Stress-Induced Changes in the Liver of Rats with Different Resistance to Stress

Abstract

We compared changes in the liver structure in stress-resistant and stress-sensitive rats under conditions of chronic stress exposure. The number of degenerative cells, specific area of degenerative part of hepatocyte cytoplasm, and specific area of intralobular sinusoidal capillaries increased in animals of both groups. These parameters were significantly higher in stresss-ensitive rats. Reparative processes that manifested in increased in number of binucleated hepatocytes and number of nucleoli in nuclei were observed in the liver parenchyma. These changes were more pronounced in animals with high resistance to stress. Nucleus hypertrophy was also found in these rats.

Somatostatin analogue, Octreotide, improves restraint stress-induced liver injury by ameliorating oxidative stress, inflammatory response, and activation of hepatic stellate cells

“…Furthermore, morphometrically, results approved that IS adversely affects the hepatic morphology. This result was consistent with other studies carried out by Solin and Lyashev (2014). In addition, the density of 2017) and Ohta et al (2007).…”

Adaptogenic potential of royal jelly in liver of rats exposed to chronic stress

“…In the present study, restraint and cold stress not only augmented corticosterone levels, blood glucose levels and biomarkers of oxidative stress, but also diminished the glutathione antioxidant defense system in the liver tissues. Our results corroborate other studies that reported an increase of corticosterone levels under several stress models such as restraint and cold, immobilization and cold, besides other models of stress induction [ 2 , 4 – 6 , 20 , 29 ]. Besides that, we showed a decreased of the corticosterone level associated with RJ supplementation, even in absence of stress.…”

“…Physical and psychological stress activates the hypothalamic-pituitary-adrenal (HPA) axis and the autonomic nervous system (ANS), increasing plasma glucocorticoid levels [ 3 ]. Increased corticosterone levels were observed in stress responses using the stress models, such as restraint and cold [ 2 ], immobilization [ 4 ], cold [ 5 ], cold water immersion [ 5 ], electric foot shock [ 6 ] and social isolation stress [ 7 ]. Corticosterone increases gluconeogenesis and hepatic glycogenolysis in rats, resulting in an increase in the availability of metabolic substrates [ 8 ].…”

Impact of Immobilization Stress on Erythropoiesis, Alterations in the Antioxidant System, and Potential Correction with Stevia rebaudiana Bertoni in Rabbit

“…As a stress factor, it causes tension in regulatory mechanisms, disruption of vegetative functions reduces the reserve capacity of the body, and inhibits energy processes [3,4]. Short-term exposure to immobilization stress causes erythropenia, a decrease in hemoglobin content and osmotic stability of erythrocytes, and an increase in the number of destroyed erythrocytes in the spleen [5][6][7] against the background of changes in various organs and systems of the body. When exposed to stress factors, the body quickly mobilizes its adaptive, compensatory, and protective mechanisms to counteract the violation of physiological balance, however, prolonged exposure causes anatomical and functional disorders of organ systems, and causes the development of pathological processes [8].…”