Study on the enhancement of Ru(bpy)32+ electrochemiluminescence by nanogold and its application for pentoxyverine detection

Liu, Yingju; Pan, Wen; Liu, Qian; Yao, Shouzhuo

doi:10.1002/elps.200500391

Cited by 31 publications

(21 citation statements)

References 33 publications

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“…Therefore, the quantity of ${\rm{Ru(bpy)}}_3^{2 + }$ can be greatly enhanced while ${\rm{Ru(bpy)}}_3^{3 + }$ decreases, which causes a dramatic increase in oxidation current and a decrease in the reduction current. According to the precious reports 9, 24, 31, the mechanism can be described as follows: …”

Section: Resultsmentioning

confidence: 99%

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Generation of gold nanostructures at the surface of platinum electrode by electrodeposition for ECL detection for CE

et al. 2010

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In this paper, we report a sensitive method for ECL detection for CE based on generation of gold nanostructures at the surface of Pt electrode by electrodeposition. Difenidol hydrochloride was used as a model analyte. With the increase of electrodeposition amount, the morphology of gold nanostructures changed from discrete nanoflowers to dense nanoparticle array. Interestingly, the variation of deposition amount also greatly affected the ECL intensity of difenidol. The ECL intensity increased remarkably with deposition amount and reached the maximum value at the deposition amount of 7.0 Â 10 À8 C; further increasing the deposition amount, however, caused the ECL intensity to decrease. Other conditions, including applied potential, injection time and voltage, buffer pH, were also optimized in detail. Under the optimized conditions, the linear response range of difenidol is from 1.0 Â 10 À8 to 5.0 Â 10 À5 M, and the detection limit was 4.0 Â 10 À9 M (S/N 5 3). The RSDs of ECL intensity and migration time were 2.0 and 1.6%, respectively (n 5 5, at 7.5 mM difenidol). Compared with using bare electrode, the detection sensitivity was significantly improved by ca. two orders of magnitude. Notably, the nanogold was prepared at the surface of electrode and no nanogold was added to the electrophoretic buffer or detection cell, thus causing no interference to the separation. Finally, the proposed method was successfully applied to the analysis of difenidol in tablets and urine samples. With high sensitivity and good reproducibility, this method provides a promising platform for the determination of pharmaceuticals that have a tertiary amine group such as difenidol. 3 -based ECL detection offers lower background noise, higher detection sensitivity and has been adopted widely for detection of various analytes [4][5][6][7][8][9]. Coupling ECL detection with CE has also been widely investigated, and a variety of methods have been developed to enhance the sensitivity of ECL detection [10][11][12]. KeywordsMetal nanoparticles have attracted much interest in analytical chemistry because of their easy preparation and relatively large surface area, size-controllability and unusual chemical properties [13][14][15]. Specifically, Pt and Au nanoparticles (Pt/AuNPs) have shown some fascinating properties in modifying electrode [16][17][18][19]. They can increase the electrode surface area, promote electron transfer and thus enhance the detection sensitivity [20,21]

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Section: Resultsmentioning

confidence: 99%

“…reported the use of AuNPs to enhance the ECL detection of pentoxyverine in CE 24. The AuNPs were added into the detection cell, and were thought to be able to increase the photon efficiency and the rate of the ECL reaction, and thereby had a positive effect on ECL intensity 24. Recently, a similar strategy was also used by Wang et al .…”

Section: Introductionmentioning

confidence: 99%

Generation of gold nanostructures at the surface of platinum electrode by electrodeposition for ECL detection for CE

et al. 2010

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“…When the pH was higher than these values, the ECL intensity decreased slightly. The possible reason was considered as the reduced availability of

{Ru (bpy)}_{3}^{2 +}

at high pH due to the competitive reaction of OH − which consumed considerable

{Ru (bpy)}_{3}^{3 +}

. Considering a good separation result and a high ECL intensity, the optimal pH was 8.5.…”

Section: Resultsmentioning

confidence: 99%

Simultaneous determination of lappaconitine hydrobromide and isopropiram fumarate in rabbit plasma by capillary electrophoresis with electrochemiluminescence detection

Zhou

Liu

et al. 2012

Electrophoresis

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A CE electrochemiluminescence (CE-ECL) method for simultaneous determination of lappaconitine hydrobromide (LH) and isopropiram fumarate (IF) has been first established, with a chemically modified platinum electrode by europium (III)-doped Prussian blue analogue film as a working electrode. The conditions for CE separation and ECL detection are discussed and optimized in detail. It has been proved that 20 mmol/L phosphate buffer (pH 8.5) containing 5% (v/v) ACN and 0.17 mol/L SDS could achieve the most favorable resolution, and the high sensitivity of detection was obtained by maintaining the detection potential at 1.23 V. Under optimized conditions, a baseline separation for the two analytes was achieved within 6 min, and the standard curves were linear in the range of 1.0×10(-7) ~ 5.0 × 10(-5) g/mL for LH and 4.0 × 10(-8) ~ 1.0 × 10(-5) g/mL for IF with the detection limits (3σ) of 6.6 × 10(-8) g/mL for LH and 3.7 × 10(-8) g/mL for IF, respectively. The precisions of intra- and interday measurements for LH and IF were less than 4.21 and 2.61%, respectively. The applicability of the proposed method was illustrated in the determination of LH and IF in rabbit plasma with recoveries between 95.6 and 103.0%.

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“…This system, which used the ECL cell previously developed [41], involves a great progress in CE-ECL in the last few years and has been applied to the determination of alkaloids in plants [47], dioxopromethazine in urine and plasma [48], proline and hydroxyproline in urine [49], pentoxyverine [50] or roxithromycin [51], both methods using gold nanoparticles (AuNPs) to enhance the ECL intensity, bupivacaine in plasma [52], norfloxacine in urine without sample treatment [53], bisoprolol in tablets and urine [54], etc. (Table 1).…”

Section: Luminol -Pharmaceutical and Clinical Applicationsmentioning

confidence: 99%

Advances and analytical applications in chemiluminescence coupled to capillary electrophoresis

2010

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Advances and analytical applications in chemiluminescence coupled to capillary electrophoresisThe present review presents the state of the art of the developments, key strategies and analytical applications of chemiluminescence detection coupled to CE (CE-CL). Different parts considering the most common CL systems have been included, such as the tris(2,2 0 -bipyridine)ruthenium(II) system, the luminol and derivatives reaction, the peroxyoxalate CL or direct oxidations. New advances in homemade configurations and applications in different fields such as clinical, pharmaceutical, environmental and food analysis have been included. The focus is on studies which appeared from 2000 to the end of 2009.

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Study on the enhancement of Ru(bpy)32+ electrochemiluminescence by nanogold and its application for pentoxyverine detection

Cited by 31 publications

References 33 publications

Generation of gold nanostructures at the surface of platinum electrode by electrodeposition for ECL detection for CE

Generation of gold nanostructures at the surface of platinum electrode by electrodeposition for ECL detection for CE

Simultaneous determination of lappaconitine hydrobromide and isopropiram fumarate in rabbit plasma by capillary electrophoresis with electrochemiluminescence detection

Advances and analytical applications in chemiluminescence coupled to capillary electrophoresis

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