1996
DOI: 10.1093/ajhp/53.3.294
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Stability and compatibility of granisetron hydrochloride in i.v. solutions and oral liquids and during simulated Y-site injection with selected drugs

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Cited by 11 publications
(9 citation statements)
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“…According to the United States Pharmacopeia chapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-use period of 48 hours for non-refrigerated samples 19. Second, the investigated duration in other reports was much longer than the 48 hours used in our study 12 17. However, infusions are always used immediately after preparation, so our research may provide valuable evidence on compatibility of DSP with 5-HT3RAs in infusion solutions.…”
Section: Discussionmentioning
confidence: 83%
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“…According to the United States Pharmacopeia chapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-use period of 48 hours for non-refrigerated samples 19. Second, the investigated duration in other reports was much longer than the 48 hours used in our study 12 17. However, infusions are always used immediately after preparation, so our research may provide valuable evidence on compatibility of DSP with 5-HT3RAs in infusion solutions.…”
Section: Discussionmentioning
confidence: 83%
“…Several relevant studies were available with varied evaluation and study methods 8–10 12–18. As the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,9 12 13 we did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-HT3RAs in infusion solutions 10 12–18.…”
Section: Discussionmentioning
confidence: 99%
“…[2225] Regarding granisetron hydrochloride, previous studies have demonstrated that incompatibility occurred in solution when combined with aciclovir sodium, amphotericin B, amsacrine, lansoprazole, or with sodium bicarbonate. [26,27] For tropisetron hydrochloride, Sun et al have revealed the instability of the drug mixtures containing tropisetron hydrochloride with fosaprepitant, which seemed to precipitate because of pH modification. [28] Similar to the 3 5-HT 3 receptor antagonists, droperidol was demonstrated to be incompatible when combined with allopurinol sodium, amphotericin B cholesteryl sulfate complex, fluorouracil, furosemide, lansoprazole, methotrexate sodium, and pemetrexed disodium.…”
Section: Discussionmentioning
confidence: 99%
“…Precipitation previously had been observed in solutions of ondansetron with a pH greater than 5.7 and, therefore, finding incompatibilities between ondansetron and drugs such as 5-fluorouracil, acyclovir sodium, ganciclovir sodium, alkaline antibiotics, aminophylline, and furosemide, which have alkaline pH values, and amphotericin B and methylprednisolone sodium succinate, which are sensitive to differences in pH, was not surprising. Precipitation of ondansetron in a sodium bicarbonate solution (pH = 8.6) used to alkalinize urine also has been reported (Jarosinski & Hirschfeld, Author Trissel et al, 1991Trissel et al, 1991Trissel et al, 1991Trissel et al, 1991Trissel et al, 1991Trissel et al, 1996Trissel et al, 1991Trissel et al, 1991Trissel et al, 1991Trissel et al, 1991Trissel et al, 1991Trissel et al, 1991Trissel et al, 1997aTrissel et al, 1991Trissel et al, 1991Trissel, 1998Trissel et al, 1991 Granisetron Concentration 50 mcg/ml a 50 mcg/ml a 0.5 mg/ml 50 mcg/ml a 0.5 mg/ml 0.5 mg/ml 0.05 mg/ml b 0.5 mg/ml 50 mcg/ml a 0.5 mg/ml 0.5 mg/ml 50 mcg/ml a 50 mcg/ml a 0.5 mg/ml 0.05 mg/ml a 50 mcg/ml a 0.5 mg/ml 50 mcg/ml a 50 mcg/ml a 50 mcg/ml a 50 mcg/ml a Trissel et al, 1997bTrissel et al, 1997bMayron & Gennaro, 1996…”
Section: Ondansetronmentioning
confidence: 99%
“…Granisetron 0.05 mg/ml also was stable when mixed with dexamethasone sodium phosphate or methylprednisolone hemisuccinate in PVC bags containing 5% dextrose or 0.9% sodium chloride and stored for three days at 20°C. Mayron and Gennaro (1996) found that granisetron 1 mg (as a hydrochloride salt) was stable for 24 hours at room temperature (20°C) in standard IV fluids, including 5% dextrose injection, 5% dextrose plus 0.9% sodium chloride injection, Compatible c Compatible c Compatible c Compatible c Incompatible c Compatible c Compatible c N/A Compatible c Compatible c Compatible c Compatible c Incompatible a Incompatible a Granisetron Compatible b Compatible b Compatible b Compatible b Compatible b Compatible b Compatible b Compatible b Compatible e Compatible e Compatible b Compatible b Compatible b Compatible b Compatible b Compatible b Compatible b Compatible e Compatible b Compatible b Compatible b Compatible b Compatible b Compatible b Compatible b Compatible b Compatible b Compatible b Compatible b N/A Compatible b Compatible e Compatible b Compatible b Compatible b Compatible b Compatible e Compatible b Compatible b Compatible b Compatible b Compatible Incompatible a Compatible a Incompatible a Incompatible a Incompatible a Compatible a Compatible a Incompatible Trissel et al, 1991;b Trissel et al, 1997b;c Data on file with manufacturer; d Trissel, 1998; e Mayron & Gennaro, 1996;f Ceftazidime;g Trissel, Gilbert, & Williams, 1999; N/A-no published information available 5% dextrose plus 0.45% sodium chloride injection, and 0.9% sodium chloride injection stored in PVC bags. Also, 1 ml of granisetron injection and dexamethasone sodium phosphate injection (0.5 ml) were stable and compatible when combined in 50 ml of 0.9% sodium chloride injection in a PVC bag and sto...…”
Section: Granisetronmentioning
confidence: 99%