Stem Cells Derived from Tooth Periodontal Ligament Enhance Functional Angiogenesis by Endothelial Cells

Yeasmin, Shamima; Ceccarelli, Jacob; Vigen, Marina; Carrion, Bita; Putnam, Andrew J.; Tarlé, Susan A.; Kaigler, Darnell

doi:10.1089/ten.tea.2013.0512

Cited by 38 publications

(44 citation statements)

References 33 publications

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“…Further, PDLSC have been shown to be a viable, alternative source to autologous Schwann cells, in one instance promoting the regeneration of the mental nerve [31] . Lastly, like other MSC, PDLSC also show paracrine induction of angiogenesis in vitro and in vivo [32] . Thus, in addition to their multilineage potential, the possibility of an immortal cell line has made PDLSC highly promising for tissue engineering applications [5] .…”

Section: Background and Applicationsmentioning

confidence: 86%

Craniomaxillofacial Sources of Mesenchymal Stem Cells: A Brief Review

Nguyen

James

et al. 2015

International Journal of Orthopaedics

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Tissue specific mesenchymal stem cells are of great scientific interest across diverse fields in stem cell biology and medicine. Sources of mesenchymal stem cells (MSC) in the craniomaxillofacial skeleton are numerous and are of significant interest to craniofacial and oral surgeons, among other medical and dental specialties. Mesenchymal stem cells are defined by their characteristic cell surface marker expression, multipotentiality and ability for self-renewal. Bone marrow derived MSC (BMSC) are most commonly studied, but are of low abundance in the craniomaxillofacial (CMF) skeleton. Alternative CMF sources of MSC are diverse and include dental pulpal stem cells (DPSC), periodontal ligament stem cells (PDLSC), suture-derived mesenchymal stromal cells (SMC), gingival mesenchymal stem cells (GMSC)and adipose-derived MSC (ASC). This brief review will introduce various MSC sources derived from the head and neck, along with a discussion of their identity, characteristics and results of preclinical studies in tissue engineering.

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Section: Background and Applicationsmentioning

confidence: 86%

Craniomaxillofacial Sources of Mesenchymal Stem Cells: A Brief Review

Nguyen

James

et al. 2015

International Journal of Orthopaedics

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“…The paracrine function of MSCs has been widely studied . It is believed that MSCs can promote angiogenesis by secreting cytokines .…”

Section: Discussionmentioning

confidence: 99%

“…It is believed that MSCs can promote angiogenesis by secreting cytokines . PDLSCs have been proved to have vascularization potential as the MSCs in periodontal ligament both in vivo and in vitro . Periodontitis is a chronic inflammatory disease featured by aberrant vascularization.…”

Section: Discussionmentioning

confidence: 99%

Activation of autophagy in periodontal ligament mesenchymal stem cells promotes angiogenesis in periodontitis

Wei

et al. 2018

Journal of Periodontology

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“…SHED constitutively expressed vascular endothelial growth factor (VEGF) receptor (VEGFR)-1 and its co-receptor neuropilin-1, and moreover, could differentiate into endothelial cells via exogenous VEGF addition, as identified by the up-regulation of endothelium-related marker expression and the formation of capillary-like sprouts [43]. Surprisingly, a recent study demonstrated that SHED also secreted soluble proangiogenic factors that promoted the formation of capillary-like sprouts in endothelial cells [44]. These results suggested that SHED possessed the potential not only to differentiate into endothelial cells but also to induce the differentiation of endothelial cells that were located around them.…”

Section: Exfoliated Deciduous Teethmentioning

confidence: 99%