A novel electrochemical sensor based on LaNi 0.5-Ti 0.5 O 3 /CoFe 2 O 4 nanoparticle-modified electrode (LNT-CFO/GCE) for sensitive determination of paracetamol (PAR) was presented. Experimental conditions such as the concentration of LNT-CFO, pH value, and applied potential were investigated. Under the optimum conditions, the electrochemical performances of LNT-CFO/GCE have been researched on the oxidation of PAR. The electrochemical behaviors of PAR on LNT-CFO/GCE were investigated by cyclic voltammetry. The results showed that LNT-CFO/GCE exhibited excellent promotion to the oxidation of PAR. The over-potential of PAR decreased significantly on the modified electrode compared with that on bare GCE. Furthermore, the sensor exhibits good reproducibility, stability, and selectivity in PAR determination. Linear response was obtained in the range of 0.5 to 901 μM with a detection limit of 0.19 μM for PAR.