Study of Thrombophilia in Recurrent Pregnancy Loss

Hansda, Jayasree; Roychowdhury, Joydeb

doi:10.1007/s13224-012-0197-x

Cited by 15 publications

(9 citation statements)

References 17 publications

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“…in Indian patients with RLP ( P = 0.000). [ 44 ] Furthermore, Jyotsna et al . described a significant risk of RPL in pregnant Indian women with thrombophilias.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and role of antithrombin III, protein C and protein S deficiencies and activated protein C resistance in Kosovo women with recurrent pregnancy loss during the first trimester of pregnancy

et al. 2015

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CONTEXT:Several studies have reported that thrombophilia is responsible for recurrent pregnancy loss (RPL).AIMS:The aim of this study was to evaluate the prevalence and role of inherited thrombophilia in early pregnancy loss, specifically in the first trimester.MATERIALS AND METHODS:A total of 104 women (patients) with a history of two or more miscarriages during the first trimester of pregnancy and 110 women (controls) who had experienced two or more births without a miscarriage were included in this study. In both groups, we determined the biological activities of antithrombin III (ATIII) and protein C (PC) using the chromogenic method and the biological activity of protein S (PS) and the activated protein C resistance (APCR) were examined using a clotting method.RESULTS:In the patient group, deficiencies of ATIII, PC, and PS were detected in 3 (2.88%), 4 (3.85%), and 6 (5.77%) cases, respectively. In the control group, ATIII (0%) deficiencies were not detected, and deficiencies for PC (0.9%) and PS (0.9%) were each detected in 1 patient. APCR was detected in 9 patients (8.65%) and 4 control subjects (3.63%).CONCLUSION:Based on our results, we can conclude that thrombophilia is a causal factor for miscarriages in the first trimester of pregnancy, although there are the conflicting data in the literature.

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“…in Indian patients with RLP ( P = 0.000). [ 44 ] Furthermore, Jyotsna et al . described a significant risk of RPL in pregnant Indian women with thrombophilias.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and role of antithrombin III, protein C and protein S deficiencies and activated protein C resistance in Kosovo women with recurrent pregnancy loss during the first trimester of pregnancy

et al. 2015

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“…It is this hypercoaguable condition that paves way to thrombotic events more often in pregnant population than in general population resulting in adverse outcomes like abortions or recurrent abortions, intraurine growth restriction, intrauterine fetal demise, placental abruption and preeclampsia. [1][2][3][4][5][6][7][8][9][10][11][12][13] Hence, the evaluation and management of thrombophilia is imperative in women who have history of fetal loss/losses or adverse pregnancy outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…The thrombotic events are not only restricted to venous thromboembolism but also can cause fetal loss (abortions or recurrent abortions and fetal demise), placental abruption, intrauterine growth restriction and severe preeclampsia. [1][2][3][4][5][6][7][8][9][10][11][12][13] In the recent years various studies have evaluated the role of administering thromboprophylaxis to patients with previous history of adverse obstetric outcomes who have tested positive for inherited and acquired thrombophilia. 11,[14][15][16][17] This study adds to the existing data base discerning the role of thromboprophylaxis with heparin and ecosprin in patients with thrombophilia in pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Role of low dose ecosprin and heparin in achieving live births in pregnancy with thrombophilia

Asthana

Sodhi²,

Kumar³

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Thrombophilia is a disorder of haemostatic system that results in increased tendency of thrombus formation in both venous and arterial vascular system. The thrombotic events are not only restricted to venous thromboembolism but also can cause fetal loss (abortions or recurrent abortions and fetal demise), placental abruption, intrauterine growth restriction and severe pre-eclampsia. This study evaluates the role of administering thromboprophylaxis with heparin and ecosprin to patients with thrombophilia in pregnancy with previous history of adverse obstetric outcomes.Methods: This prospective study was conducted in 60 patients diagnosed with thrombophilia during pregnancy. The objective of the study was to determine the role of administering low dose ecosprin and heparin as thromboprophylaxis in achieving live births in these patients with thrombophilia. All patients included in this study were prophylactically administered low dose ecosprin with either unfractionated heparin (5000 IU s.c, BD) or low molecular weight heparin (40 mg s.c, OD) during pregnancy. Patients were followed up in the antenatal period and the obstetric outcome noted. Comparisons were made between the obstetric outcomes of these patients receiving the aforesaid thromboprophylaxis with those of previous untreated pregnancies during which no ecosprin or heparin had been administered. The data obtained were subjected to statistical analysis using Students ‘t’ test and Chi square analysis. P value <0.05 was considered statistically significant.Results: Fifty nine of the sixty patients with thrombophilia and previous adverse pregnancy outcome who received prophylaxis with ecosprin and heparin during the present pregnancy had live births (98.33%; p <0.0001). Fifty-eight (96.66%) of these patients progressed to term delivery and one (1.67%) pregnancy resulted in a pre-term birth.Conclusions: Present study reveals that prophylaxis with low dose ecosprin and heparin administered to patients with thrombophilia (acquired or inherited) with history of previous adverse obstetric outcome resulted in a positive outcome in terms of a significantly higher number of live births. However, larger studies are needed to further elaborate on the role of thromboprophylaxis in pregnancies with inherited thrombophilia.

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“…Among this PS deficiency had the strongest association [ 4 6 7 8 ]. Among Indian literature Vora et al [ 9 ] had 17.8% RPL patients with PS deficiency while Hansda and Roychowdhury [ 15 ] had 50% RPL patients. In our data, we had 2.7% of patients with PS deficiency.…”

Section: Discussionmentioning

confidence: 99%

Inherited thrombophilia profile in patients with recurrent miscarriages: Experience from a tertiary care center in north India

et al. 2015

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The cause of recurrent miscarriage (RM) remains unexplained in approximately 30% to 50% cases. The association of inherited thrombotic factors and RM patients has not been documented from the northern part of India. A total of 40 patients had been investigated for inherited thrombophilia workup (protein C, protein S [PS], antithrombin III, and factor V Leiden [FVL] mutation) over a period of 10 years (2005 to 2014). RM patients were divided in to three groups. Group I (only 1st trimester loss), group II (only 2nd and 3rd trimester), and group III (mixed). Each group comprised of the following numbers of patients respectively: I, 24; II, 2; III, 14. Heterozygous FVL mutation was found in 10% (4/40) cases. PS deficiency was detected in 2.7% (1/37) cases. In the present study FVL and PS were seems to be associated with a subset of patients however further studies with larger numbers of patients are recommended for better evaluation.

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Study of Thrombophilia in Recurrent Pregnancy Loss

Cited by 15 publications

References 17 publications

Prevalence and role of antithrombin III, protein C and protein S deficiencies and activated protein C resistance in Kosovo women with recurrent pregnancy loss during the first trimester of pregnancy

Prevalence and role of antithrombin III, protein C and protein S deficiencies and activated protein C resistance in Kosovo women with recurrent pregnancy loss during the first trimester of pregnancy

Role of low dose ecosprin and heparin in achieving live births in pregnancy with thrombophilia

Inherited thrombophilia profile in patients with recurrent miscarriages: Experience from a tertiary care center in north India

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