Study of temperature and irradiation influence on the physicochemical properties of Aspirin

Al-Maydama, Hussein M.A.; Abduljabbar, Adlia A.; Al-Maqtari, Maher Ali; Naji, Khalid Mohammed

doi:10.1016/j.molstruc.2017.12.062

Cited by 5 publications

(7 citation statements)

References 20 publications

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“…[ 48 ] The peak at around 15.6° in ALBAN and AL‐PEG‐NP confirms the presence of aspirin. [ 49 ] The crystallite size was calculated using Debye–Scherrer's formula,

sans-serifD = sans-serifKλ / sans-serifβcosθ

…”

Section: Resultsmentioning

confidence: 99%

Enhancing the Aspirin Loading and Release Efficiency of Silver Oxide Nanoparticles Using Oleic Acid‐based Bio‐Surfactant from Enteromorpha intestinalis

Nazeer¹,

Saravanan

Chandar

et al. 2020

Applied Organom Chemis

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This study is an attempt to improve the loading and release potential of silver oxide nanoparticles (AgO NPs) using Oleic acid based bio-surfactant isolated from Enteromorpha instestinalis. The isolated Oleic acid based bio-surfactant was characterized using GC-MS, NMR, and HPLC. The AgO NPs were then surface-functionalized with the bio-surfactant and analyzed using XRD, HR-TEM/SAED, DLS, UV-Vis, and FTIR spectroscopy to evaluate the loading of aspirin and functional groups responsible for loading. The model drug Aspirin that has depreciated bio-availability due to poor solubility was used to test the drug carrier efficiency of the AgO NPs after the surface-functionalization. The loading of aspirin was increased by up to 80% in bio-surfactants than PEGcoated NPs (72%) at a 1:1 ratio (Aspirin/NP). The drug release profile of aspirin was evaluated by dialysis at different acidic conditions (pH 1.2, 6.8, and 7.4) and the active release of aspirin was observed in pH 6.8 and bio-surfactant produced better release than PEG and commercial tablet in all the pH conditions. To identify the mechanism of release from the carrier, the release kinetics was studied using zero-order, first-order, Higuchi's, and Korsmeyer Peppas equations and found that the release was time-dependent and non-fickian.

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“…[ 48 ] The peak at around 15.6° in ALBAN and AL‐PEG‐NP confirms the presence of aspirin. [ 49 ] The crystallite size was calculated using Debye–Scherrer's formula,

sans-serifD = sans-serifKλ / sans-serifβcosθ

…”

Section: Resultsmentioning

confidence: 99%

Enhancing the Aspirin Loading and Release Efficiency of Silver Oxide Nanoparticles Using Oleic Acid‐based Bio‐Surfactant from Enteromorpha intestinalis

Nazeer¹,

Saravanan

Chandar

et al. 2020

Applied Organom Chemis

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“…There are various publications within the literature, [78][79][80], indicating that thermal degradation/decomposition of aspirin occurs in two processes with the first process ranging from 160 to 260 °C. Furthermore, thermogravimetric analysis (TGA) studies conducted by Al-Maydama et al [81] and de A. Silva et al [82] deduced that the temperature of maximum degradation (TDTG) of aspirin occurred around 181 °C with further DSC studies conducted by de A. Silva et al [82] confirming this result. As can be observed in both Figure 7 and Figure 8, there was no endotherm observed for the dosages which contained either drug, paracetamol or aspirin, and either concentration, 2.50% or 5.00%, which is indicative of the active drug being entirely dissolved within the photopolymer solution.…”

Section: Thermal Characterizationmentioning

confidence: 84%

“…However, the second endotherm was noted at 179 • C (onset temperature 177 • C) may be attributed to the degradation of aspirin. There are various publications within the literature, [78][79][80], indicating that thermal degradation/decomposition of aspirin occurs in two processes with the first process ranging from 160 to 260 • C. Furthermore, thermogravimetric analysis (TGA) studies conducted by Al-Maydama et al [81] and de A. Silva et al [82] deduced that the temperature of maximum degradation (T DTG ) of aspirin occurred around 181 • C with further DSC studies conducted by de A. Silva et al [82] confirming this result.…”

