Synthese des Imidazolyl‐äthylamins

Windaus, A.; Vogt, Wilhelm

doi:10.1002/cber.190704003164

Cited by 131 publications

(45 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 1907, Windaus and Vogt [1] chemically synthesized and, in 1910, Ackermann [2] isolated histamine as a metabolite of bacterial histidine fermentation. Henry Dale, a young pharmacologist at Sir Wellcome's research laboratories in London, was working on ergot fungi extracts that were used for the treatment of postpartum bleeding.…”

Section: The Discovery Of Histaminementioning

confidence: 99%

Histamine Receptors and Antihistamines: From Discovery to Clinical Applications

Cataldi¹,

Borriello

Granata

et al. 2014

Chemical Immunology and Allergy

View full text Add to dashboard Cite

The synthesis and the identification of histamine marked a milestone in both pharmacological and immunological research. Since Sir Henry Dale and Patrick Laidlaw described some of its physiological effects in vivo in 1910, histamine has been shown to play a key role in the control of gastric acid secretion and in allergic disorders. Using selective agonists and antagonists, as well as molecular biology tools, four histamine receptors (H1R, H2R, H3R and H4R) have been identified. The Nobel Prize in Physiology and Medicine was awarded to Daniel Bovet in 1957 for the discovery of antihistamines (anti-H1R) and to Sir James Black in 1988 for the identification of anti-H2R antagonists. Anti-H1R and anti-H2R histamine receptor antagonists have revolutionized the treatment of certain allergic disorders and gastric acid-related conditions, respectively. More recently, anti-H3R antagonists have entered early-phase clinical trials for possible application in obesity and a variety of neurologic disorders. The preferential expression of H4R by several immune cells and its involvement in the development of allergic inflammation provide the rationale for the use of anti-H4R antagonists in allergic and in other immune-related disorders.

show abstract

Section: The Discovery Of Histaminementioning

confidence: 99%

Histamine Receptors and Antihistamines: From Discovery to Clinical Applications

Cataldi¹,

Borriello

Granata

et al. 2014

Chemical Immunology and Allergy

View full text Add to dashboard Cite

show abstract

“…Cloning and characterization of human histamine receptors was reported for the H 2 -receptor in 1991, the H 1 -receptor in 1993, the H 3 -receptor in 1999, and the H 4 -receptor in 2000. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] H 1 -antihistamines downregulate allergic inflammation directly through the H 1 -receptor by interfering with histamine action at H 1 -receptors on sensory neurons and small blood vessels. Through the ubiquitous transcription factor nuclear factor-kB, they also decrease antigen presentation, expression of proinflammatory cytokines and cell adhesion molecules, and chemotaxis.…”

Section: H 1 -Antihistaminesmentioning

confidence: 99%

Histamine and H1-antihistamines: Celebrating a century of progress

Simons

2011

Journal of Allergy and Clinical Immunology

462

373

View full text Add to dashboard Cite

“…[Histamine itself, like some other biogenic amines, was synthesized (Windaus and Vogt, 1907) before it was known to exist in nature.] The analogs are examined for their effects on tissues, and from the relative agonist activities, the receptors are tentatively classified.…”

mentioning

confidence: 99%