Steroid-sparing effect of wormwood (Artemisia absinthium) in Crohn's disease: A double-blind placebo-controlled study

Omer, Bilal; Krebs, Simone; Omer, Hayder A; Noor, Tahmina

doi:10.1016/j.phymed.2007.01.001

Cited by 95 publications

(50 citation statements)

References 6 publications

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“…These results were in agreement with previous studies that showed that SLAK exerted an anti-inflammatory effect in J774A.1 macrophages through the inhibition of NO and PGE 2 production as well iNOS and COX-2 expression (Emami et al, 2010). Moreover, the overall impact of these changes also reflect results of previous studies that demonstrated that various individual sesquiterpene compounds from Artemisia exert anti-inflammatory effects that may be effective in treating some types of experimental inflammation/autoimmune conditions (Choi et al, 2011;Ho et al, 2014;Kim et al, 2002;Lu et al, 2009;Omer et al, 2007;Sun et al, 2010;Yang et al, 2012).…”

Section: Discussionsupporting

confidence: 92%

In vitroimmunomodulatory properties of a sesquiterpene lactone-bearing fraction fromArtemisia khorassanica

Rabe¹,

Iranshahi

Rastin³

et al. 2014

Journal of Immunotoxicology

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Artemisia species are important medicinal plants throughout the world. The present in vitro study, using a sesquiterpene lactone-bearing fraction prepared from Artemisia khorassanica (SLAK), sought to investigate immunomodulatory/anti-inflammatory properties of this plant and elucidate potential underlying mechanisms for the actions. Effects of the SLAK on mitogeninduced murine splenocyte proliferation and interleukin (IL)-4 and interferon (IFN)-secretion were evaluated. To assess anti-inflammatory activities, levels of inducible of nitric oxide (NO) and prostaglandin E 2 (PGE 2 ), as well as expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in peritoneal macrophages was examined. The results showed that SLAK noticeably was capable of suppressing PHA/LPS-stimulated splenocyte proliferation and of up-regulating production of the T-helper (T H )-2 cell cytokine IL-4 while down-regulating formation of T H 1 IFN. In addition, while SLAK caused negligible proliferation inhibition, peritoneal macrophages displayed considerable decrease in NO and PGE 2 production along with iNOS and COX-2 expression. The current experiment shows Artemisia khorasanica -a traditionally used herb -may have immunomodulatory and anti-inflammatory effects. It is anticipated that the ingredients may be employed as therapeutic candidates in the regulation of some immune responses implicated in various conditions and ailments.

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Section: Discussionsupporting

confidence: 92%

In vitroimmunomodulatory properties of a sesquiterpene lactone-bearing fraction fromArtemisia khorassanica

Rabe¹,

Iranshahi

Rastin³

et al. 2014

Journal of Immunotoxicology

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“…Phytochemically, A. absinthium has been reported to possess essential oil, absinthin, anabsin, anabsinthin, artabsin, and matricin; resins, lactones, and organic acids (Omer et al, 2007). Wormwood also contains flavonoids such as quercetin, rutin (Rice-Evans et al, 1996;Lee et al, 2004), and other flavonoid glycosides (isoquercitrin, quercitin-3-O-β-d-glucoside, quercitin-3-O-rhamnoglucoside, isorhamnetin-3-O-rhamnoglucoside, isorhamnetin-3-glucoside), and phenolic acids such as chlorogenic, syringic, coumaric, salicylic, and vanillic acids (Kordali et al, 2005) are probably involved in the mechanism of free-radical scavenging activity.…”

Section: Research Articlementioning

confidence: 99%

Evaluation of antioxidant and free-radical scavenging potential ofArtemisia absinthium

Bora¹,

Sharma²

2011

Pharmaceutical Biology

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“…These compounds have shown repellent and insecticidal effect to Spodoptera littoralis Boisduval (Lepidoptera: Noctuidae) (Viegas Júnior, 2003). Another plant of the same genus, A. absinthium, showed 100% mortality of C. cannis, when the latter was exposed, for 10 minutes, to the infusion of the leaves of that plant (Leite et al, 2006), which is rich in essential oil containing terpenes and absinthin (Omer et al, 2007).…”

Section: Resultsmentioning

confidence: 99%

Medicinal plant extracts on the control of Diabrotica speciosa (Coleoptera: Chrysomelidae)

Barbosa

Leite

Martins

et al. 2013

Rev. bras. plantas med.

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RESUMO: Extratos de plantas medicinais no controle de Diabrotica speciosa (Coleoptera: Chrysomelidae). O objetivo deste trabalho foi avaliar o efeito inseticida de extratos aquosos, alcoólicos e oleosos de folhas de oito plantas medicinais contra Diabrotica speciosa preparadas em cinco concentrações. Os extratos que utilizaram óleo de soja comercial como solvente apresentaram as maiores mortalidades de D. speciosa em função do próprio óleo, independentemente das plantas utilizadas em suas concentrações. Sendo assim, o óleo de soja comercial foi descartado como solvente, pois nestes volumes acarretaria sérios problemas de fitotoxidade. Após 24 horas de exposição da praga aos extratos, os maiores valores de mortalidade de D. speciosa foram observados nos extratos de Copaifera Langsdorfii e de Chenopodium ambrosioides, ambos em álcool 5%, e de Artemisia verlotorum, em água 10%. Entretanto, na última avaliação de mortalidade (48 h), o extrato de C. langsdorfii em álcool a 5% apresentou maior mortalidade dessa praga, seguida pelo extrato alcoólico a 5% de C. ambrosioides comparada às demais plantas. Palavras-chave: Ruta graveolens, Artemisia verlotorum, Stryphnodendron adstringens, Baccharis trimera, Copaifera langsdorffii ABSTRACT:The aim of this study was to evaluate the insecticidal effect of aqueous, alcoholic, and oil extracts from leaves of eight medicinal plants against Diabrotica speciosa prepared at five concentrations. The extracts that used commercial soybean oil as solvent showed the highest D. speciosa mortality due to the solvent itself, regardless of the used plants and their concentrations. Thus, commercial soybean oil was discarded as solvent since at these volumes it would cause serious phytotoxicity problems. After 24 hours of exposure of the pest to the extracts, the highest D. speciosa mortality values were observed for Copaifera langsdorfii and Chenopodium ambrosioides extracts, both in 5% alcohol, and Artemisia verlotorum, in 10% water. However, in the last mortality assessment (48 h), C. langsdorfii extract in 5% alcohol showed higher mortality of this pest, followed by C. ambrosioides extract in 5% alcohol, compared to the remaining plants.

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Steroid-sparing effect of wormwood (Artemisia absinthium) in Crohn's disease: A double-blind placebo-controlled study

Cited by 95 publications

References 6 publications

In vitroimmunomodulatory properties of a sesquiterpene lactone-bearing fraction fromArtemisia khorassanica

In vitroimmunomodulatory properties of a sesquiterpene lactone-bearing fraction fromArtemisia khorassanica

Evaluation of antioxidant and free-radical scavenging potential ofArtemisia absinthium

Medicinal plant extracts on the control of Diabrotica speciosa (Coleoptera: Chrysomelidae)

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