Sunscreens block cutaneous vitamin D production with only a minimal effect on circulating 25-hydroxyvitamin D

Libon, Florence; Courtois, Justine; Goff, Caroline Le; Lukas, Pierre; Fabregat-Cabello, Neus; Seidel, Laurence; Cavalier, Étienne; Nikkels, Arjen F.

doi:10.1007/s11657-017-0361-0

Cited by 34 publications

(37 citation statements)

References 33 publications

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“…This variable was not a determining factor in the dosage of vitamin D levels for both groups, similar to the results of the study by Niruban et al with infants with RW. Because of their photo absorbent property, the protectors significantly reduce or even block the absorption of UVB radiation through the skin …”

Section: Discussioncontrasting

confidence: 47%

Lung disease and vitamin D levels in cystic fibrosis infants and preschoolers

Oliveira¹,

Matsunaga²,

Rodrigues³

et al. 2019

Pediatric Pulmonology

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Introduction: Vitamin D acts on the immune system and lung response. Patients with cystic fibrosis (CF) may be deficient in this vitamin. The aims of the study were to evaluate vitamin D levels and severity of lung disease in infants and preschoolers diagnosed with CF, and to compare them to a group of children without pancreatic insufficiency (PI). Methods: Patients with CF up to 4 years old were included, and compared to an agematched group of children without diagnosis of CF. CF group had medical records and High Resolution Thorax Computed Tomography (HRCCT) evaluated in order to verify the severity of lung disease. Information on demographic data, sun exposure habits, supplemental vitamin D therapy, and on the season at the time of vitamin D sampling were collected for both groups.Results: This study included 45 patients in the CF group and 102 in the non-CF group, with no differences in age (P = 0.327) between them. There was no association between vitamin D levels and markers of lung disease in the CF group. The non-CF group had lower daily sun exposure (P = 0.034), and lower supplementation than the CF group (P < 0.001). Supplementation and seasonality were the determinant variables for vitamin D levels, which were lower for non-supplemented children and for assessments during fall/winter. Conclusion:There was no association between lung disease severity and vitamin D levels in CF group. Supplementation and seasonality were associated to higher vitamin levels. K E Y W O R D Scystic fibrosis, infants and preschoolers, lung disease, neonatal screening, vitamin D

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Section: Discussioncontrasting

confidence: 47%

Lung disease and vitamin D levels in cystic fibrosis infants and preschoolers

Oliveira¹,

Matsunaga²,

Rodrigues³

et al. 2019

Pediatric Pulmonology

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“…In general, the UVR dose of these studies is low, e.g. this was 0·8 MED (estimated to be ~3 SED in skin type III volunteers) with SPF 50 at 2 mg cm −2 in the study of Libon et al . Taking the SPF at face value means the dose through the sunscreen is 3/50 = 0·06 SED.…”

Section: Conclusion and Recommendations From Panel Discussionmentioning

confidence: 97%

Sunscreen photoprotection and vitamin D status

Passeron

Bouillon

Callender³

et al. 2019

Br J Dermatol

144

108

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“…Clothes that cover most of the body parts for cultural reasons, and frequent application of sunscreen creams on skin in females could be the reasons of lower summer vitamin D levels in female patients with PID. [22,23] In the study group, number of the patients with low serum vitamin D levels who had infections in winter was higher than those in summer. Although there are numerous studies showing the association between vitamin D levels and infection, reports demonstrating the effects of seasonal vitamin D variations on infections in PID patients are limited.…”

Section: Discussionmentioning

confidence: 90%

The Association Between Vitamin D Levels and Infections in Patients with Primary Immunodeficiency

Çetinkaya¹,

Ayvaz²,

Cüzdanci³

et al. 2019

Turk J Immunol

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Introduction: Vitamin D is a hormone responsible in the regulation of immune response. This study was designed to assess the relationship of vitamin D deficiency on the development of infections in patients with primary immunodeficiency (PID). Materials and Methods:A total of 39 patients (M/F: 23/16) and 39 age-and sex-matched healthy controls (M/F: 23/16) were enrolled in the study. We measured the frequency of infections and serum vitamin D levels in winter and summer seasons. Results:The median age of the patient and control groups were 15.0 (Interquartile range: 7.5-26.0) years and 14.0 (9.0-25.0) years, respectively (p=0.810). Winter and summer vitamin D levels were similar both in patient and control groups (p=0.492 for winter, p=0.503 for summer). Number of the patients with low serum vitamin D levels and with infections were higher in winter than in summer. Autoimmune and inflammatory diseases (AID) were predominantly observed in patients with low winter vitamin D levels and in common variable immunodeficiency (CVID) group. Patients with CVID had lower serum vitamin D levels both in summer (p=0.048) and in winter (p=0.008). Conclusions:In this study, we showed the seasonal variation of serum vitamin D in patients with PID. There was also increased frequency of CVID and AID in those patients with low vitamin D levels. In addition, vitamin D might be given in winter to the patients with PID to take infections and autoimmune disorders under control. ÖzGiriş: D vitamini, bağışıklık cevaplarının düzenlenmesinden sorumlu bir hormondur. Bu çalışma, D vitamini eksikliğinin primer immün yetersizliği olan hastalarda (PİY) enfeksiyon gelişimi ile ilişkisini değerlendirmek için tasarlanmıştır.Gereç ve Yöntemler: Çalışmaya toplam 39 hasta (E / K: 23/16) ve 39 yaş ve cinsiyet uyumlu sağlıklı kontrol grubu (E / K: 23/16) alındı. Kış ve yaz aylarında enfeksiyon sıklığı ve serum D vitamini düzeyleri saptandı.Bulgular: Hasta ve kontrol grubunun ortanca yaşı 15.0 (çeyrekler arası aralık: 7.5-26.0) ve 14.0 (9.0-25.0) idi (p = 0.810). Kış ve yaz D vitaminleri hem hasta hem de kontrol grubunda benzerdi (p=0.492 kış için, p0.503 yaz için). Serum D vitamini düzeyi düşük ve enfeksiyonu olan hastaların sayısı kışın yaz aylarında olduğundan daha fazla idi. Otoimmün ve enflamatuvar hastalıklar (OIH) ağırlıklı olarak, düşük kış D vitamini düzeyi olan hastalarda ve yaygın değişken immün yetersizlikli hastalık (YDİY) grubunda gözlemlendi. YDİY tanılı hastaların hem yaz (p=0.048) hem de kış (p=0.008) D vitamini düzeyleri düşüktü.Sonuç: Bu çalışmada PİY tanılı hastalarda serum D vitamini düzeylerinin mevsimsel değişimi gösterilmiştir. Düşük D vitamini düzeyleri olan hastalarda ayrıca YDİY ve OİH sıklığı artmıştır. Ek olarak, D vitamini, enfeksiyonları ve otoimmün hastalıkları kontrol altına almak için PID'li hastalara kışın verilebilir.Anahtar Kelimeler: Otoimmün hastalıklar, enfeksiyon, primer immün yetersizlik, D vitamini eksikliği

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Sunscreens block cutaneous vitamin D production with only a minimal effect on circulating 25-hydroxyvitamin D

Cited by 34 publications

References 33 publications

Lung disease and vitamin D levels in cystic fibrosis infants and preschoolers

Lung disease and vitamin D levels in cystic fibrosis infants and preschoolers

Sunscreen photoprotection and vitamin D status

The Association Between Vitamin D Levels and Infections in Patients with Primary Immunodeficiency

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