Studi Klinis Ramuan Jamu Antihipertensi pada Pasien Hipertensi Derajat I

Triyono, Agus; Zulkarnain, Zuraida; Mana, Tofan Aries

doi:10.22435/jki.v8i1.6443.17-25

Cited by 10 publications

(12 citation statements)

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“…[9][10][11][12][13][14][15][16] Selain itu, dalam hasil Saintifikasi Jamu disimpulkan bahwa C. asiatica merupakan salah satu komponen ramuan antihipertensi. 17,18 Dalam usaha Saintifikasi Jamu dan menjaga kualitas bahan baku tumbuhan obat yang mengandung C. asiatica, ada beberapa tahapan yang harus dilakukan, salah satu yang terpenting adalah autentikasi dari bahan baku tumbuhan obat, secara makroskopis, mikroskopis, dan profil kimia.…”

Section: Pendahuluanunclassified

Autentikasi Centella asiatica (L.) Urb. (Pegagan) dan Adulterannya Berdasarkan Karakter Makroskopis, Mikroskopis, dan Profil Kimia

Maruzy

Budiarti

Subositi

2020

jki

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Pegagan or Centella asiatica (L.) Urb. empirically used as medicinal plant and scientifically can be used as antihypertension based on the results of the Jamu Saintification. Raw materials from C. asiatica have the potential to occur adulteration or incorrect use of plants species. There are two species of plants that have the potential to become adulterants of C. asiatica, namely Hydrocotyle verticillata and Merremia emarginata. Thus, the purpose of this study is to authenticate from Pegagan by comparing the macroscopic, microscopic, and chemical profiles of C. asiatica, H. verticillata, and M. emarginata. The method of data collection is done by purposive sampling using form intruments to record macroscopic and microscopic characters, while the chemical profiles are tested using thin layer chromatography methods to determine the content of asiaticosides in both potential adulterants species. The research was conducted at three sampling points: Central Java (Tawangmangu), West Java (Bogor), and East Java (Malang), while for laboratory research activities carried out at B2P2TOOT, Tawangmangu. The results showed macroscopically unique and easy distinguishing characters between C. asiatica and potential adulterant species H. verticillata is a leaf shape, whereas C. asiatica with M. emarginata are leaf-type appearance characters. The character of the simplicia leaf shape between C. asiatica and H. verticillata can be a distinct differentiator characters. Anatomical characters and powder fragments that can be used as a differentiator characters between C. asiatica and H. verticillata are the presence of pith on the stalk and stolon, the type of stomata, and the presence of trichomes. Authentication of simplicia powder of H. verticillata as an adulterant potential of C. asiatica with TLC, can be easily known by the absence of asiaticosides in these simplicia so that H. verticillata cannot be a substitute species for C. asiatica

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Section: Pendahuluanunclassified

Autentikasi Centella asiatica (L.) Urb. (Pegagan) dan Adulterannya Berdasarkan Karakter Makroskopis, Mikroskopis, dan Profil Kimia

Maruzy

Budiarti

Subositi

2020

jki

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“…Minum obat tradisional menjadi salah satu alasan ketidakpatuhan minum obat hipertensi (Badan Litbangkes Kemenkes RI, 2019). Studi ramuan jamu hipertensi (seledri, pegagan, temulawak, kunyit, meniran), terbukti aman dan berkhasiat untuk mengobati penderita hipertensi derajad I (Triyono, Zulkarnain and Mana, 2018). Studi lain tentang penggunaan obat herbal sebagai terapi hipertensi menunjukkan bahwa dari 70,9% pasien hipertensi di puskesmas menggunakan obat herbal, hanya 15,2% pasien yang menggunakan herbal dengan kriteria jamu sesuai peraturan Badan Pengawas Obat dan Makanan (BPOM) (Paramita et al, 2017).…”

Section: Sepuluh Besar Provinsi Dengan Masyarakat Memanfaatkan Yankestradunclassified

Posisi Relatif Provinsi di Indonesia Berdasarkan Penggunaan Pengobatan Tradisional: Analisis Komponen Utama Biplot

