“…Precipitation previously had been observed in solutions of ondansetron with a pH greater than 5.7 and, therefore, finding incompatibilities between ondansetron and drugs such as 5-fluorouracil, acyclovir sodium, ganciclovir sodium, alkaline antibiotics, aminophylline, and furosemide, which have alkaline pH values, and amphotericin B and methylprednisolone sodium succinate, which are sensitive to differences in pH, was not surprising. Precipitation of ondansetron in a sodium bicarbonate solution (pH = 8.6) used to alkalinize urine also has been reported (Jarosinski & Hirschfeld, Author Trissel et al, 1991Trissel et al, 1991Trissel et al, 1991Trissel et al, 1991Trissel et al, 1991Trissel et al, 1996Trissel et al, 1991Trissel et al, 1991Trissel et al, 1991Trissel et al, 1991Trissel et al, 1991Trissel et al, 1991Trissel et al, 1997aTrissel et al, 1991Trissel et al, 1991Trissel, 1998Trissel et al, 1991 Granisetron Concentration 50 mcg/ml a 50 mcg/ml a 0.5 mg/ml 50 mcg/ml a 0.5 mg/ml 0.5 mg/ml 0.05 mg/ml b 0.5 mg/ml 50 mcg/ml a 0.5 mg/ml 0.5 mg/ml 50 mcg/ml a 50 mcg/ml a 0.5 mg/ml 0.05 mg/ml a 50 mcg/ml a 0.5 mg/ml 50 mcg/ml a 50 mcg/ml a 50 mcg/ml a 50 mcg/ml a Trissel et al, 1997bTrissel et al, 1997bMayron & Gennaro, 1996…”