Structure, degradation, drug release and mechanical properties relationships of iron-based drug eluting scaffolds: The effects of PLGA

Yusop, Abdul Hakim Md; Sarian, Murni Nazira; Januddi, Fatihhi; Ahmed, Qamar Uddin; Kadir, Mohammed Rafiq Abdul; Hartanto, Djoko; Hermawan, Hendra; Nur, Hadi

doi:10.1016/j.matdes.2018.09.019

Cited by 28 publications

(35 citation statements)

References 67 publications

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“…In studies, Yusop et al used poly-L-lactic acid with different curcumin amounts as a coating for iron scaffolds [ 156 ]. This research looked at bone implants; hence the role of curcumin is to retard the growth of osteosarcoma cells owing to cancer arrest.…”

Section: Iron Materials Modificationsmentioning

confidence: 99%

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

2021

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Iron, while attracting less attention than magnesium and zinc, is still one of the best candidates for biodegradable metal stents thanks its biocompatibility, great elastic moduli and high strength. Due to the low corrosion rate, and thus slow biodegradation, iron stents have still not been put into use. While these problems have still not been fully resolved, many studies have been published that propose different approaches to the issues. This brief overview report summarises the latest developments in the field of biodegradable iron-based stents and presents some techniques that can accelerate their biocorrosion rate. Basic data related to iron metabolism and its biocompatibility, the mechanism of the corrosion process, as well as a critical look at the rate of degradation of iron-based systems obtained by several different methods are included. All this illustrates as the title says, what was done within the topic of biodegradable iron-based materials and what more can be done.

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Section: Iron Materials Modificationsmentioning

confidence: 99%

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

2021

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“…Other reports have been made confirming that drug release could be affected by the rate of degradation. A study by Yusop et al showed that curcumin release was affected by the addition of iron to scaffolds; as such, a modification was able to enhance the degradation of poly(lactic-co-glycolic acid) scaffolds [41].…”

Section: Vegf Releasementioning

confidence: 99%

Assessment of the Release of Vascular Endothelial Growth Factor from 3D-Printed Poly-ε-Caprolactone/Hydroxyapatite/Calcium Sulfate Scaffold with Enhanced Osteogenic Capacity

Chen

Wang

et al. 2020

Polymers

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Vascular endothelial growth factor (VEGF) is one of the most crucial growth factors and an assistant for the adjustment of bone regeneration. In this study, a 3D scaffold is fabricated using the method of fused deposition modeling. Such a fabricated method allows us to fabricate scaffolds with consistent pore sizes, which could promote cellular ingrowth into scaffolds. Therefore, we drafted a plan to accelerate bone regeneration via VEGF released from the hydroxyapatite/calcium sulfate (HACS) scaffold. Herein, HACS will gradually degrade and provide a suitable environment for cell growth and differentiation. In addition, HACS scaffolds have higher mechanical properties and drug release compared with HA scaffolds. The drug release profile of the VEGF-loaded scaffolds showed that VEGF could be loaded and released in a stable manner. Furthermore, initial results showed that VEGF-loaded scaffolds could significantly enhance the proliferation of human mesenchymal stem cells (hMSCs) and human umbilical vein endothelial cells (HUVEC). In addition, angiogenic- and osteogenic-related proteins were substantially increased in the HACS/VEGF group. Moreover, in vivo results revealed that HACS/VEGF improved the regeneration of the rabbit’s femur bone defect, and VEGF loading improved bone tissue regeneration and remineralization after implantation for 8 weeks. All these results strongly imply that the strategy of VEGF loading onto scaffolds could be a potential candidate for future bone tissue engineering.

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“…Recently, biodegradable metals have been vigorously studied as they offer several advantages over non‐biodegradable metals. Besides offering higher mechanical strengths over polymeric and ceramic‐based implants counterparts, biodegradable metals could abrogate the necessity of second removal surgery and could circumvent the long‐term negative effects of permanent implantation 1 . Iron (Fe), magnesium (Mg), zinc (Zn), and their alloys are the current three biodegradable metals families.…”

Section: Introductionmentioning

confidence: 99%

“…Since it provides a local release, it offers a higher efficiency on the dose control over a specific targeted tissue and reduces the side effects to non‐targeted tissues as compared to the systemic drug delivery method 14 . An absorbable drug‐eluting stent that releases anti‐proliferative drug on smooth muscle cells 15 and a bone scaffold that delivers anticancer drugs 1 are the basis of this drug‐device system.…”

Section: Introductionmentioning

confidence: 99%

Degradation‐triggered release from biodegradable metallic surfaces

et al. 2021

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This work is dedicated to the investigation of drug‐release control by a direct effect of degradation from biodegradable metallic surfaces. Degradation behaviors characterized by surface morphology, immersion, and electrochemical techniques demonstrated that curcumin‐coated zinc (c‐Zn) had a higher degradation rate compared to curcumin‐coated Fe (c‐Fe). High anodic dissolution rate due to the higher degradation rate and widely extended groove‐like degradation structure of c‐Zn propelled a higher curcumin release. On the other hand, a slower curcumin release rate shown by c‐Fe scaffolds is ascribed to its lower anodic dissolution and to its pitting degradation regime with relatively smaller pits. These findings illuminate the remarkable advantage of different degradation behaviors of degradable metallic surfaces in directly controlling the drug release without the need for external electrical stimulus.

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Structure, degradation, drug release and mechanical properties relationships of iron-based drug eluting scaffolds: The effects of PLGA

Cited by 28 publications

References 67 publications

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

Assessment of the Release of Vascular Endothelial Growth Factor from 3D-Printed Poly-ε-Caprolactone/Hydroxyapatite/Calcium Sulfate Scaffold with Enhanced Osteogenic Capacity

Degradation‐triggered release from biodegradable metallic surfaces

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