Study of Glycated Haemoglobin (HbA1c) In Non-Diabetic Subjects with Subclinical Hypothyroidism

Makadia, Mayur Goradhanbhai; Patel, Vishwal Indravadan; Patel, Kaustubh; Shah, Aashna Darshanbhai; Chaudhari, K. S.; Shah, Hitesh; Nilayangode, Haridas Neelakandan

doi:10.7860/jcdr/2017/22600.9479

Cited by 8 publications

(11 citation statements)

References 22 publications

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“…This finding was consistent with the results of Khalid et al, who did not find any association between T2DM and hypothyroidism [ 18 ]. Our finding was in contrast to the findings of Ezeani et al [ 16 ], Cho et al [ 19 ], and Makadia et al [ 20 ], who found a strong association of HbA1c with thyroid dysfunction. We demonstrated no association between SCH and poor glycemic control in patients with T2DM.…”

Section: Discussioncontrasting

confidence: 99%

Lack of Association between Poor Glycemic Control in T2DM and Subclinical Hypothyroidism

Sharma

Sinha

Prasad

et al. 2020

Journal of Thyroid Research

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Background. Hypothyroidism is a highly prevalent and multifactorial disorder and has been implicated in the causation of dyslipidemia, dermatological diseases, atherosclerosis, and myocardial dysfunction, as well as endothelial dysfunction. The relationship between subclinical hypothyroidism and type 2 diabetes mellitus is not well established. In the present study, we attempt to find out the prevalence of subclinical hypothyroidism in type 2 diabetes mellitus and its association with glycemic control. Materials and Methods. This was an observational study in which 205 consecutive patients of T2DM visiting the outpatient department of medicine were recruited. Serum TSH, free thyroxine, free triiodothyronine, and lipid profile, as well as HbA1c assays, were done in the study participants, and they were categorized into three groups by HbA1c: <7%, 7–9%, and >9%. Results. There is a high prevalence of subclinical hypothyroidism in type 2 DM patients. Mean HbA1c in diabetics without SCH was 7.89%, whereas it was 8.33% in diabetics with SCH. This difference was statistically not significant. TSH was not found to be significantly associated with HbA1c. Conclusion. High prevalence of SCH in T2DM patients suggests that there is a need for regular follow-up to check the progression of SCH to overt hypothyroidism. High serum TSH is not a predictor of poor glycemic control.

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Section: Discussioncontrasting

confidence: 99%

Lack of Association between Poor Glycemic Control in T2DM and Subclinical Hypothyroidism

Sharma

Sinha

Prasad

et al. 2020

Journal of Thyroid Research

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“…In the present study, we found a significant positive association between subclinical hypothyroidism and HbA1c ( Table 3 ). This is consistent with the findings of a previous study that reported the levels of HbA1c in non-diabetic participants with subclinical hypothyroidism to be higher than those in normal healthy controls [ 7 ].…”

Section: Discussionsupporting

confidence: 93%

“…Another cross-sectional study reported that the levels of HbA1c in non-diabetic participants with subclinical hypothyroidism were significantly higher than those in normal healthy controls [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…As the absence of thyroid cysts might indicate latent damage to the thyroid [ 5 ] and a lower productivity of thyroid hormone [ 8 ] and subclinical hypothyroidism might cause HbA1c elevation [ 7 ], HbA1c could be inversely associated with thyroid cysts among participants with normal thyroid function. However, no study has reported these associations.…”

Section: Introductionmentioning

confidence: 99%

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HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study

et al. 2021

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Anti-thyroid peroxidase antibody (TPO-Ab) is revealed to be inversely associated with thyroid cysts among euthyroid population. TPO-Ab causes autoimmune thyroiditis by bolstering thyroid inflammation. Therefore, at least partly, absence of thyroid cysts could indicate latent thyroid damage. Since participants with subclinical hypothyroidism are reported to have higher HbA1c than normal healthy controls, HbA1c could be inversely associated with thyroid cysts through a mechanism reflecting latent thyroid damage. To investigate the association between HbA1c and thyroid cysts among a euthyroid population, a cross-sectional study was conducted on 1,724 Japanese individuals who were within the normal range of thyroid function [i.e., normal range of free triiodothyronine (T3) and free thyroxine (T4)] and aged 40–74 years. Among this study population, 564 were diagnosed with thyroid cysts. Independently of thyroid related hormones [thyroid stimulating hormone (TSH), free T3, and free T4] and known cardiovascular risk factors, HbA1c was found to be significantly inversely associated with the presence of thyroid cysts. This association remained significant even after this analysis was limited to participants within a normal range of TSH. The fully adjusted odds ratios (ORs) of thyroid cysts for 1 standard deviation (SD) increment of HbA1c were 0.84 (0.74, 0.95) for total participants and 0.80 (0.70, 0.92) for participants within a normal range of TSH. Among participants with normal thyroid function, HbA1c was inversely associated with the presence of thyroid cysts. The absence of thyroid cysts and higher levels of HbA1c could indicate the latent functional damage of the thyroid.

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“…[14][15][16][17] A significant correlation between TSH and HbA1c serum levels has also been found. 18 Low RBC turnover, with a predominance of older cells are associated with a falsely elevated HbA1c. Proven examples include iron and vitamin B12 deficiencies and renal failure.…”

Section: Introductionmentioning

confidence: 99%

Thyroid hormones, blood glucose and glycosylated hemoglobin in healthy Sudanese subjects

et al. 2019

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Background: Diabetes mellitus and thyroid diseases are the most prevalent metabolic disorders in Sudan. The value of HbA1C reflects the glycemic status over the last 2-3 months. So, in this study, an insight for thyroid hormone regulation of glucose metabolism is investigated. Is to study the association between thyroid hormones levels, fasting blood sugar (FBS) and HbA1c in healthy adults.Methods: A cross sectional study was performed in a healthy Sudanese cohort in the period between September 2017 to November 2018, involving 610 healthy adult Sudanese aged 20 to 60 years. HbA1c, fasting blood sugar (FBS), T3, T4 and TSH were measured.Results: The study results demonstrated a significant association between the median concentration of T3 and T4 with plasma level of HbA1c. A significant linear correlation between serum concentration of T3 and fasting blood sugar (FBS) was observed. Inverse correlation was detected between serum TSH and HbA1c, FBS in study population.Conclusions: The present study concluded that FBS and HbA1c levels were increased with increasing of both T3 and T4. Based on this study all the thyroid patients’ especially hyperthyroid patients should have regular checkup of their glucose levels.

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Study of Glycated Haemoglobin (HbA1c) In Non-Diabetic Subjects with Subclinical Hypothyroidism

Abstract: Our data suggest that the non-diabetic subjects with SH show misleadingly high levels of the HbA1c. Therefore, the effect of altered levels of the serum TSH on the HbA1c must be considered when interpreting the HbA1c for the diagnosis of diabetes in the SH patients.

Cited by 8 publications

References 22 publications

Lack of Association between Poor Glycemic Control in T2DM and Subclinical Hypothyroidism

Lack of Association between Poor Glycemic Control in T2DM and Subclinical Hypothyroidism

HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study

Thyroid hormones, blood glucose and glycosylated hemoglobin in healthy Sudanese subjects

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