Synthesis and Characterisation of Rice Husk Ash Silica Drug Carrier for α-Mangostin

Iqbal, Anwar; Shuib, Nur Azfa Muhammad; Darnis, Deny Susanti; Miskam, Mazidatulakmam; Rahman, Nur Ruzaina Abdul; Adam, Farook

doi:10.21315/jps2018.29.3.8

Cited by 6 publications

(8 citation statements)

References 11 publications

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“…A comparison of textural properties was made and summarized in Table 2 between the currently obtained results for MCM-48 and RHA and different properties for mesoporous silica having the same porous structure reported in previous works [4,14,20,22,[49][50][51]. The SA of the current MCM-48 was 1360.14 m 2 /g which was in the same magnitude as the reported values for MCM-48 [14,20,22], and MCM-41 [49].…”

Section: Resultssupporting

confidence: 72%

“…The Vp value of the current MCM-48 was 1.030 cm 3 /g, which was higher than the reported values for MCM-48 [14,20,22], MCM-41 [49], SBA-15 [50], and mesoporous silica-alumina [49]. Although, the Vp for the current RHA (0.292 cm 3 /g) was in the same range as the previously prepared RHA [4] and lower than the reported RHA obtained from the different origin [51].…”

Section: Resultscontrasting

confidence: 65%

“…65, No. SI:13B (2022) However, the SA of the current RHA was 147.51 m 2 /g which was approximately equal to the SA of the previously prepared RHA [4] and lower than the reported SA of RHA [51]. The Vp value of the current MCM-48 was 1.030 cm 3 /g, which was higher than the reported values for MCM-48 [14,20,22], MCM-41 [49], SBA-15 [50], and mesoporous silica-alumina [49].…”

Section: Resultsmentioning

confidence: 62%

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Comparative Study of Textural Properties for Various Silica by Nitrogen Adsorption-desorption Technique

Kurji

Abbas

Center³

2022

Egypt. J. Chem.

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This work studied the textual properties of the MCM-48 and rice husk ash using nitrogen adsorption-desorption at constant low temperatures. According to the International Union of Pure and Applied Chemistry, the adsorption-desorption isotherm proved that the studied materials have a mesoporous structure with type IV. The obtained results of Langmuir, Freundlich, and Brunauer-Emmett-Teller isotherm models showed that the nitrogen adsorption followed Brunauer-Emmett-Teller isotherm. The found adsorption capacity and surface area values for MCM-48 were higher than those values for rice husk ash. Based on the Kelvin equation, Barrett, Joyner, and Halenda model was used to determine pore size distribution, pore diameter, and average pore volume for the adsorbents. The pore size distribution for MCM-48 was narrower than rice husk ash, pore diameter for MCM-48 was less than rice husk ash, and average pore volume for MCM-48 was higher than the value of average pore volume for rice hush ash. The comparison study results between the properties and those previously published for mesoporous materials indicated a convergence in the surface area of MCM-48 and pore volume. Moreover, the results of the comparison between the properties of rice husk ash showed that the surface area and pore volume were equal or less than those obtained before.

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Section: Resultssupporting

confidence: 72%

Section: Resultscontrasting

confidence: 65%

Section: Resultsmentioning

confidence: 62%

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Comparative Study of Textural Properties for Various Silica by Nitrogen Adsorption-desorption Technique

Kurji

Abbas

Center³

2022

Egypt. J. Chem.

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“…The XRD patterns are displayed in Figure 3 . The AM showed sharp multiple peaks at 2θ of 5.4°, 11.6°, and 13.3°, which indicated a crystalline pattern [ 65 , 66 ], and the CS showed peaks at 10.4°, 19.7°, and 29.3° that exhibited semi-crystalline patterns [ 67 , 68 , 69 ]. The XRD spectrum of HA showed no specific diffraction pattern, indicating the amorphous nature of HA [ 64 ].…”

Section: Resultsmentioning

confidence: 99%

Hyaluronic Acid-Coated Chitosan Nanoparticles as an Active Targeted Carrier of Alpha Mangostin for Breast Cancer Cells

et al. 2023

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Alpha mangostin (AM) has potential anticancer properties for breast cancer. This study aims to assess the potential of chitosan nanoparticles coated with hyaluronic acid for the targeted delivery of AM (AM-CS/HA) against MCF-7 breast cancer cells. AM-CS/HA showed a spherical shape with an average diameter of 304 nm, a polydispersity index of 0.3, and a negative charge of 24.43 mV. High encapsulation efficiency (90%) and drug loading (8.5%) were achieved. AM released from AM-CS/HA at an acidic pH of 5.5 was higher than the physiological pH of 7.4 and showed sustained release. The cytotoxic effect of AM-CS/HA (IC50 4.37 µg/mL) on MCF-7 was significantly higher than AM nanoparticles without HA coating (AM-CS) (IC50 4.48 µg/mL) and AM (IC50 5.27 µg/mL). These findings suggest that AM-CS/HA enhances AM cytotoxicity and has potential applications for breast cancer therapy.

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“…As a result, the bioavailability of the drug increases [39]. The use of rice husk silica as the carrier of alphamangostin, via the sol-gel method, has been investigated and showed the changing of the crystal form of alpha-mangostin into amorphous form, increasing the solubility of alpha-mangostin [40].…”

Section: Amorphous Formationmentioning

confidence: 99%

Methods for Improving Alpha-Mangostin Solubility: A Review

2021

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Solubility is an important parameter to achieve for the bioavailability of a drug to reach the therapeutic windows. Garcinia mangostana Linn is a plant with great potency for the development of natural medicine. Alpha-mangostin is one of the secondary metabolites of G. mangostana and has been reported to have several pharmacological activities. The Biopharmaceutics Classification System (BCS) is a system that classifies drugs based on their solubility and permeability. Due to its low solubility but high permeation, alpha-mangostin is categorized into class II of the Biopharmaceutics Classification System. Therefore, the determination of dosage forms and modification of solubility enhancers is limited due to its physical properties, as mentioned above. This disadvantage requires new methods to improve its solubility to administer alpha-mangostin, especially for oral administration. Here, we discuss the development of the methods to increase alpha-mangostin solubility to be applied to formulate a dosage form to reach a useful plasma level for medication.

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Synthesis and Characterisation of Rice Husk Ash Silica Drug Carrier for α-Mangostin

Abstract: To cite this article: Iqbal, A. et al. (2018). Synthesis and characterisation of rice husk ash silica drug carrier for α-mangostin.

Cited by 6 publications

References 11 publications

Comparative Study of Textural Properties for Various Silica by Nitrogen Adsorption-desorption Technique

Comparative Study of Textural Properties for Various Silica by Nitrogen Adsorption-desorption Technique

Hyaluronic Acid-Coated Chitosan Nanoparticles as an Active Targeted Carrier of Alpha Mangostin for Breast Cancer Cells

Methods for Improving Alpha-Mangostin Solubility: A Review

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