Section: Thermal Characterizationmentioning

confidence: 99%

Additive Manufacturing of Personalized Pharmaceutical Dosage Forms via Stereolithography

et al. 2019

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The introduction of three-dimensional printing (3DP) has created exciting possibilities for the fabrication of dosage forms, paving the way for personalized medicine. In this study, oral dosage forms of two drug concentrations, namely 2.50% and 5.00%, were fabricated via stereolithography (SLA) using a novel photopolymerizable resin formulation based on a monomer mixture that, to date, has not been reported in the literature, with paracetamol and aspirin selected as model drugs. In order to produce the dosage forms, the ratio of poly(ethylene glycol) diacrylate (PEGDA) to poly(caprolactone) triol was varied with diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (Irgacure TPO) utilized as the photoinitiator. The fabrication of 28 dosages in one print process was possible and the printed dosage forms were characterized for their drug release properties. It was established that both drugs displayed a sustained release over a 24-h period. The physical properties were also investigated, illustrating that SLA affords accurate printing of dosages with some statistically significant differences observed from the targeted dimensional range, indicating an area for future process improvement. The work presented in this paper demonstrates that SLA has the ability to produce small, individualized batches which may be tailored to meet patients’ specific needs or provide for the localized production of pharmaceutical dosage forms.

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“…The crystallite size could be estimated from X-ray diffraction (XRD) patterns by applying full width at half maximum (FWHM) of the characteristic peaks using Debye-Scherrer Eq. 1 (Al-Maydama et al, 2018;Refat et al, 2014a; and Williamson-Hall Eq. 2 (Abed et al, 2019).…”

Section: Powder X-ray Diffraction Of the Ligand And Its Complexesmentioning

confidence: 99%

“…The percentage of crystallinity, Xc(%), was calculated on the basis of the integrated peak areas of the principal peaks (Al-Maydama et al, 2018). The crystallinity of the complex is calculated relative to the crystallinity of the ligand as a ratio (Eq.…”

Section: 𝑆𝑡𝑟𝑎𝑖𝑛 (𝜀) = 𝛽 Cos 𝜃 / Sin 𝜃mentioning

confidence: 99%

Synthesis, structural and spectroscopic properties of Co(II), Ni(II) and Cu(II) complexes with 2-((2-chlorobenzylidene)amino) acetohydrazide hydrate and their Antimicrobial and antioxidant activities

2023

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The current study was purposed to prepare Co(II), Ni(II) and Cu(II) complexes with the ligands derived from 2-chlorobenzaldehyde, glycine and hydrazine hydrate. The obtained compounds were characterized by different physicochemical studies such as elemental analysis, atomic absorption, molar ratio analysis, electronic absorption (UV-Vis spectroscopy), magnetic properties, FTIR spectroscopy, 1H�NMR, 13C-NMR, conductance measurements and XRD. Antimicrobial and antioxidant activities were also calculated. The antibacterial activity was evaluated by the diffusion method against two Gram-positive and two Gram-negative bacteria, while antifungal activity was assessed against two fungal strains by using the agar method. The ligand with Schiff base and hydrazide groups and its complexes showed better biological activity. The results showed that the most metal complexes have much higher antibacterial and antifungal activity compared to the parent ligand. The antioxidant activity of 3.7453 mg of the ligand exhibited excellent activity as the activity of 1 mg of ascorbic acid which is used as a standard antioxidant.

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Study of temperature and irradiation influence on the physicochemical properties of Aspirin

Cited by 5 publications

References 20 publications

Enhancing the Aspirin Loading and Release Efficiency of Silver Oxide Nanoparticles Using Oleic Acid‐based Bio‐Surfactant from Enteromorpha intestinalis

Enhancing the Aspirin Loading and Release Efficiency of Silver Oxide Nanoparticles Using Oleic Acid‐based Bio‐Surfactant from Enteromorpha intestinalis

Additive Manufacturing of Personalized Pharmaceutical Dosage Forms via Stereolithography

Synthesis, structural and spectroscopic properties of Co(II), Ni(II) and Cu(II) complexes with 2-((2-chlorobenzylidene)amino) acetohydrazide hydrate and their Antimicrobial and antioxidant activities

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