Study of the effect of plasticizer on the structure and surface characteristics of ethylcellulose free films with FT-IR spectroscopy

Hegyesi, Diána; Sovány, Tamás; Berkesi, Ottó; Pintye‐Hódi, Klára; Regdon, Géza

doi:10.1016/j.microc.2013.02.005

Cited by 16 publications

(6 citation statements)

References 16 publications

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“…At last, it must be mentioned other cellulosic derivatives such as cellulose nitrate that can be plasticized by alkyd resins, phthalates, carboxymethylcellulose, sorbitan monopalmitate, and ethyl cellulose by ESBO or triethyl citrate …”

Section: Plasticized Polymersmentioning

confidence: 99%

Petro‐based and bio‐based plasticizers: Chemical structures to plasticizing properties

Bocqué

Voirin

Lapinte

et al. 2015

J. Polym. Sci. Part A: Polym. Chem.

349

322

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Polymeric materials, in particular PVC, can find various industrial utilizations thanks to the use of plasticizers added during their processing. The most famous applications include wires and cables, coatings, flooring, paintings, packaging… After some generalities concerning plasticization theories and the description of plasticized petro‐ and bio‐based polymers, this review details the well‐known different petro‐based plasticizers and more particularly phthalates which represent the most important category of PVC plasticizers. Owing to migration problems, impact on the human health and the environment, alternative candidates have been developed by researchers. Renewable resources and their wastes offer a large platform for the design of bio‐based plasticizers using polysaccharidic or lipidic structures. In an in‐depth analysis, the bio‐based plasticizer structures, their groups and substituents (ester groups, alkyl chains, aromatic rings…) are gathered and examined in order to be able to predict their plasticizing efficiency and design new molecular and macromolecular plasticizers from natural resources. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 11–33

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Section: Plasticized Polymersmentioning

confidence: 99%

Petro‐based and bio‐based plasticizers: Chemical structures to plasticizing properties

Bocqué

Voirin

Lapinte

et al. 2015

J. Polym. Sci. Part A: Polym. Chem.

349

322

View full text Add to dashboard Cite

show abstract

“…The most expressive peak, at 1,750 cm −1 , belongs to the vibrations C=O. The other characteristic bands of the plasticizer coincide with the ethyl cellulose absorption regions, with the OH grouping band and C-O-C vibration of the ester group (Hegyesi et al, 2013).…”

Section: Infrared Spectroscopy (Ftir)mentioning

confidence: 80%

Application of zein and chitosan in the development of a colon-specific delivery system

Zara¹,

Stival²,

Shioji³

et al. 2020

J Appl Pharm Sci

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Drug release in the colon is a therapeutic alternative for pathologies that affect this organ, for absorption of peptide drugs and proteins, and in chronopharmacotherapy. Systems for this purpose should be formulated considering the obstacles of the gastrointestinal tract. Strategies used consider characteristics such as pH, enzymatic activity, microflora, and transit time. This work aims to present a system to deliver drugs directly to the colon using the natural polymers zein and chitosan. The biopolymers were prepared with the objective of obtaining effective polymer dispersions to be applied in the coating of tablets and evaluated for in vitro dissolution profile. The polymer films obtained by casting were characterized by Fourier-transform infrared spectroscopy, thermal analysis, mechanical analysis, and water vapor transmission. The results obtained demonstrate that zein can be used as a sealing coat to separate incompatible materials and as a barrier against moisture. They also show that chitosan is specifically degraded by the colonic flora and, when associated with ethyl cellulose, can be applied as support for the colon-specific delivery.

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“…FT‐IR spectroscopy is a suitable method for investigating interactions between pharmaceutical materials and polymers 33. For FT‐IR determination, the attenuated total reflection (ATR) method was chosen because sample preparation such as particle size reduction or KBr tableting is not required, which would expose the samples to further physical stress.…”

Section: Resultsmentioning

confidence: 99%

Effect of Co‐Grinding on Crystallinity of Clopidogrel Bisulfate

2014

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A high energy input during pharmaceutical formulation is capable of decreasing the crystallinity of compounds in the product. The presence of the amorphous form can cause serious problems at any stage of the formulation. Crystallinity changes of a model powder mixture containing clopidogrel bisulfate (CLP) and a colloidal silicon dioxide as additive were investigated during a long-time co-grinding process. The crystallinity of CLP was reduced sigmoidally by co-grinding with longer co-grinding time. X-ray powder diffraction and differential scanning calorimetry examinations confirmed that the product had become totally amorphous after four hours of grinding. Thermogravimetric results proved that no major mass reduction happened and FT-IR changes referred to formulation of a secondary bond between the components.

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Study of the effect of plasticizer on the structure and surface characteristics of ethylcellulose free films with FT-IR spectroscopy

Cited by 16 publications

References 16 publications

Petro‐based and bio‐based plasticizers: Chemical structures to plasticizing properties

Petro‐based and bio‐based plasticizers: Chemical structures to plasticizing properties

Application of zein and chitosan in the development of a colon-specific delivery system

Effect of Co‐Grinding on Crystallinity of Clopidogrel Bisulfate

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