, anti-inflammatory, immunosuppressant, anticoagulant and antitumor); recently, the growing interest of applying them as biocatalysts has been observed as well. Cyanobacteria are known to generate a numerous variety of bioactive compounds. However, the versatile potential applications of cyanobacteria in biotechnology could be their significant growth rate and survival in severe environmental conditions due to their distinct and unique metabolic pathways as well as active defensive mechanisms. In this review, we elaborated on the versatile cyanobacteria applications in different areas of biotechnology. We also emphasized the factors that could impede the implementation to cyanobacteria applications in biotechnology and the execution of strategies to enhance their effective applications.

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“…has been made available for consumption by humans as a supplementary diet. Indeed, several in vivo studies have showed the health benefits of well-characterized Spirulina, a rich source of vitamin B12, β-carotene and vitamin E. For example, Spirulina can improve bone strength and stiffness due to vitamin B12 deficiency [232], prevent ulcer formation [233] and recover blood retinol status [234].…”

Section: Vitaminsmentioning

confidence: 99%

Bioactive Metabolites Produced by Cyanobacteria for Growth Adaptation and Their Pharmacological Properties

Nandagopal

Steven

Chan

et al. 2021

Biology

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Cyanobacteria are the most abundant oxygenic photosynthetic organisms inhabiting various ecosystems on earth. As with all other photosynthetic organisms, cyanobacteria release oxygen as a byproduct during photosynthesis. In fact, some cyanobacterial species are involved in the global nitrogen cycles by fixing atmospheric nitrogen. Environmental factors influence the dynamic, physiological characteristics, and metabolic profiles of cyanobacteria, which results in their great adaptation ability to survive in diverse ecosystems. The evolution of these primitive bacteria resulted from the unique settings of photosynthetic machineries and the production of bioactive compounds. Specifically, bioactive compounds play roles as regulators to provide protection against extrinsic factors and act as intracellular signaling molecules to promote colonization. In addition to the roles of bioactive metabolites as indole alkaloids, terpenoids, mycosporine-like amino acids, non-ribosomal peptides, polyketides, ribosomal peptides, phenolic acid, flavonoids, vitamins, and antimetabolites for cyanobacterial survival in numerous habitats, which is the focus of this review, the bioactivities of these compounds for the treatment of various diseases are also discussed.

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Spirulina supplementation improves bone structural strength and stiffness in streptozocin-induced diabetic rats

Cited by 12 publications

References 50 publications

Functional properties of bioactive compounds from Spirulina spp.: Current status and future trends

Functional properties of bioactive compounds from Spirulina spp.: Current status and future trends

Versatile Applications of Cyanobacteria in Biotechnology

Bioactive Metabolites Produced by Cyanobacteria for Growth Adaptation and Their Pharmacological Properties

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