Study of the changes of trans-resveratrol caused by ultraviolet light and determination of trans- and cis-resveratrol in Spanish white wines

López-Hernández, J.; Paseiro-Losada, P.; Sanches-Silva, A.; Lage-Yusty, M. A.

doi:10.1007/s00217-006-0483-x

Cited by 55 publications

(36 citation statements)

References 39 publications

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“…The collected UV-visible spectra of two peaks ( Figure 11B) was found to be similar to literature data. 47 As shown in Figure 9, the encapsulation of RSV into NPs largely prevented its degradation with respect to free RSV. After 120 minutes of exposure, only 20% of trans isoform was detected in the reference sample (unencapsulated RSV), which was significantly reduced if compared with that obtained in the formulations.…”

mentioning

confidence: 86%

“…After 120 minutes, NP samples were collected by centrifugation, lyophilized, and the residue was dissolved in 1 mL of eluent mixture. RSV content was analyzed using the HPLC method previously reported, 47 with some modifications. of trans isomer (ie, RSV), namely the ratio of the content of compound retained in the original one in the samples.…”

Section: Rsv Protectionmentioning

confidence: 99%

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Development of novel cationic chitosan- and anionic alginate–coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol

Sanna¹,

Roggio²,

Siliani³

et al. 2012

IJN

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Background:Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of innovative formulation strategies, able to overcome physicochemical and pharmacokinetic limitations of this compound, may be achieved via suitable carriers able to associate controlled release and protection. In this context, nanotechnology is proving to be a powerful strategy. In this study, we developed novel cationic chitosan (CS)-and anionic alginate (Alg)-coated poly(d,l-lactide-co-glycolide) nanoparticles (NPs) loaded with the bioactive polyphenolic trans-(E)-resveratrol (RSV) for biomedical applications. Methods: NPs were prepared by the nanoprecipitation method and characterized in terms of morphology, size and zeta potential, encapsulation efficiency, Raman spectroscopy, swelling properties, differential scanning calorimetry, and in vitro release studies. The protective effect of the nanosystems under the light-stressed RSV and long-term stability were investigated. Results: NPs turned out to be spherical in shape, with size ranging from 135 to about 580 nm, depending on the composition and the amount of polyelectrolytes, while the encapsulation efficiencies increased from 8% of uncoated poly(d,l-lactide-co-glycolide) (PLGA) to 23% and 32% of Alg-and CS-coated PLGA NPs, respectively. All nanocarriers are characterized by a biphasic release pattern, and more effective controlled release rates are obtained for NPs formulated with higher polyelectrolyte concentrations. Stability studies revealed that encapsulation provides significant protection against light-exposure degradation, by reducing the trans-cis photoisomerization reaction. Moreover, the nanosystems are able to prevent the degradation of trans isoform and the leakage of RSV from the carrier for a period of 6 months. Conclusion: Our findings indicated that the newly developed CS-and Alg-coated PLGA NPs are suitable to be used for the delivery of bioactive RSV. The encapsulation of RSV into optimized polymeric NPs provides improved drug loading, effective controlled release, and protection against light-exposure degradation, thus opening new perspectives for the delivery of bioactive related phytochemicals to be used for (nano)chemoprevention/chemotherapy.

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mentioning

confidence: 86%

Section: Rsv Protectionmentioning

confidence: 99%

Development of novel cationic chitosan- and anionic alginate–coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol

Sanna¹,

Roggio²,

Siliani³

et al. 2012

IJN

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“…The distance from the irradiation front to the solution was fixed to be 60 cm. These conditions were optimized in a previous work carried out in our laboratory [21]. The concentrations of the cis-isomers were based on the assumption that the decrease in the peak area of the trans-isomers was proportional to the area of the cis-isomers formed.…”

Section: Chemicals and Standard Solutionsmentioning

confidence: 99%

Analysis of non‐anthocyanin phenolic compounds in wine samples using high performance liquid chromatography with ultraviolet and fluorescence detection

Quirós

López-Hernández²,

Ferraces-Casais

et al. 2007

J of Separation Science

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Analysis of non-anthocyanin phenolic compounds in wine samples using high performance liquid chromatography with ultraviolet and fluorescence detection A simple and rapid HPLC method with UV and fluorescence detection (FLD) for the separation of ten phenolic compounds including gallic acid, catechin, epicatechin, caffeic acid, coumaric, trans-piceid, cis-piceid, trans-resveratrol, cis-resveratrol and quercetin is reported. The UV and fluorescence detector in series provided a high selectivity for the determination of these compounds. Precisions, recoveries and LODs achieved for all the analytes were satisfactory. The proposed method was applied to the determination of these compounds in commercially available red wines.

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“…Cis-form stilbenes can be obtained from trans-form stilbenes through UV-C irradiation (López-Hernández et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Effects of Ultraviolet C Irradiation on Stilbene Biosynthesis in Vitis vinifera L. cv. Cabernet Sauvignon Berry Skins and Calli

Zhan

Huang

2015

SAJEV

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Study of the changes of trans-resveratrol caused by ultraviolet light and determination of trans- and cis-resveratrol in Spanish white wines

Cited by 55 publications

References 39 publications

Development of novel cationic chitosan- and anionic alginate–coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol

Development of novel cationic chitosan- and anionic alginate–coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol

Analysis of non‐anthocyanin phenolic compounds in wine samples using high performance liquid chromatography with ultraviolet and fluorescence detection

Effects of Ultraviolet C Irradiation on Stilbene Biosynthesis in Vitis vinifera L. cv. Cabernet Sauvignon Berry Skins and Calli

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Study of the changes of trans-resveratrol caused by ultraviolet light and determination of trans- and cis-resveratrol in Spanish white wines

Cited by 55 publications

References 39 publications

Development of novel cationic chitosan- and anionic alginate&ndash;coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol

Development of novel cationic chitosan- and anionic alginate&ndash;coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol

Analysis of non‐anthocyanin phenolic compounds in wine samples using high performance liquid chromatography with ultraviolet and fluorescence detection

Effects of Ultraviolet C Irradiation on Stilbene Biosynthesis in Vitis vinifera L. cv. Cabernet Sauvignon Berry Skins and Calli

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Development of novel cationic chitosan- and anionic alginate–coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol

Development of novel cationic chitosan- and anionic alginate–coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol