Sulforaphane attenuates dextran sodium sulphate induced intestinal inflammation via IL-10/STAT3 signaling mediated macrophage phenotype switching

Sun, Yuyang; Tang, Jiqing; Cui, Li; Liu, Jun; Liu, Haijie

doi:10.1016/j.fshw.2021.07.014

Cited by 19 publications

(18 citation statements)

References 51 publications

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“…SFN has been tested in various disease models for its preventive effects on inflammation, liver injury and steatosis [ 9 , 10 ]. Previous work has shown that sulforaphane alleviated colitis severity in mice induced by DSS, supported by suppressed inflammatory cytokine expression, enhanced M2 macrophage polarization, and increased probiotic Butyricicoccus abundance [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Broccoli-Derived Glucoraphanin Activates AMPK/PGC1α/NRF2 Pathway and Ameliorates Dextran-Sulphate-Sodium-Induced Colitis in Mice

Tian

Sun

et al. 2022

Antioxidants

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As the prevalence of inflammatory bowel diseases (IBD) rises, the etiology of IBD draws increasing attention. Glucoraphanin (GRP), enriched in cruciferous vegetables, is a precursor of sulforaphane, known to have anti-inflammatory and antioxidative effects. We hypothesized that dietary GRP supplementation can prevent mitochondrial dysfunction and oxidative stress in an acute colitis mouse model induced by dextran sulfate sodium (DSS). Eight-week-old mice were fed a regular rodent diet either supplemented with or without GRP. After 4 weeks of dietary treatments, half of the mice within each dietary group were subjected to 2.5% DSS treatment to induce colitis. Dietary GRP decreased DSS-induced body weight loss, disease activity index, and colon shortening. Glucoraphanin supplementation protected the colonic histological structure, suppressed inflammatory cytokines, interleukin (IL)-1β, IL-18, and tumor necrosis factor-α (TNF-α), and reduced macrophage infiltration in colonic tissues. Consistently, dietary GRP activated AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1α, and nuclear factor erythroid 2-related factor 2 (NRF2) pathways in the colonic tissues of DSS-treated mice, which was associated with increased mitochondrial DNA and decreased content of the oxidative product 8-hydroxydeoxyguanosine (8-OHDG), a nucleotide oxidative product of DNA. In conclusion, dietary GRP attenuated mitochondrial dysfunction, inflammatory response, and oxidative stress induced by DSS, suggesting that dietary GRP provides a dietary strategy to alleviate IBD symptoms.

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Section: Introductionmentioning

confidence: 99%

Broccoli-Derived Glucoraphanin Activates AMPK/PGC1α/NRF2 Pathway and Ameliorates Dextran-Sulphate-Sodium-Induced Colitis in Mice

Tian

Sun

et al. 2022

Antioxidants

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“…In the present study, 5-demethylnobiletin, sinensetin, tetramethyl-O-scutellarin, and nobiletin were generally effective in promoting an increase in TGF-β ( Figure 4C ). It has also been established that the phenotype of macrophages undergoes a transition from M1 to M2 in response to the up-regulated expression of IL-10 ( 40 ). We found that the individual citrus PMFs had a significant promotive effect on IL-10, with tangeretin being observed to strongest capacity in this regard ( Figure 4D ).…”

Section: Resultsmentioning

confidence: 99%

“…We found that the individual citrus PMFs had a significant promotive effect on IL-10, with tangeretin being observed to strongest capacity in this regard ( Figure 4D ). On the basis of the findings with respect to IL-10, we speculated that IL-10/STAT3 signal-mediated macrophage phenotypic transition is one of the pathways via which PMFs contribute to an alleviation of LPS-induced inflammation ( 40 ). In summary, on the basis of comparative analysis of the structures of the five assessed PMF monomers, the difference in the mechanisms of action could be associated with the number and position of methoxy groups and the presence of hydroxyl groups.…”

Section: Resultsmentioning

confidence: 99%

Comparative effects of five polymethoxyflavones purified from Citrus tangerina on inflammation and cancer

Chen

Gu²,

Tan³

et al. 2022

Front. Nutr.

