Symposium: Advances in Liver Pathology [<i>Abridged</i>]

Mn, Berry

doi:10.1177/003591576706001206

Cited by 35 publications

(2 citation statements)

References 32 publications

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“…Increased concentrations of lactic acid are known to be associated with liver malfunction and may also indicate increased tissue hypoxia and/or accelerated glycolysis. 15,16 Pyruvic acid, also associated with hyperlactatemia and hypoxia, was also positively associated with the HOMA-IR in the IDL fraction. Elevated levels of lactic and pyruvic acids in individuals with a high HOMA-IR index have also been observed in other studies.…”

Section: Discussionmentioning

confidence: 87%

Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance

et al. 2012

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While the molecular lipid composition of lipoproteins has been investigated in detail, little is known about associations of small polar metabolites with specific lipoproteins. The aim of the present study was to investigate the profiles of polar metabolites in different lipoprotein fractions, i.e., very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL) and two sub-fractions of the high-density lipoprotein (HDL). The VLDL, IDL, LDL, HDL(2), and HDL(3) fractions were isolated from serum of sixteen individuals having a broad range of insulin sensitivity and characterized using comprehensive two-dimensional gas chromatography combined with time-of-flight mass spectrometry (GC×GC-TOFMS). The lipoprotein fractions had clearly different metabolite profiles, which correlated with the particle size and surface charge. Lipoprotein-specific associations of individual metabolites with insulin resistance were identified, particularly in VLDL and IDL fractions, even in the absence of such associations in serum. The results indicate that the polar molecules are strongly attached to the surface of the lipoproteins. Furthermore, strong lipoprotein-specific associations of metabolites with insulin resistance, as compared to their serum profiles, indicate that lipoproteins may be a rich source of tissue-specific metabolic biomarkers.

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Section: Discussionmentioning

confidence: 87%

Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance

et al. 2012

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“…In humans, as in homofermentative bacteria, the lactate is produced by glycolysis using glucose to transform it into pyruvate and, by the action of the LDH, is converted into lactate by a reversible reaction with NADH as a coenzyme. In the human body, lactate is a waste product of anaerobic metabolisms and is used in gluconeogenesis to develop energy by oxidation in metabolic pathways like the Krebs cycle and Cory cycle; as a result, the skeletal muscle is the first consumer of lactate in the organism [54]. Also, the accumulation of lactate in the organisms, to be more specific, the accumulation of lactate in the blood, can bring consequences to the health and the generation of lactic acidosis [55][56][57].…”

Section: Metabolic Pathways and Biosynthesis Of The Lactic Acidmentioning

confidence: 99%

Recent advances in modified poly (lactic acid) as tissue engineering materials

et al. 2023

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As an emerging science, tissue engineering and regenerative medicine focus on developing materials to replace, restore or improve organs or tissues and enhancing the cellular capacity to proliferate, migrate and differentiate into different cell types and specific tissues. Renewable resources have been used to develop new materials, resulting in attempts to produce various environmentally friendly biomaterials. Poly (lactic acid) (PLA) is a biopolymer known to be biodegradable and it is produced from the fermentation of carbohydrates. PLA can be combined with other polymers to produce new biomaterials with suitable physicochemical properties for tissue engineering applications. Here, the advances in modified PLA as tissue engineering materials are discussed in light of its drawbacks, such as biological inertness, low cell adhesion, and low degradation rate, and the efforts conducted to address these challenges toward the design of new enhanced alternative biomaterials.

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Lactate Metabolism in Rat Lung Tissue

Tierney¹

1971

Arch Intern Med

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Symposium: Advances in Liver Pathology [Abridged]

Cited by 35 publications

References 32 publications

Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance

Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance

Recent advances in modified poly (lactic acid) as tissue engineering materials

Lactate Metabolism in Rat Lung Tissue

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