At the present stage of social development, which is forming a new high-tech world system with all its challenges and problems, it is necessary to provide all participants in social and economic relations with a single and convenient environment for interaction, to improve the level and quality of life, and to ensure sustainable development. «Smart city» technologies, and their further extrapolation to the scale of a regional entity – a «smart region» – make it possible to ensure sustainable development for all residents of the region and consumers of municipal and regional services – citizens, public and business organizations, as well as government. Due to the constant development of the transport industry and new opportunities for the transportation of passengers and goods, it is interesting to study the transport and logistics segment of the «smart region». It explains the relevance and practical significance of this study, which presents a theoretical and methodological substantiation of the formation of a «smart» transport and logistics complex with its positioning as a factor of sustainable development of the region, on the example of the Volgograd region. This approach is original, has a high degree of reliability, the ability to build and verify the forecast of the socio-economic development of the region. The developed model in the study represents the authors' vision of the development of the transport and logistics complex of the Volgograd region in the future, defines short, medium and long-term priorities, goals and objectives, proposes the main directions of development, mechanisms for achieving the set goals and objectives, taking into account the achieved level and identified problems. The results of approbation prove the expediency of its use in the development and scientific substantiation of the strategy of socio-economic development at the regional level.