Susceptibilities to 10 antimicrobial agents of 1,220 Campylobacter strains isolated from 1987 to 1993 from feces of pediatric patients

Abstract

We report the in vitro antibiotic susceptibility of 1,220 strains belonging to the thermotolerant Campylobacter species, isolated from the feces of pediatric patients with diarrhea in the period from 1987 to 1993. The strains were identified as 1,148 C.jejuni isolates and 72 C. coli isolates. The overall results show that the strains showed drug resistance as follows: 51.8% to ampicillin, 4.4% to clindamycin, 2.6% to chloramphenicol, 21.2% to tetracycline, and 1% to gentamicin. Twenty-one strains (1.7%) displayed resistance to the combination of amoxicillin-clavulanic acid, and 3.2% of the strains were resistant to erythromycin (MIC of .4 ,ug/ml), with a notable diference according to the species under consideration. While C. jejuni remained stable at 0.9 to 4% resistance to erythromycin, for C. coli the percentages detected ranged from 0 to 33%, with overall rates of 2.5 and 15.2% for the two species, respectively. Resistance to nalidixic acid (MIC of .32 ,ug/ml) was found in 27.2% of the strains (27.8% for C. jejuni and 18% for C. col), and resistance to ciprofloxacin (MIC of .4 ,Ig/ml) was found in 24.2% of the strains for C. jejuni and 15.2% for C. coli). Cross-resistance between nalidixic acid and ciprofloxacin was found in 89.1% of the strains (type 1 mutants), while 10.9% were resistant to nalidixic acid but susceptible to ciprofloxacin (type 2 mutants).

Antimicrobial resistance of thermophilic Campylobacter

“…Several studies have also shown an increase in the occurrence of macrolide resistance among Campylobacter causing infections in man [24,46,52]. The reason for the high frequency of macrolide resistance among C. coli from pigs has not been finally determined.…”

“…Intravenous aminoglycosides is the treatment of choice for serious Campylobacter bacteraemia and other systemic infections. However, increases in the occurrence of Campylobacter, causing infections in man, that are resistant to macrolides and fluoroquinolones, have been reported in several countries [13,16,24,45,46,52,55,57]. In these cases other antimicrobial agents may be used for treatment.…”

The Dynamics of Antimicrobial-Resistant Campylobacter jejuni on Japanese Broiler Farms

“…An increase in the number of Campylobacter isolates resistant to fluoroquinolone (FQ) in patients and animals has been reported [2,18,21,23,25,27,28]. Several epidemiological studies have indicated a relationship between the use of FQ in veterinary medicine and an increase in FQ-resistant Campylobacter [2,23,25].…”

Susceptibilidad antimicrobiana de Campylobacter jejuni aislado de coprocultivos en Santiago de Chile

“…Campylobacter es intrínsecamente resistente a penicilina G y cefalosporinas de primera generación debido a la débil unión de estos antimicrobianos con las proteínas de unión a penicilina (PBPs) 31 . Además, se ha descrito la adquisición de β-lactamasas como una causa importante de resistencia a β-lactámicos en esta bacteria [31][32][33] . En un estudio realizado por Tajada y cols, se determinó que de 100 cepas de C. jejuni y Campylobacter coli, 88% presentaban β-lactamasas y que, pese a la existencia de éstas, 77% de las cepas que las poseían eran susceptibles a amoxicilina 34 .…”