Steroid Compounds From Gynura pseudochina (Lour) DC

Abstract

Daun dewa (Gynura pseudochina Lour DC) is a one of popular traditional medicine to treat various diseases. This research was conducted to isolate chemical compounds from daun dewa leaves using various chromatographic techniques. A steroid mixture namely -sitosterol (1a) and stigmasterol (1b) were isolated for the first time from the methanol extract of daun dewa. The structures were determined base on spectral evidence including IR, NMR 1D and NMR 2D.Keywords: Gynura pseudochina, -sitosterol, stigmasterol. ABSTRAKDaun dewa (Gynura pseudochina Lour DC) merupakan salah satu tumbuhan tradisional yang dimanfaatkan untuk mengobati berbagai penyakit. Penelitian ini bertujuan untuk mengisolasi senyawa kimia dari daun tumbuhan daun dewa. Suatu campuran steroid yaitu -sitosterol (1a) dan stigmasterol (1b) telah diisolasi untuk pertama kalinya dari ekstrak metanol Gynura pseudochina (Lour) DC. Struktur kedua senyawa ditetapkan berdasarkan data-data spektroskopi yaitu IR, NMR 1D dan 2D.

Ethnomedicinal uses, phytochemistry, and biological activities of plants of the genus Gynura

“…Whole plant (Qi et al, 2009) 10 Gynuramine G. scandens Whole plant (Wiedenfeld, 1982) 11 Acetylgynuramine G. scandens Whole plant (Wiedenfeld, 1982) 12 Senecionine N-oxide G. japonica Roots (Fang et al, 2014) 47 G. segetum Whole plant, roots, tuber. (Qi et al, 2009;Yang et al, 2009) Retrorsine N-oxide G. bicolor Aerial parts (Chen et (Chao et al, 2015;Chen et al, 2015) G. divaricata Aerial parts (Chen et al, 2015) 49 Leaves, stems (Hu et al, 2019;Sadikun et al, 1996) G. pseudochina Whole plant, Leaves (Ferlinahayati et al, 2017;Gultom, 2016) 55…”

Antioxidant and Anti-Inflammatory Effects of Genus Gynura: A Systematic Review

“… 3,5-Di-O-caffeoylquinic acid (Isochlorogenic acid A) (PubChem CID: 6474310) Lu et al (2012) , Wu et al (2015) , Qiu X. L. et al (2018) 3-O-Feruloylquinic acid (PubChem CID: 9799386) 3-O- p -Coumaroylquinic acid (PubChem CID: 9945785) 4,5-Di-O-Caffeoylquinic acid (Isochlorogenic acid C) (PubChem CID: 6474309) 5-O-Caffeoylquinic acid (Neochlorogenic Acid) (PubChem CID: 5280633) 5-O- p -Coumaroylquinic acid (PubChem CID: 9945785) Anthocyanin (PubChem CID: 145858) Caffeoyl glucose (PubChem CID: 129715972) Citric acid (PubChem CID: 311) Dihydro-phellopterin (PubChem CID: not found) Gallic acid (PubChem CID: 370) Geniposide (PubChem CID: 107848) Guanosine (PubChem CID: 135398635) Isobavachalcone (PubChem CID: 5281255) Kaempferol-3-O-caffeoylate (PubChem CID: not found) Kaempferol-3-O-glucoside (Astragalin) (PubChem CID: 5282102) Malic acid (PubChem CID: 525) Phenylalanine (PubChem CID: 6140) Protocatechuate-O-glucoside (PubChem CID: not found) Quercetin (PubChem CID: 5280343) Quercetin-3-acetylhexose (PubChem CID: not found) Quercetin-3-O-galactoside (PubChem CID: 5281643) Quercetin-3-O-rutinoside (Rutin) (PubChem CID: 5280805) Tryptophan (PubChem CID: 6305) Uridine (PubChem CID: 6029) β-Carotene (PubChem CID: 5280489) Gynura pseudochina (L.) DC. (+)-Tephropurpurin (PubChem CID: 10047971) Siriwatanametanon and Heinrich (2011) , ...…”