Studies of Urea Excretion

Slyke, Donald D. Van; McIntosh, John F.; Möller, E; Hannon, R. R.; Johnston, C.

doi:10.1172/jci100269

Cited by 46 publications

(8 citation statements)

References 4 publications

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“…The blood urea clearance varies with the mass of functioning renal tissue (Hayman et al, 1939 ; MacKay, 1932 a, b). As renal damage increases, the blood urea clearance approaches the glomerular filtration rate, which itself is reduced, and also becomes less variable (Chasis and Smith, 1938 ;Van Slyke et al, 1930 ;Winkler and Parra, 1937) ; but it has been claimed that over 50 per cent. of the renal tissue may be destroyed before the blood urea clearance is depressed (Peters and Van Slyke, 1946) and that the blood urea clearance may fall to 20 to 40 per cent.…”

Section: Discussionmentioning

confidence: 99%

“…of the renal tissue may be destroyed before the blood urea clearance is depressed (Peters and Van Slyke, 1946) and that the blood urea clearance may fall to 20 to 40 per cent. of normal before the blood urea begins to rise (MacKay and MacKay, 1927 ;Moller et al, 1928 ;Van Slyke et a/., 1930). Bruck et al (1954 found that even when the blood urea clearance was markedly reduced, it was still very variable, and could not be used as an accurate measure of the glomerular filtration rate.…”

Section: Discussionmentioning

confidence: 99%

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THE BLOOD UREA CLEARANCE and RENAL FUNCTION

Eastham

1957

British Journal of Urology

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SUMMARY A critical assessment of theoretical aspects of the blood urea clearance as a test of renal function has been presented. The simple blood urea clearance test is not a satisfactory measure of renal function. Urine urea excretion is influenced by the diet, and therefore the diet has a very great effect on the blood urea clearance. There is an upper limit of blood urea concentration above which on normal diets it is physically impossible for a normal blood urea clearance to be obtained. Some anomalies arising from the blood urea clearance formulae have been demonstrated. Thus blood urea concentration and renal function appear to be simply inversely proportional. Also where the urine flow is less than 2 ml. per minute, the kidney appears to become less efficient as the urine flow increases and vice versa.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

THE BLOOD UREA CLEARANCE and RENAL FUNCTION

Eastham

1957

British Journal of Urology

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“…The concentration of urea in blood is a bad estimator of GFR. Thus, it may be reduced to about 35-40% before retention of urea in blood occurs (van Slyke, McIntosh, Moller, Hannon & Johnston, 1930;Hayman, Martin & Miller, 1939).…”

Section: (Ylkg Body Weight)mentioning

confidence: 99%

Sublimate Intoxication of Rat: A Pilot Scheme of Mortality and Renal Damage According to the Amount of Sublimate

1970

Scandinavian Journal of Urology and Nephrology

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A series of rats was given different doses of sublimate as a one-time subcutaneous injection. The greatest polyuric effect without retention of urea, morphological renal damage, or mortality was obtained with 4 mg sublimate per kg body weight. Given 10 mg sublimate per kg body weight or more, all rats were rendered oliguric or anuric with extensive necrosis of the cells of the proximal tubules of the kidneys. Most of these rats died during the experimental period of 5 days. Support is given to the theory that sublimate intoxication affects both the glomerular filtration rate and the tubular reabsorption rate. Polyuria may thus be attributable to a discrepency between these two functions. Oliguria and anuria seem to be caused by a severe impairment of the glomerular function. Scand J Urol Nephrol4Scand J Urol Nephrol Downloaded from informahealthcare.com by McMaster University on 12/26/14For personal use only. -1961. Studies on the excretion of mercury in the kidneys. Acta Path Microbiol Scand, Suppl. 144, 115-117. Bloom, W. & Fawcett, D. W. 1962. A textbook of histology, 8th ed., p. 25. Saunders, Philadelphia and London. Cafruny, E. J. 1963. Histochemical demonstration of mercury in renal cells. In Proceedings of the first international pharmacological meeting, vol. 5 , pp. 15-21. Pergamon press, Oxford, London, New York and Paris. Cohen, E. M., Groot, C. A. de & Weber, J. F. 1954. The influence of mersalyl on phosphate metabolism in kidney slices from intravenously injected rats. Acra Physiol Pharmacol Need 3, 512-521. -1955. Influence of mersalyl on phosphate metabolism in kidney slices of intramuscularly injected rats. Acta Physiol Pharmacol Need 4, 1-8. Conn, H. L., Jr, Anderson, W. & Arena, S. 1953. Gas diffusion technique for measurement of renal blood flow with special reference to the intact, anuric subject. J Appl Physiol 5, 683689. COM, H. L., Jr, Wilds, L. & Helwig, J. 1954. A study of the renal circulation, tubular function and morphology, and urinary volume and composition in dogs following mercury poisoning and transfusion of human blood. J Clin Invest 33, 132-141. Flanigan, W. J. & Oken, D. E. 1965. Renal micropuncture study of the development of anuria in the rat with mercury-induced acute renal failure. J Clin Znvest 44,, 449-451. Scand J Urol Nephrol4

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“…In the individual patient this cannot safely be done. True, when we plot the blood urea concentrations of a large number of patients against their urea clearances, a general relation does emerge (1,2). However, in any one of such a group of patients the prediction from concentration to clearance may fall dangerously far from the truth.…”

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confidence: 97%