Study of Monarda Fistulosa Essential Oil as a Prospective Antiseborrheic Agent

Zhilyakova, E. T.; Новиков, О. О.; Науменко, Е. Н.; Krichkovskaya, L. V.; Киселева, Т. С.; Timoshenko, E. Yu.; Novikova, Marina; Litvinov, S A

doi:10.1007/s10517-010-0777-7

Cited by 15 publications

(8 citation statements)

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“…ex Lag. , and M. punctata L. ( Fraternale et al, 2006 ; Zhilyakova et al, 2009 ; Geffre et al, 2011 ; Tabanca et al, 2013 ; Thompson et al, 2013 ; Li et al, 2014 ; Mattarelli et al, 2017 ; Shanaida et al, 2018b ; Deepika et al, 2020 ; Ghosh et al, 2020 ; Marchioni et al, 2020 ).…”

Section: Introductionunclassified

“…Flambeau Ojibwe dried the whole aerial part of this plant and boiled it in a suitable vessel to obtain the essential oil for treatment of bronchial and catarrh conditions through inhalation ( Wagner, 2006 ). Later, it was found that M. fistulosa essential oil is the natural source of thymol and p -cymene with strong antiseptic properties ( Zhilyakova et al, 2009 ; Mattarelli et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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Polyphenols and Pharmacological Screening of a Monarda fistulosa L. dry Extract Based on a Hydrodistilled Residue By-Product

et al. 2021

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This study aimed to determine the composition and content of polyphenols in the dry extract obtained from the hydrodistilled residue by-product of the wild bergamot (Monarda fistulosa L., Lamiaceae Martinov family) herb (MFDE) and to evaluate its safety and pharmacological properties. The total phenolic content (TPC) in the MFDE was 120.64 mg GAE/g. The high-performance liquid chromatography (HPLC) analysis showed the presence of a plethora of phenolic compounds, including hydroxycinnamic acids and flavone derivatives in the MFDE, with rosmarinic acid and luteolin-7-O-glucoside being the main components. With an IC50 value of 0.285 mg/mL, it was found to be a strong DPPH radical scavenger. The acute toxicity study results indicate that the oral administration of MFDE to rats at the doses of 500–5,000 mg/kg did not produce any side effects or death in animals which indicates its safety. The results of the in vivo assay showed that the MFDE dose-dependently inhibited paw oedema and significantly reduced the number of writings in mice induced by the acetic acid injection suggesting its potent anti-inflammatory and analgesic activities, respectively. The conducted studies revealed that M. fistulosa hydrodistilled residue by-product could be regarded as a new natural source of polyphenols with valuable pharmacological properties.

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Section: Introductionunclassified

Section: Introductionmentioning

confidence: 99%

Polyphenols and Pharmacological Screening of a Monarda fistulosa L. dry Extract Based on a Hydrodistilled Residue By-Product

et al. 2021

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“…Essential oils of Monarda species have been reported to be rich in oxygenated monoterpenes, leading to differentiation into the following chemotypes: thymol, carvacrol, borneol, and geraniol [ 10 ]. A literature survey regarding biological activities of the Monarda species essential oils and their major compounds, based on references [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ], is summarized in Table 1 .…”

Section: Introductionmentioning

confidence: 99%

Essential Oils from Monarda fistulosa: Chemical Composition and Activation of Transient Receptor Potential A1 (TRPA1) Channels