Kristiana

Paramita

Andarwati

et al. 2020

hsr

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The utilization of traditional health services and the use of traditional medicine in Indonesia is still high. There are socio-cultural-natural resources connection in the use of traditional health services and traditional medicine. This study examines Basic Health Research (Riskesdas) 2018 data relating to Indonesia's top ten provinces' relative position, whose community exercises self-traditional health practices and utilizing traditional health services. The analysis was conducted by using PCA-Biplots. Results showed similarities between North Maluku-Maluku-West Papua; Central Sulawesi-South Sulawesi-East Nusa Tenggara-Papua; Special Region of Yogyakarta-Central Java-East Java; South Kalimantan-Banten, while the others were scattered. The utilization of TOGA had a positive correlation with the utilization of traditional medicines. The result of variable diversity identification showed that the community utilizes traditional health services (83.29%) was higher than community exercising self-traditional health practices (73.19%). Actively monitoring, improving information sharing, and educating people on traditional medicine applications, particularly non-communicable disease issues, should be done according to traditional medicine variables' main characteristics in the region. Traditional medicine should serve promotive and preventive health initiatives, as its efficacy in therapeutic use is still debatable. Abstrak Pemanfaatan pelayanan Kesehatan tradisional (yankestrad) dan penggunaan obat tradisional masih cukup banyak. Terdapat keterkaitan sosial, budaya, dan sumber daya alam dalam pemanfaatan yankestrad dan penggunaan pengobatan tradisional lokal. Penelitian ini menganalisis posisi relatif 10 besar provinsi di Indonesia yang melakukan upaya kestrad sendiri dan memanfaatkan yankestrad berdasarkan data Riskesdas 2018. Analisis posisi relatif dalam artikel ini adalah PCA-Biplot. Hasil analisis menunjukkan pola pengelompokan kemiripan sebagai berikut: Malut-Maluku-Pabar; Sulteng-Sulsel-NTT-Papua; DIY-Jateng-Jatim; Kalsel-Banten, dan lainnya tersebar. Variabel pemanfaatan TOGA, semakin positif variabel, maka diikuti oleh pemanfaatan obat tradisional yang semakin baik. Hasil identifikasi keragaman variabel pada pengelompokan 10 besar provinsi dengan masyarakat memanfaatkan yankestrad (83,29%) mempunyai nilai lebih tinggi daripada masyarakat melakukan upaya kestrad sendiri (73,19%). Pemerintah melalui dinas terkait harus melakukan pemantauan, pemberian informasi dan edukasi pengobatan tradisional khususnya untuk penyakit tidak menular dengan penyesuaian terhadap karakteristik pemanfaatan pengobatan tradisional di wilayah tersebut.

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“…Di RRJ, berdasarkan penelitian sebelumnya pada 492sampel yang mengalami hipertensi terdapat kadar kolesterol abnormal sebanyak 52,4% dengan kadar rata-rata 247,2mg/dl [6]. Ramuan antihipertensi telah terbukti efektif dalam menurunkan tekanan darah dalam uji klinis tahun 2012 [7]. Ramuan antihiperkolesterolemia juga terbukti dapat menurunkan kadar kolesterol dalam uji klinis tahun 2015 [8].…”

Section: Pendahuluanunclassified

“…Mekanisme ramuan jamu antihipertensi dalam mengontrol tekanan darah antara lain,memberikan efek diuretic serta efek dilatasi pada pembuluh darah dan menghambat angiotensin converting enzym (ACE). Penghambatan sistem Rata-rata TDS Rata-rata TDD renin-angiotensin dapat menurunkan kemampuan ginjal dalam meningkatkan tekanan darah [7].…”

Section: Hasil Dan Pembahasanunclassified

Efek Kombinasi Ramuan Jamu Terhadap Tekanan Darah dan Kolesterol Pasien di Rumah Riset Jamu Hortus Medicus

Astana

Novianto

Triyono

2018

Self Cite

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Hipertensi dan hiperkolesterolemia masih merupakan masalah di bidang kesehatan. Penanganan pasien hipertensi yang disertai hiperkolesterolemia memerlukan perhatian khusus. Di Rumah Riset Jamu (RRJ) terdapat banyak pasien hipertensi dengan hiperkolesterolemia yang diterapi menggunakan kombinasi ramuan jamu antihipertensi dan antihiperkolesterolemia. Penelitian ini bertujuan untuk mengetahui efek kombinasi ramuan jamu tersebut dalam menurunkan tekanan darah dan kadar kolesterol. Penelitian ini dilakukan menggunakan metode kohort retrospektif. Sampel didapatkan dari data rekam medik pasien hipertensi yang disertai hiperkolesterolemia di RRJ Hortus Medicus tahun 2017. Subjek penelitian ini adalah pasien yang berusia 20-65 tahun dan telah menjalani terapi kombinasi ramuan jamu antihipertensi dan antihiperkolesterol minimal 28 hari. Analisis dilakukan dengan membandingkan tekanan darah dan kadar kolesterol pasien pada hari ke-0 dan hari ke-28 masing-masing menggunakan uji t berpasangan. Sebanyak 223 data pasien didapatkan. Setelah 28 hari, terdapat 74 orang yang berhasil mencapai tekanan darah normal dan 115 orang berhasil mencapai kadar kolesterol normal. Tekanan darah sistolik berbeda secara signifikan antara sebelum dan setelah pemberian ramuan jamu, p=0,000. Demikian juga tekanan darah diastolik berbeda secara signifikan antara sebelum dan setelah pemberian ramuan jamu p=0,005. Kadar kolesterol di dalam darah pasien juga berbeda secara signifikan antara sebelum dan setelah pemberian ramuan jamu, p=0,014. Berdasarkan hasil di atas, dapat disimpulkan bahwa pemberian kombinasi ramuan jamu antihipertensi dan antihiperkolesterolemia selama 28 hari dapat menurunkan tekanan darah dan kadar kolesterol pasien secara signifikan. Hypertension and hypercholesterolemia are still a health problem. Treatment of hypertensive patients comorbid with hypercholesterolemia requires special attention. At the Jamu Research House (RRJ) there are many hypertensive patients with hypercholesterolemia who are treated using a combination of antihypertensive and antihypercholesterolemic herbs. This study aimed to determine the effect of the combination of jamu in lowering blood pressure and cholesterol levels. This study was conducted using a retrospective cohort method. Samples were obtained from medical record of hypertensive patients comorbid with hypercholesterolemia at RRJ Hortus Medicines in 2017. The subjects of this study were patients aged 20-65 years and had undergone a combination therapy of antihypertensive and antihypercholesterolemicjamu at least 28 days. The analysis was carried out by comparing the blood pressure and cholesterol levels of patients on day 0 and day 28 using paired t test. A number of 223 patient data were obtained. After 28 days, there were 74 people who reach normal blood pressure and 115 people achieve normal cholesterol levels. Systolic blood pressure was significantly different between before and after the administration of jamu, p = 0,000. Likewise, diastolic blood pressure was significantly different between before and after the administration of jamu with p = 0.005. Cholesterol levels in the patient's blood also differed significantly between before and after administration of jamu formula, p = 0.014. Based on the above results, it can be concluded that the combination of antihypertensive and antihypercholesterolemic jamu for 28 days significantly reduced blood pressure and patient cholesterol levels

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Studi Klinis Ramuan Jamu Antihipertensi pada Pasien Hipertensi Derajat I

Cited by 10 publications

References 0 publications

Autentikasi Centella asiatica (L.) Urb. (Pegagan) dan Adulterannya Berdasarkan Karakter Makroskopis, Mikroskopis, dan Profil Kimia

Autentikasi Centella asiatica (L.) Urb. (Pegagan) dan Adulterannya Berdasarkan Karakter Makroskopis, Mikroskopis, dan Profil Kimia

Posisi Relatif Provinsi di Indonesia Berdasarkan Penggunaan Pengobatan Tradisional: Analisis Komponen Utama Biplot

Efek Kombinasi Ramuan Jamu Terhadap Tekanan Darah dan Kolesterol Pasien di Rumah Riset Jamu Hortus Medicus

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