Surface enhanced Raman scattering for multiplexed detection

Dougan, Jennifer A.; Faulds, Karen

doi:10.1039/c2an15979a

Cited by 113 publications

(113 citation statements)

References 62 publications

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“…SERS is a powerful and reliable analytical tool for the ultra-sensitive detection of analytes even at the single molecule level. 562,563 SERS is attributed to an electromagnetic mechanism (EM) based on surface plasmon resonance (SPR) and/or a chemical mechanism (CM) based on charge transfer. 564 SERS substrates often suffer from a lack of adsorption of molecules.…”

Section: Surface-enhanced Raman Scattering Substratesmentioning

confidence: 99%

Graphene based metal and metal oxide nanocomposites: synthesis, properties and their applications

et al. 2015

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Section: Surface-enhanced Raman Scattering Substratesmentioning

confidence: 99%

Graphene based metal and metal oxide nanocomposites: synthesis, properties and their applications

et al. 2015

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“…Therefore, a single substrate can work for almost "all" available excitation wavelengths, which is particularly useful for sensing a broad spectrum of chemicals on the same chip. [29][30][31]35 ] In addition, it can serve as a universal substrate for surfaceenhanced resonant Raman spectroscopy (SERRS) [ 30,31,36,37 ] by providing resonant excitation enhancement to resonant molecules over a broad band. For instance, ref.…”

Section: Introductionmentioning

confidence: 99%

“…[22][23][24][25][26][27][28] When one wants to identify anonymous trace molecules or mixed samples, multiple excitation wavelengths will be required. [29][30][31] In this case, different substrates have to be used for different wavelength excitation, which consumes more biological/chemical materials, substrates, and measurement time. This is an obvious disadvantage for conventional SERS substrates.…”

mentioning

confidence: 99%

Ultrabroadband Metasurface for Efficient Light Trapping and Localization: A Universal Surface‐Enhanced Raman Spectroscopy Substrate for “All” Excitation Wavelengths

Zhang

Liu

et al. 2015

Adv Materials Inter

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nanoporous lithography methods, [18][19][20][21] etc. However, these techniques are still expensive and complicated for the fabrication of high quality SERS substrates over large areas, thus resulting in high prices for commercial SERS substrates. Furthermore, most commercial SERS substrates can only work for individual excitation wavelengths, i.e., one particular product works at one or two excitation wavelengths only. [22][23][24][25][26][27][28] When one wants to identify anonymous trace molecules or mixed samples, multiple excitation wavelengths will be required. [29][30][31] In this case, different substrates have to be used for different wavelength excitation, which consumes more biological/chemical materials, substrates, and measurement time. This is an obvious disadvantage for conventional SERS substrates. On the contrary, the SERS EF is proportional to the product of the fi eld intensity enhancements at both excitation and Raman scattering wavelengths. It was predicted that the maximum SERS enhancement can be achieved when localized surface plasmon resonance is located between the excitation and Raman scattering wavelengths. [ 32 ] To realize higher EF, double-resonance SERS substrates were proposed to realize strong enhancements for excitation and Raman scattered signals simultaneously using expensive e-beam lithography processes. [ 23 ] Due to the narrowband absorption spectra for both resonant bands, the enhanced SERS signal is still limited within narrow spectral regions. To address this problem, broadband resonant nanostructures are highly desired. For instance, a relatively broadband 1D metal-dielectric-metal metasurface (i.e., ≈70% optical absorption from 420 to 550 nm) was fabricated using e-beam lithography to realize uniform enhancement for SERS sensing. [ 24 ] However, the top-down lithography technique imposed a signifi cant fabrication cost barrier for large-scale practical applications. In addition, 1D grating structures are polarization dependent which can only work for given polarization states (usually transverse magnetic polarization). To overcome these limitations, here we report an ultrabroadband super absorbing metasurface substrate that can enhance the SERS signal for excitation wavelengths in a broad spectral region using lithography-free processes. [ 33 ] Most frequently used excitation wavelengths for SERS (e.g., from 450 to 1100 nm [23][24][25][26][27][28]34 ] are all covered due to the broadband light trapping and fi eld concentration within deep subwavelength Most reported surface-enhanced Raman spectroscopy (SERS) substrates can work for individual excitation wavelengths only. Therefore, different substrates have to be used for different excitation wavelengths, which consumes more biological/chemical materials, substrates, and measurement time. Here, an ultrabroadband super absorbing metasurface that can work as a universal substrate for low cost and high performance SERS sensing is reported. Due to broadband light trapping and localized fi eld enhancement, this structure can...

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“…This review summarizes current designs of SERS labels and highlights the underlying chemical and physical concepts relevant to central parameters such as sensitivity (optical/plasmonic properties; Section 2), multiplexing and quantication (Raman reporter molecules, Section 3), stability (encapsulation/protection, Section 4), and bioconjugation (Section 5). Applications of SERS for bioanalysis, including bioassays and biomedical imaging, have been summarized recently [29][30][31][32][33] and will therefore not be discussed here.…”

Section: Introductionmentioning

confidence: 99%

Rational design and synthesis of SERS labels

Wang

Schlücker

2013

Analyst

143

147

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SERS labels are a new class of nanotags for optical detection based on Raman scattering. Central advantages include their spectral multiplexing capacity due to the small line width of vibrational Raman bands, quantification based on spectral intensities, high photostability, minimization of autofluorescence from biological specimens via red to near-infrared (NIR) excitation, and the need for only a single laser excitation line. Current concepts for the rational design and synthesis of SERS labels are summarized in this review. Chemical constituents of SERS labels are the plasmonically active metal colloids for signal enhancement upon resonant laser excitation, organic Raman reporter molecules for adsorption onto the metal surface for identification, and an optional protective shell. Different chemical approaches towards the synthesis of rationally designed SERS labels are highlighted, including also their subsequent bioconjugation.

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Surface enhanced Raman scattering for multiplexed detection

Cited by 113 publications

References 62 publications

Graphene based metal and metal oxide nanocomposites: synthesis, properties and their applications

Graphene based metal and metal oxide nanocomposites: synthesis, properties and their applications

Ultrabroadband Metasurface for Efficient Light Trapping and Localization: A Universal Surface‐Enhanced Raman Spectroscopy Substrate for “All” Excitation Wavelengths

Rational design and synthesis of SERS labels

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