Strontium and magnesium ions released from bioactive titanium metal promote early bone bonding in a rabbit implant model

Okuzu, Yaichiro; Fujibayashi, Shunsuke; Yamaguchi, Seiji; Yamamoto, Kōji; Shimizu, Takayoshi; Sono, Takashi; Goto, Koji; Otsuki, Bungo; Matsushita, Tomiharu; Kokubo, Tadashi; Matsuda, Shinya

doi:10.1016/j.actbio.2017.09.019

Cited by 65 publications

(47 citation statements)

References 42 publications

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“…The resultant Ti metal and its alloys slowly release these ions in the body environment so as to promote bone growth or exhibit antibacterial effect. These effects have been confirmed in animal experiments …”

Section: The Search For Novel Bone‐bonding Materials Using Sbfsupporting

confidence: 64%

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Simulated body fluid and the novel bioactive materials derived from it

Kokubo

Yamaguchi

2019

J Biomedical Materials Res

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Professor Larry Hench first reported that certain glasses are able to spontaneously bond to living bone in 1970. This discovery stimulated research into new kinds of bone‐bonding materials. However, there were no guiding principles for this purpose, and many animals were sacrificed in the effort to establish them. The present authors proposed in 1991 that the bone‐bonding capacity of a material could be evaluated by examining apatite formation on its surface in an acellular simulated body fluid (SBF), without the need of performing any animal experiments. Various kinds of novel bone‐bonding bioactive materials based on Ti metal and its alloys with a number of different functions have been developed using SBF. Some of these have entered clinical use as important bone‐repairing materials. Without the method of SBF evaluation, these novel materials would not have been developed. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 968–977, 2019.

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Section: The Search For Novel Bone‐bonding Materials Using Sbfsupporting

confidence: 64%

“…These effects have been confirmed in animal experiments. 60 It is evident from these results that various kinds of novel bioactive materials with different functions can be obtained using SBF.…”

Section: Surface Modification Of Ti Metal For Enhanced Apatite Formationmentioning

confidence: 92%

Simulated body fluid and the novel bioactive materials derived from it

Kokubo

Yamaguchi

2019

J Biomedical Materials Res

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“…As a result, the Ti with the Sr-containing calcium titanate was shown to markedly increase the cell viability after 3 days compared with the untreated Ti. This is consistent with our previous report in which the cell viability in the Ti subjected to the same treatment was significantly increased compared with untreated Ti on 5 days [45]. A similar increase in cell viability was observed in the case of Ti with 0.2% Ag at 1 and 3 days.…”

Section: Discussionsupporting

confidence: 92%

“…When primary mouse bone marrow stromal cells were cultured on the metal surface, increased cell activity including cell attachment, spreading, gene expression, and ALP activity was shown [30]. Yamaguchi et al [29] and Okuzu et al [45] reported that Ti having Sr-containing calcium titanate on its surface increased proliferation and osteogenic differentiation of MC3T3-E1 cells by releasing 0.92 ppm of Sr 2+ ions. In their reports, various types of gene expression, including integrin β1, β catenin, cyclin D1 and ALP were up-regulated and resulted in extracellular mineralization.…”

Section: Discussionmentioning

confidence: 99%

Tri-Functional Calcium-Deficient Calcium Titanate Coating on Titanium Metal by Chemical and Heat Treatment

Yamaguchi

Ito

et al. 2019

Coatings

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The main problem of orthopedic and dental titanium (Ti) implants has been poor bone-bonding to the metal. Various coatings to improve the bone-bonding, including the hydroxyapatite and titania, have been developed, and some of them have been to successfully applied clinical use. On the other hand, there are still challenges to provide antibacterial activity and promotion of bone growth on Ti. It was shown that a calcium-deficient calcium titanate coating on Ti and its alloys exhibits high bone-bonding owing to its apatite formation. In this study, Sr and Ag ions, known for their promotion of bone growth and antibacterial activity, were introduced into the calcium-deficient calcium titanate by a three-step aqueous solution treatment combined with heat. The treated metal formed apatite within 3 days in a simulated body fluid and exhibited antibacterial activity to Escherichia coli without showing any cytotoxicity in MC3T3-E1 preosteoblast cells. Furthermore, the metal slowly released 1.29 ppm of Sr ions. The Ti with calcium-deficient calcium titanate doped with Sr and Ag will be useful for orthopedic and dental implants, since it should bond to bone because of its apatite formation, promote bone growth due to Sr ion release, and prevent infection owing to its antibacterial activity.

