Stress-Induced Immunomodulation: What Is It, If It Is?

Golub, Mari S.; Gershwin, M. Eric

doi:10.1007/978-1-4614-7544-6_11

Cited by 9 publications

(4 citation statements)

References 32 publications

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“…Otherwise the vitamin E supply together with the feeding of a T-2 toxin contaminated diet has additional but not significantly positive effect on the haemagglutination inhibition titre, namely antibody formation against Newcastle disease virus protein. That positive tendency was possibly caused by the inhibitory effect of vitamin E on stress-induced glucocorticoid response (Golub and Gershwin 1985), which eliminated the immune depressive effect of : Different superscripts in the same raw mean significant difference at P  0.05 as compared to the control and the T-2 toxin challenged groups, respectively : Different superscripts in the same raw mean significant difference at P  0.05 as compared to the control and the T-2 toxin challenged groups, respectively glucocorticoids as a physiological response to the T-2 toxin load as environmental stressor during the first week; however, that effect decreased during the second week, possibly due to the lower utilisation of vitamin E in T-2 toxin challenged birds.…”

Section: Resultsmentioning

confidence: 98%

Effect of Vitamin E Supplementation on the Haemagglutination Inhibitor Titre Vaccinated against Newcastle Disease in T-2 Toxin Challenged Chickens

Kovács-Weber

Fodor²,

Balogh

et al. 2008

Acta Vet. Brno

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) and/or vitamin E supplementation in drinking water (10.5 mg/animal·day -1 ) for 14 days on the haemagglutination inhibition titres against Newcastle disease virus was investigated in repeatedly vaccinated (on 23 days of age) broiler chicken. The animals were divided into four groups: (1) control; (2) treated with vitamin E; (3) fed a T-2 toxin contaminated feed; (4) fed a T-2 toxin contaminated diet and treated with vitamin E. Blood samples were taken on days 7 and 14 of the experiment for determination of sera titres and vitamin E content, liver samples were also taken on the same days for vitamin E determination. It was found that haemagglutination titres increased in comparison to the controls as an effect of vitamin E supply and also a low dose T-2 toxin challenge. The combination of both treatments showed some synergistic effect. The utilization of vitamin E decreased by the feeding of T-2 toxin contaminated diet, particularly in the liver.

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Section: Resultsmentioning

confidence: 98%

Effect of Vitamin E Supplementation on the Haemagglutination Inhibitor Titre Vaccinated against Newcastle Disease in T-2 Toxin Challenged Chickens

Kovács-Weber

Fodor²,

Balogh

et al. 2008

Acta Vet. Brno

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“…Similar reduction in cortisol levels by vitamin C in heat stressed goats was reported by Kobisey (1997), by vitamin E by Webel et al (1998), and in heat-stressed pigs by both vitamin E and C by Shenglins et al (2003). This reduction in cortisol levels by vitamin E and C is not yet fully understood but may be achieved by reducing the synthesis and/or secretion of cortisol or by breaking it down (Golub and Gershwin, 1985;Orth, 1992;Webel et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Antioxidants Supplementation on Acid Base Balance during Heat Stress in Goats

Sivakumar¹,

Singh²,

Varshney³

2010

Asian Australas. J. Anim. Sci

135

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The effects of vitamin C and vitamin E with selenium on acid-base balance and some stress hormones were evaluated during heat stress in goats. Goats, 1.5 years of age, were divided into control, heat stress and antioxidant treatment groups 1, 2 and 3. Except for the control, all groups were exposed to a temperature of 40±2°C with a relative humidity of 30% for 5 h/d for 21 days in a psychrometric chamber. Rectal temperature and respiratory rates were recorded daily post exposure. Blood samples were collected on every 3rd day for estimation of plasma vitamins C and E, total antioxidant activity and hormones, and separate blood samples were taken to estimate acid-base status. The rectal temperature and respiratory rates were increased (p<0.05) in the heat stress group only. Except for pH and pO 2 , which were increased significantly (p<0.05) other parameters of acid-base balance such as pCO 2 , HCO 3

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“…Glucocorticoids and adrenaline are potential modulators of immune function and have been linked to regulation of immune function attributable either to the presence of receptors on immune effecter cells or the demonstration of altered immune response after exogenous administration (Golub and Gershwin, 1985). The opposing effects of clenbuterol against corticosterone and the adrenergic effect of clenbuterol may have some influence on immunoresponsiveness and the MFO system.…”

Section: Introductionmentioning

confidence: 99%

Effects of a beta‐adrenergic agonist clenbuterol) on performance, carcase composition, hepatic microsomal mixed function oxidase and antibody production in female broilers treated with or without corticosterone

Takahashi

Akiba

Horiguchi

1993

British Poultry Science

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1. Beta-adrenergic agonist (Clenbuterol, 0.33 mg/kg) and corticosterone (10 mg/kg) were incorporated into a diet based on maize and soybean meal. Their effects on performance, carcase composition, hepatic microsomal mixed function oxidase and antibody production were investigated in female broilers. 2. Dietary corticosterone reduced the titre to sheep red blood cells, while it was unchanged by clenbuterol. 3. Clenbuterol exerted a promoting effect on gain-to-food ratio, carcase protein and hepatic microsomal cytochrome P-450 content. 4. Addition of clenbuterol to the corticosterone-containing diet prevented the increase in abdominal fat weight and uric acid excretion induced by corticosterone, but did not affect total fat mass. 5. The results showed that clenbuterol reduced abdominal rather than carcase fat and prevented protein degradation in the body when chicks were treated with corticosterone. Clenbuterol also influenced the content of cytochrome P-450, but not the humoral immunity.

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Stress-Induced Immunomodulation: What Is It, If It Is?

Cited by 9 publications

References 32 publications

Effect of Vitamin E Supplementation on the Haemagglutination Inhibitor Titre Vaccinated against Newcastle Disease in T-2 Toxin Challenged Chickens

Effect of Vitamin E Supplementation on the Haemagglutination Inhibitor Titre Vaccinated against Newcastle Disease in T-2 Toxin Challenged Chickens

Antioxidants Supplementation on Acid Base Balance during Heat Stress in Goats

Effects of a beta‐adrenergic agonist clenbuterol) on performance, carcase composition, hepatic microsomal mixed function oxidase and antibody production in female broilers treated with or without corticosterone

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