et al. 2020

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Little is known about the pharmacological activity of Monarda fistulosa L. essential oils. To address this issue, we isolated essential oils from the flowers and leaves of M. fistulosa and analyzed their chemical composition. We also analyzed the pharmacological effects of M. fistulosa essential oils on transient receptor potential (TRP) channel activity, as these channels are known targets of various essential oil constituents. Flower (MEOFl) and leaf (MEOLv) essential oils were comprised mainly of monoterpenes (43.1% and 21.1%) and oxygenated monoterpenes (54.8% and 77.7%), respectively, with a high abundance of monoterpene hydrocarbons, including p-cymene, γ-terpinene, α-terpinene, and α-thujene. Major oxygenated monoterpenes of MEOFl and MEOLv included carvacrol and thymol. Both MEOFl and MEOLv stimulated a transient increase in intracellular free Ca2+ concentration ([Ca2+]i) in TRPA1 but not in TRPV1 or TRPV4-transfected cells, with MEOLv being much more effective than MEOFl. Furthermore, the pure monoterpenes carvacrol, thymol, and β-myrcene activated TRPA1 but not the TRPV1 or TRPV4 channels, suggesting that these compounds represented the TRPA1-activating components of M. fistulosa essential oils. The transient increase in [Ca2+]i induced by MEOFl/MEOLv, carvacrol, β-myrcene, and thymol in TRPA1-transfected cells was blocked by a selective TRPA1 antagonist, HC-030031. Although carvacrol and thymol have been reported previously to activate the TRPA1 channels, this is the first report to show that β-myrcene is also a TRPA1 channel agonist. Finally, molecular modeling studies showed a substantial similarity between the docking poses of carvacrol, thymol, and β-myrcene in the binding site of human TRPA1. Thus, our results provide a cellular and molecular basis to explain at least part of the therapeutic properties of these essential oils, laying the foundation for prospective pharmacological studies involving TRP ion channels.

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“…Some kind of essential oils exhibited anti-oxidant [ 11 , 12 ], anti-hypoxic-ischemic [ 13 ], anti-bacterial and anti-fungal activities [ 14 ] muscle relaxant [ 15 ]. Lavender essential oil, volatile aromatic oily liquids isolated from Lavandula plants by various means, used as folk medicine possesses many therapeutic properties including anti-oxidant [ 16 ], antiinflammatory [ 17 ], antibacterial [ 18 ], anxiolytic and sedative action [ 19 ], antiplatelet and antithrombotic activities [ 20 ], antimutagenic activity [ 21 ], treatment agitation in patients with severe dementia [ 22 ]. But the protective effects of lavender oil against cerebral ischemia/reperfusion damage have not been evaluated.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Activity of Lavender Oil on Transient Focal Cerebral Ischemia in Mice

et al. 2012

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The air-dried aerial parts of Lavandula angustifolia Mill, a traditional Uygur herbal drug, is used as resuscitation-inducing therapy to treat neurodisfunctions, such as stroke. This study was designed to assess the neuroprotective effects of lavender oil against ischemia/reperfusion (IR) injury in mice. Focal cerebral ischemia was induced by the intraluminal occlusion method with a nylon string. The neurodysfuntion was evaluated by neurological deficit and the infarct area was showed by 2,3,5-triphenyltetrazolium chloride (TTC) staining. The histopathological changes were observed by hematoxylin and eosin staining. The levels of mitochondria-generated reactive oxygen species (ROS), malondialdehyde (MDA) and carbonyl, the ratio of reduced glutathione (GSH)/glutathione disulfide (GSSG), the activities of superoxide dismutase (SOD), catalase (CAT) and glutathion peroxidase (GSH-Px) in brain tissue were measured to estimate the oxidative stress state. Neurological deficit, infarct size, histopathology changes and oxidative stress markers were evaluated after 22 h of reperfusion. In comparison with the model group, treatment with lavender oil significantly decreased neurological deficit scores, infarct size, the levels of MDA, carbonyl and ROS, and attenuated neuronal damage, upregulated SOD, CAT, GSH-Px activities and GSH/GSSG ratio. These results suggested that the neuroprotective effects of lavender oil against cerebral ischemia/reperfusion injury may be attributed to its antioxidant effects.

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Study of Monarda Fistulosa Essential Oil as a Prospective Antiseborrheic Agent

Cited by 15 publications

References 1 publication

Polyphenols and Pharmacological Screening of a Monarda fistulosa L. dry Extract Based on a Hydrodistilled Residue By-Product

Polyphenols and Pharmacological Screening of a Monarda fistulosa L. dry Extract Based on a Hydrodistilled Residue By-Product

Essential Oils from Monarda fistulosa: Chemical Composition and Activation of Transient Receptor Potential A1 (TRPA1) Channels

Neuroprotective Activity of Lavender Oil on Transient Focal Cerebral Ischemia in Mice

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