Syntheses of molecularly imprinted polymers: Molecular recognition of cyproheptadine using original print molecules and azatadine as dummy templates

Feás, Xesús; Seijas, Julio A.; Vázquez-Tato, M. Pilar; Regal, Patricia; Cepeda, Alberto; Fente, C.

doi:10.1016/j.aca.2008.10.054

Cited by 87 publications

(38 citation statements)

References 25 publications

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“…Currently, molecularly imprinted polymers (MIPs) as SPE sorbents have attracted considerable attention for ease of use and high binding selectivites [19]. However, the drawback of the MIP technique is the leakage of template molecules from the polymer matrix, which may cause false-positive results especially for trace analysis [20]. To overcome this problem, dummy templates, which are analogous to the target molecules, have been applied to design and synthesize "dummy molecularly imprinted polymers" (DMIPs).…”

Section: Introductionmentioning

confidence: 99%

Determination of hydroxylated polychlorinated biphenyls by offline solid-phase extraction-liquid chromatography–tandem mass spectrometry using a molecularly imprinted polymer as a sorbent for sample preconcentration

Liang

Zhao

et al. 2015

Talanta

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a b s t r a c tHydroxylated polychlorinated biphenyls (OH-PCBs) can be detected by liquid chromatography-mass spectrometry coupled to solid-phase extraction (SPE) using a dummy molecularly imprinted polymer (DMIP) as a sorbent. The DMIP is prepared by using an analogue of OH-PCBs (i.e., 4, 4-dihydroxybiphenyl) as a dummy template, to avoid the leakage of the target molecules. The DMIP-SPE sorbent shows good recoveries for OH-PCBs at pH 11 due to the charge-assisted hydrogen bondings between OH-PCBs and the DMIP. It has been found that the DMIP is much more effective and selective than the traditional C 18 -SPE method. The sample pH, polymer dosage, elution solvent and volume have been optimized for higher recoveries. Under the optimum experimental conditions, OH-PCBs can be detected in the linear concentration range of 0.05-1.0 pM, with the detection limits ranging from 11 fM to 82 fM for 4′-OH-CB 9, 4′-OH-CB 30, 4′-OH-CB 61, 4′-OH-CB 106 and 4′-OH-CB 112. The proposed system has been successfully applied to the determination of trace OH-PCBs in spiked water samples with recoveries in the range of 89-110%.

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Section: Introductionmentioning

confidence: 99%

Determination of hydroxylated polychlorinated biphenyls by offline solid-phase extraction-liquid chromatography–tandem mass spectrometry using a molecularly imprinted polymer as a sorbent for sample preconcentration

Liang

Zhao

et al. 2015

Talanta

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“…Several papers have reported the use of dummy template for the synthesis of MIP, although some results are good [14][15][16] but many others give low binding of MIP to the target [17][18]. Searching for dummy template can be determined directly using the analogue molecules, but it is not effective.…”

Section: Introductionmentioning

confidence: 99%

Computer Aided Design of Molecular Imprinted Polymer for Selective Recognition of Capsaicin

Tahir¹,

Wijaya²,

Islam³

et al. 2014

Indones. J. Chem.

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“…9, 2012 liquid-liquid extraction (LLE) and solid-phase extraction (SPE) have been proposed for the clean up step frequently. 6,7 LLE involves multiple time-consuming steps and requires large volumes of organic solvent which costs high and is dangerous to environment and human. Although SPE requires less solvent and shorter preparation time than LLE, SPE and its cartridges are also rather expensive.…”

Section: Introductionmentioning

confidence: 99%

Determination of ecstasy components in human urine by gas chromatography using a dispersive liquid-liquid microextraction procedure

Mashayekhi¹,

Rezaee²

2012

J. Braz. Chem. Soc.

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Um método novo foi desenvolvido para pré-concentração e determinação de compostos de ecstasy, 3,4-metilenodioxiamfetamina (MDA), 3,4-metilenodioximetilamfetamina (MDMA), 3,4-metilenodioxietilamfetamina (MDEA) e 3,4-metilenodioxipropilamfetamina (MDPA), em amostras de urina utilizando microextração líquido-líquido dispersiva (DLLME) e cromatografia gasosa com detector por ionização em chama (GC-FID). O método foi baseado na formação de gotículas de um extratante orgânico em soluções preparadas utilizando água, solvente orgânico imiscível (CS 2 ) dissolvido em solvente dispersor miscível em água (acetona). A fase orgânica, que extraiu MDA, MDEA, MDMA e MDPA da solução da amostra preparada, foi separada por centrifugação. Parâmetros que afetam a eficiência da extração foram investigados e otimizados. Sob condições ideais, as linearidades do método foram 1,0-500 µg L -1 para MDEA e MDPA e 2,5-500 µg L -1 para MDA e MDMA. . O método foi aplicado com sucesso na determinação de analitos em amostras de urina.A new method was developed for preconcentration and determination of ecstasy compounds, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethylamphetamine (MDMA), 3,4-methylenedioxyethylamphetamine (MDEA) and 3,4-methylenedioxypropylamphetamine (MDPA), in urine samples using dispersive liquid-liquid microextraction (DLLME) and gas chromatography (GC) with flame ionization detection (GC-FID). The method was based on the formation of tiny droplets of an organic extractant in prepared sample solution using water, immiscible organic solvent (CS 2 ) dissolved in water-miscible organic disperser solvent (acetone). The organic phase, which extracted MDA, MDEA, MDMA and MDPA from the prepared sample solution, was separated by centrifugation. Parameters affecting extraction efficiency were investigated and optimized. Under the optimum conditions, linearities of the method were 1.0-500 µg L -1 for MDEA and MDPA and 2.5-500 µg L -1 for MDA and MDMA. The limits of detection (LODs, S/N = 3, signal-to-noise ratio) were in the range from 0.3 to 0.8 µg L -1 . The method was successfully applied to the determination of analytes in urine samples.

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Syntheses of molecularly imprinted polymers: Molecular recognition of cyproheptadine using original print molecules and azatadine as dummy templates

Cited by 87 publications

References 25 publications

Determination of hydroxylated polychlorinated biphenyls by offline solid-phase extraction-liquid chromatography–tandem mass spectrometry using a molecularly imprinted polymer as a sorbent for sample preconcentration

Determination of hydroxylated polychlorinated biphenyls by offline solid-phase extraction-liquid chromatography–tandem mass spectrometry using a molecularly imprinted polymer as a sorbent for sample preconcentration

Computer Aided Design of Molecular Imprinted Polymer for Selective Recognition of Capsaicin

Determination of ecstasy components in human urine by gas chromatography using a dispersive liquid-liquid microextraction procedure

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