Structural characterization, in vitro and in vivo antioxidant activities of a heteropolysaccharide from the fruiting bodies of Morchella esculenta

Dong

et al. 2022

Int J of Food Sci Tech

Fungal polysaccharides are novel ingredients in functional foods with diverse medicinal properties. Here, a polysaccharide, MSP2‐1, was isolated from Morchella sextelata fruiting bodies and purified using column chromatography. MSP2‐1 (371.5 kDa) is a branched (1 → 4)‐α‐D‐glucan with the O‐6 or O‐3 position occupied by α‐D‐Glcp. Light scattering analysis revealed that MSP2‐1 has a spherical conformation in 0.9% NaCl solution; this was confirmed using transmission electron microscopy. Finally, MPS2‐1 was found to promote proliferation, NO release and cytokine secretion in RAW264.7 cells through a mechanism involving Toll‐like receptor 4. Collectively, these results highlight the potential application of MSP2‐1 as an immunoenhancing compound for hypoimmunity.

Section: Introductionmentioning

confidence: 99%

Structure, conformation and immunomodulatory activity of a polysaccharide from Morchella sextelata

Dong

et al. 2022

Int J of Food Sci Tech

“…Morel contains polysaccharides, proteins, phenolics, and sterol derivatives [ 3 ], with polysaccharides being considered as the most effective substance that endows morel with anti-inflammatory effects [ 4 ] to enhance immunity [ 5 ] and reduce the risk of tumors and cancer [ 6 , 7 ]. Polysaccharides isolated from morel are reported to have backbones of 4)-α-D-Glc p -(1→, →4)-α-D-Glc p -(1 →6)-α-D-Gal p -(1→, →2)-α-D-Gal p -(1→3,6)-α-D-Man p -(1→2,3,6)-α-D-Man p -(1→ [ 5 , 8 , 9 , 10 ]. However, the fine structure of the polysaccharides in M. sextelata has rarely been investigated.…”

Section: Introductionmentioning

confidence: 99%

Structure Identification of Two Polysaccharides from Morchella sextelata with Antioxidant Activity

Jin

et al. 2022

Foods

Mushrooms of the Morchella genus exhibit a variety of biological activities. Two polysaccharides (MSP1-1, 389.0 kDa; MSP1-2, 23.4 kDa) were isolated from Morchella sextelata by subcritical water extraction and column chromatography fractionation. Methylation and nuclear magnetic resonance analysis determined MSP1-1 as a glucan with a backbone of (1→4)-α-D-glucan branched at O-6, and MSP1-2 as a galactomannan with coextracted α-glucan. Light scattering analysis and transmission electron microscopy revealed that MSP1-1 possessed a random coil chain and that MSP1-2 had a network chain. This is the first time that a network structure has been observed in a polysaccharide from M. sextelata. Despite the differences in their chemical structures and conformations, both MSP1-1 and MSP1-2 possessed good thermal stability and showed antioxidant activity. This study provides fundamental data on the structure–activity relationships of M. sextelata polysaccharides.

“…Morels belong to the category of mushrooms, with high nutritional value and delicious taste, both the flavor and the pharmacological effects have been highly regarded ( Tietel and Masaphy, 2018 ). FMP-1 is a heteropolysaccharide in morchella fruiting body, the Mw is 4.7 × 10 3 Da, composed of Man, Glc, and Gal with the molar ratio of 1.00:7.84:1.24, the main chain is 1,4-linked Glcp and 1,6-connected Galp composition ( Cai et al, 2018 ). Previous studies have shown that morel contains many biologically active ingredients, such as polysaccharides, protein, dietary fiber and vitamins.…”

Section: Introductionmentioning

confidence: 99%

Multi-Pharmaceutical Activities of Chinese Herbal Polysaccharides in the Treatment of Pulmonary Fibrosis: Concept and Future Prospects

Huang

et al. 2021

Front. Pharmacol.

Pulmonary fibrosis is a fatal chronic progressive respiratory disease, characterized by continuous scarring of the lung parenchyma, leading to respiratory failure and death. The incidence of PF has increased over time. There are drugs, yet, there are some limitations. Hence, it is of importance to find new therapies and new drugs to replace the treatment of pulmonary fibrosis. In recent years, there have been a great number of research reports on the treatment of traditional Chinese medicine polysaccharides in various system fields. Among them, the treatment of PF has also gained extensive attention. This review summarized the source of polysaccharides, the drug activity of traditional Chinese medicine, and the protective effects on targets of Pulmonary fibrosis. We hope it can inspire researchers to design and develop polysaccharides, serving as a reference for potential clinical therapeutic drugs.