study of the correlation between vitamin B12, folic acid and ferritin with thyroid hormones in hypothyroidism

Abstract

Background: Thyroid hormones are required for normal development as well as regulating metabolism in the adult. Thyroid gland disorders are the second most abundant endocrinal disorders after diabetes. A decreased thyroid hormone adversely affects erythropoietic system causes anaemia. Aim: The Aim and objective of the study was to compare the vitamin B12, Folate and Ferritin with thyroid hormones in hypothyroidism. Methods: In the present study, total 350 samples were included in which 175 were hypothyroid patients and 175 were normal individuals of age group between 15-65 years. Measurements of serum concentrations of Total T3, Total T4, TSH, Vitamin B12, Folate and Ferritin were done using Chemiluminiscence Immunosorbant Assay. Results: Serum TSH levels were significantly increased in Hypothyroidism as compared to normal individual (7.42±1.75 vs 2.72±1.28, p<0.0001*). The total T3 level was significantly decreased in Hypothyroidism in comparison to normal individual (0.43±0.41 vs 1.30±0.29, p<0.0001*). Similarly, total T4 level was significantly decrease in Hypothyroidism in comparison to normal individual (3.60±1.38 vs. 6.62±1.11, p<0.0001*). Level of Vitamin B12 was significantly decreased in Hypothyroidism in comparison to normal individual (210.45±129.30 vs 483.93±264.74, p<0.0001*). Folate was significantly decreased in Hypothyroidism as compared to normal (2.51±0.99 vs 6.67±0.83, p<0.0001*).

Estimation of LH, FSH, Prolactin, Ferritin and Vitamin B12 of Hypothyroid Women in Kirkuk City/Iraq

“…The results as shown in Table 2 agreed with [31] and [36] whom recorded an increasment in prolactin levels in hypothyroid patient compared to control group, this increasment is due to high levels of TRH in hypothyroid stimulates the lactotrophs in pituaitry gland which leads to rise its level in the blood [37 Whin we studied the level of vitamin B12 the results shows a significant decrease in Vitamin B12 level (P ≤ 0.027) in hypothyroid patients compared to control group as shown in Table 3. This findings agreed with [38] and [39] whom recorded a decreasement in Vitamin B12 levels in hypothyroid patients compared to control group and there is no results disagreed with this findings, the cause of Vitamin B12 deficiency in hypothyroidisim is due to the malabsorption of Vitamin B12 in hypothyroid patient [40], Jaya and his assistant found that 1/3 of hypothyroid patient had antibody against parietal cell that secreted intrinsic factor which help to well absorb the Vitamin B12 [41].…”

Evaluation of Vitamin B12, Folic Acid in Hypothyroidism Patients

“…[20] Level of Vitamin B12 was significantly decreased in Hypothyroidism in comparison to normal individual. Folate was significantly decreased in Hypothyroidism as compared to normal [13].…”

“…Low serum ferritin is one of the most common reasons of thyroid dysfunction. [12,13] The prevalence of vitamin B12 insufficiency rises with age. Patients with vitamin B12 insufficiency with hypothyroidism typically experience fatigue, weakness, poor memory retention, itching, and loss of feeling.…”

Different novel biomarkers involved in diagnosing hypothyroidism

“…If iron is tested then total iron binding capacity is checked with lower hemoglobin in the blood [82]. Though the lower level of iron is directly related with anemia and ferritin as it is its storage form, mostly, iron test is enough for confirming deficiency as a complication [83,84]. The TIBC test is as same as iron and ferritin so the normal range in this test is 240 to 450mcg/dL [85].…”