Studies of Nephritis in Children

Abstract

Volhard. He, as well as Epstein,7 repeatedly pointed to a general metabolic disturbance, perhaps of the ductless glands, as a cause of this disease, and that these cases do not seem to be primarily a disease of the kidney. Symptoms: Onset.-In some of our cases there was a history of pallor or a generally subnormal condition existing for some months previously. In a few cases there was a distinct history of malaise, vomiting and headache; in the majority of cases, however, the first symptom noticed by the parents, was the swelling about the face, the edema increasing with great rapidity. In ten cases the edema began in the face and within twenty-four hours the legs were involved. In other cases the edema of the legs and face occurred simultaneously, and in the course of about a week the other subcutaneous tissues were also involved.Temperature.-Temperature elevation was not usitaiiy present, and the children were not acutely ill ; the throat was generally in fairly 6.

Plasma Lipids in Chronic Hemorrhagic Nephritis

“…All cases of this type showed total colorimetric cholesterol values markedly above normal, while no other cases did. Confirmative results from 2 cases of nephrotic and 21 of non-nephrotic Bright's disease were published by Port (1919), from 5 cases of nephrosis and 13 of glomerulonephritis by Hahn and Wolff (1921), and from 17 cases of nephrosis by Schwarz and Kohn (1922). Westphal (1924-5) found high serum total cholesterol (250 to 430 mgm.)…”

A Long Term Study of the Variation of Serum Cholesterol in Man 1

“…A fall in blood cholesterol has been noted previously with thyroid administration (5,7,13) although it has been emphasized that this fall does not occur in nephrosis (12,17).…”