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“…As a result, of the excellent mechanical strength, toughness and anti-fatigue performance, metal scaffolds have been widely used in tissue engineering. For example, these metal materials have be used to repair or replace the lesioned or partly worn teeth [32], bones [33], joints or other tissues. These materials can also be regarded as cardiovascular stents [34,35], artificial heart valve [36], etc.…”

Section: Metal Scaffoldsmentioning

confidence: 99%

Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

et al. 2020

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Liposome is one of the most commonly used drug delivery systems in the world, due to its excellent biocompatibility, satisfactory ability in controlling drug release, and passive targeting capability. However, some drawbacks limit the application of liposomes in clinical, such as problems in transporting, storing, and difficulties in maintaining the drug concentration in the local area. Scaffolds usually are used as implants to supply certain mechanical supporting to the defective area or utilized as diagnosis and imaging methods. But, in general, unmodified scaffolds show limited abilities in promoting tissue regeneration and treating diseases. Therefore, liposome-scaffold composite systems are designed to take advantages of both liposomes' biocompatibility and scaffolds' strength to provide a novel system that is more suitable for clinical applications. This review introduces and discusses different types of liposomes and scaffolds, and also the application of liposome-scaffold composite systems in different diseases, such as cancer, diabetes, skin-related diseases, infection and human immunodeficiency virus, and in tissue regeneration like bone, teeth, spinal cord and wound healing.Journal Pre-proof Drug-loaded liposomesLiposomes have been widely investigated as drug carriers, from the approved amphotericin B liposome in 1990 to the successful Onivyde™ in 2015. As drug carriers, liposomes have several advantages, for instance, they can carry various types of drugs, specifically, the internal water core can load hydrophilic drugs and the bilayers can carry hydrophobic ones. Additionally, liposomes exhibit the ability in controlling the drug release and decreasing the side effect of drugs. Furthermore, liposomes also show advantages in low toxicity, non-immunogenic and biodegradability. The phospholipid bilayer can be regarded as satisfactory platforms that can be modified with diverse ligands to achieve the goal of targeting delivery. Furthermore, the stability and efficacy of biological products can also be improved by utilizing liposomes as vehicles. Delivering small molecule hydrophilic drugsSeveral methods, such as reverse evaporation, pH gradient, ammonium sulfate gradient and repeated freeze thawing, are usually applied in the process of preparing small hydrophilic drugs-loaded liposomes. For example, Takeuchi et al. [14] fabricated polyborane encapsulated liposomes though pH gradient or reverse-phase evaporation, then they found that for the encapsulation efficiency of the liposome Journal Pre-proof 6 prepared using the pH gradient was twice as high as that prepared, using reverse-phase evaporation. Additionally, they observed that boron concentration of the polyborane encapsulated liposomes prepared using the pH gradient achieved 110-150 μg/g of tumor tissue. Delivering small molecule hydrophobic drugsUsually the film dispersion method is one of the simplest ways to fabricate lipid drug-loaded liposomes. For example, Fu et al.[15] fabricated novel temperature-sensitive liposomes loading paclitaxel (PTX-...

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Strontium and magnesium ions released from bioactive titanium metal promote early bone bonding in a rabbit implant model

Cited by 65 publications

References 42 publications

Simulated body fluid and the novel bioactive materials derived from it

Simulated body fluid and the novel bioactive materials derived from it

Tri-Functional Calcium-Deficient Calcium Titanate Coating on Titanium Metal by Chemical and Heat Treatment

Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

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