Surface modification of nylon‐6 fibers for medical applications

Abstract

Hydroxyethylmethacrylate (HEMA) is considered to be one of the important vinyl monomers. The ability of polyhydroxyethyl-methacylate (PHEMA) graft sites to consecutive chemical modification makes the use of nylon-6 fibers grafted with PHEMA a feasible bed for immobilization of a wide range of biologically active reagents, specially enzymes, drugs, cells, and immunadsorbents. Stemming from the above discussions, in this article, the graft copolymerization of HEMA onto modified nylon-6 fibers containing Polydiallyldimethylammonium chloride (PDADMAC) in the presence of Cu 2þ -K 2 S 2 O 8 as a redox initiating system was carried out, with very high rate and almost without homopolymer formation. The factors affecting the grafting reaction (monomer, K 2 S 2 O 8 and cupric ion concentrations, the amount of PDADMAC as well as the reaction temperature) were studied. Kinetic investigation revealed that the rate of grafting (R p ) of HEMA onto modified nylon-6 fibers is proportional to [HEMA] . The overall activation energy was calculated (71 KJ/mol). The fine structure, surface topography, thermal and electrical properties of parent and grafted nylon-6 fibers were investigated.

Grafting of 4‐Vinyl Pyridine onto Nylon‐6 Initiated by Redox System

“…6 •0.5H 2 O) was synthesized and measured according to the reported procedure. 10 To prepare the solution, the DPN of 0.1 mol•L -1 KOH and a little KIO 4 were added to 200 mL deionized water at 50 ℃ for about 2 h. Then, the mixture was cooled, and filtered through sintered glass crucible (G4). The concentration of DPN was obtained by its absorption using a Shimadzu UV-265 spectrophotometer (Japan).…”

“…There are some reports on grafting copolymerization of vinyl monomers onto nylon using Mn(III), Co(III), Fe(III), peroxomonosulfate-thioglycolic acid redox system, and electron-beam preirradiation technique. 4,6 Grafting polymerization is now considered as an effective method of adding certain desirable properties of PVP to nylon without greatly disturbing the strength and other mechanical properties of nylon. But most of reports about grafting 4VP to nylon are completed by traditional chain transfer methods which lead to lower grafting efficiency.…”

Enzymatic biofinishes for synthetic textiles

“…Recently the covalent attachment of bioactive compounds to functionalize polymer surfaces, including relevant techniques in polymer surface modifi cation such as wet chemical, organosilanization, ionized gas treatments and UV radiation, have been described (Shearer et al ., 2000 ;Goddard and Hotchkiss, 2007 ). Uses of synthetic polymers coated with bioactive compounds include applications in textile manufacturing, microelectronics, bioprocessing and medical and food packaging (Shalaby et al ., 2007 ).…”

Drug delivery systems using biotextiles

“…21 Often particular polymers cannot fulfi l all the desired properties, even after modifi cation. Thus the use of combined polymers may give the fi bers suffi cient tensile strength and fl exibility, while maintaining the desired drug release profi les and drug-loading properties.…”