Synthesis and biological evaluation of decavanadate Na4Co(H2O)6V10O28·18H2O

Zhai, Fengying; Wang, Xiaohong; Li, Dongliu; Zhang, He; Li, Rui; Song, Liansheng

doi:10.1016/j.biopha.2008.01.006

Cited by 49 publications

(25 citation statements)

References 21 publications

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“…Many compounds containing [V 10 O 28 ] 6-cluster anions have been synthesized and their antibacterial activity [12] and antidiabetes activity [5] studied. However, there are few reports about their anticancer activity [13]. In order to gain some insights into the anticancer activity of compounds containing [V 10 O 28 ] 6-cluster anions, it is necessary to synthesize a series of decavanadate compounds of essentially the same decavanadate structure except for the cations.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structures and anticancer activities of two decavanadate compounds

Zhu

et al. 2010

Transition Met Chem

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Two ammonium decavanadate(V) compounds, (H 2 tmen) 3 V 10 O 28 Á6H 2 O (1) and (H 2 en) 3 V 10 O 28 Á2H 2 O (2), where H 2 tmen and H 2 en represent the doubly protonated N,N,N 0 ,N 0 -tetramethylethylenediammonium ion and doubly protonated ethylenediammonium ion, respectively, have been synthesized and structurally characterized by elemental analyses, spectroscopic (i.r., e.s.r.) studies, and single-crystal X-ray diffraction. Both crystal structures reveal the presence of the [V 10 O 28 ] 6-cluster anions, doubly protonated diammonium cations, and lattice water molecules. Hydrogen bonds assemble these two compounds to form three-dimensional networks. The in vitro anticancer activity against A549 and P388 tumor cells lines has also been determined by the MTT-based assay, and the results suggest that both compounds can inhibit proliferation of these two kinds of tumor cells.

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Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structures and anticancer activities of two decavanadate compounds

Zhu

et al. 2010

Transition Met Chem

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“…[4][5][6][7][8][9][10][11] Furthermore, the antidiabetic, anti-virus, anti-bacterial and anti-tumor activities of V 10 and vanadate compounds are attracting increasing interest. [12][13][14][15][16][17][18] Decavanadate also exhibits insulin-mimetic behavior, and it was shown that, upon incubation with decavanadate, rat adipocytes accumulate much more glucose than with well-established mimetic agents such as BMOV. 18 Decavanadate is in many cases likely a pro-drug, inducing anti-diabetic activity through peroxovanadate production.…”

Section: Introductionmentioning

confidence: 99%

Characterization of decavanadate and decaniobate solutions by Raman spectroscopy

et al. 2016

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The decaniobate ion, (Nb 10 = [Nb 10 O 28 ] 6− ) being isoelectronic and isostructural with the decavanadate ion (V 10 = [V 10 O 28 ] 6− ), but chemically and electrochemically more inert, has been useful in advancing the understanding of V 10 toxicology and pharmacological activities. In the present study, the solution chemistry of Nb 10 and V 10 between pH 4 and 12 is studied by Raman spectroscopy. The Raman spectra of V 10show that this vanadate species dominates up to pH 6.45 whereas it remains detectable until pH 8.59, which is an important range for biochemistry. Similarly, Nb 10 is present between pH 5.49 and 9.90 and this species remains detectable in solution up to pH 10.80. V 10 dissociates at most pH values into smaller tetrahedral vanadate oligomers such as V 1 and V 2 , whereas Nb 10 dissociates into Nb 6 under mildly (10 > pH > 7.6) or highly alkaline conditions. Solutions of V 10 and Nb 10 are both kinetically stable under basic pH conditions for at least two weeks and at moderate temperature. The Raman method provides a means of establishing speciation in the difficult niobate system and these findings have important consequences for toxicology activities and pharmacological applications of vanadate and niobate polyoxometalates.

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“…Previous studies have revealed that polyoxometalates are able to exert anticancer activities via regulation of invasion, proliferation and cell migration in a variety of malignancies, including breast (18), kidney (19), lung (19), ovary (20), pancreas (21) and prostate cancer (22). However, CrCuW 11 has not been reported to induce apoptosis in any human cancer cells.…”

Section: A B Discussionmentioning

confidence: 99%

Na7CrCuW11O39.16H2O induces apoptosis in human ovarian cancer SKOV3 cells through the p38 signaling pathway

et al. 2017

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Synthesis and biological evaluation of decavanadate Na4Co(H2O)6V10O28·18H2O

Cited by 49 publications

References 21 publications

Synthesis, crystal structures and anticancer activities of two decavanadate compounds

Synthesis, crystal structures and anticancer activities of two decavanadate compounds

Characterization of decavanadate and decaniobate solutions by Raman spectroscopy

Na7CrCuW11O39.16H2O induces apoptosis in human ovarian cancer SKOV3 cells through the p38 signaling pathway

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