Supramolecular Photosensitizers with Enhanced Antibacterial Efficiency

Abstract

Photodynamic therapy: A novel supramolecular photosensitizer is efficiently fabricated based on a strong host–guest interaction, which shows an enhanced singlet oxygen generation ability of the porphyrin units and has thus a greatly improved antibacterial efficiency (see picture). The supramolecular photosensitizer is an adaptive system with switchable photophysical properties.

Photolysis of an Amphiphilic Assembly by Calixarene-Induced Aggregation

“…Interestingly, the photodecomposition of aggregated AnPy was significantly promoted, while it was reported that the fluorescence of photosensitizers could be generally self-quenched after aggregation, 16 resulting in greatly reduced ability for singlet oxygen generation and lower photoreactivity. 17 The supramolecular assembly exhibited efficient photolysis with visible light in the presence of exogenous photosensitizers. To the best of our knowledge, such a photolyzable system promoted by supramolecular aggregation has not been reported to date.…”

Regulation of oxidative stress inside living cells through polythiophene derivatives

“…Besides, CPs can harvest the energy of light efficiently and sensitize the surrounding oxygen molecules to generate ROS, thus, CPs are employed to inhibit the proliferation of cancer cells and used as antimicrobial [27][28][29]. Polythiophene modified with dihydropyridine (PTDHP) was reported owning ROS-scavenging ability via oxidizing dihydropyridine into pyridine [30].…”

Photocontrollable release and enhancement of photodynamic therapy based on host–guest supramolecular amphiphiles

“…[1][2][3][4][5] PDT involves the use of a photosensitizer (PS), an appropriate light source and the coexistence of tissue oxygen. [13][14][15][16][17][18][19][20] The light irradiated PSs (with different doses, times and locations) could make the PDT more controllable and minimally invasive. [13][14][15][16][17][18][19][20] The light irradiated PSs (with different doses, times and locations) could make the PDT more controllable and minimally invasive.…”