Structures of six new compounds from Ligularia brassicoides

Constituents of Ligularia brassicoides Collected in China: A New Diels-Alder Adduct of Eremophilan-10βol and Methacrylic Acid

“…The compounds isolated from the four samples of L. brassicoides used in this study were less oxidized than those from two samples collected in southern Sichuan [3]. Especially there was no oxygen function at C-3 for any of the compounds isolated in this work.…”

“…-Mazz (Asteraceae) grows on grassy slopes at 2600-3100 m als in south-western and western Sichuan, China [2]. We previously collected two samples of L. brassicoides in 2007 in southern Sichuan Province and found six new sesquiterpenoids bearing eremophilane, bakkane, and seco-eremophilane skeletons [3]. Since then, four samples of L. brassicoides were collected in August 2011 in northwestern Sichuan Province.…”

Eremophilane Sesquiterpenes from the Genus Ligularia

“…Bakkenolide A ( 456 ) obtained from various species exhibited effective antitumor activity: IC 50 25.5, 38.1 and 56.7 μg/ml against HL‐60, human hepatoma cells (BEL‐7402), and human ovarian neoplasm cells (HO‐8910) . Compound 464 isolated from Ligularia brassicoides showed moderate cytotoxicity against HeLa and HL‐60 with IC 50 35.0 and 6.7 μ m , while other compounds exhibited weak or no activities . Ligulolide A ( 465 ) isolated from L. virgaurea subsp.…”

Terpenoids from Ligularia virgaurea collected in China: the first example of two bakkane derivatives with an anhydride-type ring C and nineteen new chemical constituents

“…A similar discussion was reported for all of the 9-oxofuranoeremophilane compounds ever isolated. [9][10][11][12] The angeloyloxy group was substituted at C-6 as indicated by the chemical shift (δH 6.11, δC 72.1) ( Table 6). The NOE between H-6α and H-4α indicated the stereochemistry for this compound.…”