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Although the Citrus tangerina cultivar “Dahongpao” (CTD) has been established as a rich source of polymethoxyflavones (PMFs) with anti-inflammatory and anti-cancer properties, their individual effects on cellular signaling remain to be elucidated. In this study, five major PMFs from the peel of CTD were isolated, including sinensetin, tetramethyl-O-scutellarin (5,6,7,4′-tetramethoxyflavone), nobiletin (5,6,7,8,3′, 4′-hexamethoxyflavone), tangeretin (5,6,7,8,4′-pentamethoxyflavone), and 5-demethylnobiletin (5-OH-6,7,8,3′,4′-pentamethoxyflavone). These PMFs were found to significantly (p < 0.05) inhibit the production of NO and biomarkers of chronic inflammation (TNF-α and IL-6). Additionally, they effectively suppressed mRNA biomarkers of acute inflammation (Cox-2 and iNOS), and to varying degrees promoted the activation of anti-inflammatory cytokines (IL-4, IL-13, TNF-β, and IL-10). Among the five PMFs, tangeretin was found to have a considerable anti-proliferative effect on tumor cell lines (PC-3 and DU145) and synergistically enhanced the cytotoxicity of mitoxantrone, partially via activation of the PTEN/AKT pathway. The findings of this study provide valuable insights into the activity of different PMF monomers and advance the understanding of the roles of PMFs in promoting apoptotic and anti-cancer effects.

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“…EVOO has in vitro proven anti-inflammation effects of polyphenols on macrophages [ 36 , 37 ], including the reduction in NO release and iNOS expression. Fish oil in human studies represents the inhibition of inflammation-related genes expression in macrophages [ 38 ] and fresh vegetables, especially cruciferous, are pointed out by outstanding anti-inflammatory properties through biological-active compounds, which promote the M2 (anti-inflammatory) type of macrophage proliferation [ 39 ]. Nowadays, the MTD is one of the diet patterns with evidence-based positive effects on population health and life-expectancy.…”

Section: The Role Of Diet Patterns and Food Groupsmentioning

confidence: 99%

“…Sulforaphane (from cruciferous vegetables) is another phytochemical capable of reducing the pro-inflammation and tumor-associated macrophage proliferation, including the affection of cytokines genes expression [ 39 , 92 ]. A similar anti-tumor effect on tumor-associated macrophages is described for another plant-based biologically active substance—schizandrin [ 93 ].…”

Section: The Role Of Micronutrients and Biologically Active Compoundsmentioning

confidence: 99%

The Role of Diet in Regulation of Macrophages Functioning

et al. 2022

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The great importance of diet for health and high life-expectancy is established. The impact of nutrients on immune system is a point of growing research interest. Recent studies have found pro- and anti-inflammatory properties of some diet patterns and nutrients that can be used from the bench to the bedside for chronic low-grade inflammatory status correction. In this regard, the assessment of potential effects of nutrition on macrophage differentiation, proliferation, and functioning in health and disease is highly demanded. In this review, we present current data on the effects of nutrients on the macrophage functioning.

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Sulforaphane attenuates dextran sodium sulphate induced intestinal inflammation via IL-10/STAT3 signaling mediated macrophage phenotype switching

Cited by 19 publications

References 51 publications

Broccoli-Derived Glucoraphanin Activates AMPK/PGC1α/NRF2 Pathway and Ameliorates Dextran-Sulphate-Sodium-Induced Colitis in Mice

Broccoli-Derived Glucoraphanin Activates AMPK/PGC1α/NRF2 Pathway and Ameliorates Dextran-Sulphate-Sodium-Induced Colitis in Mice

Comparative effects of five polymethoxyflavones purified from Citrus tangerina on inflammation and cancer

The Role of Diet in Regulation of Macrophages Functioning

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