Synthesis and in vitro study of methylene-bis-tetrahydro[1,3]thiazolo[4,5-c]isoxazoles as potential nematicidal agents

Facile synthesis of 5-bromotropono[${c}$]-fused pyrazoles and isoxazole

“…Additionally, in diversifying our work on new tropone-fused heterocyles, the same reaction conditions were further applied to the reaction with hydroxylamine hydrochloride (16) with the aim of constructing a novel tropone-fused isoxazole system as shown in Scheme 3. Interestingly, hydroxylamine hydrochloride was equally amenable to the conditions, only varying the reaction time according to TLC monitoring, and the corresponding 5-bromo-3-methyl-tropono[d]isoxazole (17) was obtained in a comparable yield of 70%.…”

“…In addition, as is well known, the ring-fused isoxazole skeleton is also an important structural unit that can be found in various bioactive compounds such as those with anti-HIV, 15 antifungal, 16 and nematicidal properties. 17 Accordingly, much work has been directed toward the design and synthesis of various ring-fused isoxazole derivatives.…”

Microwave-assisted Synthesis of Hybrid Heterocycles as Potential Anticancer Agents

“…Following the successful introduction of triazoles and thiazolidinones, microwave-assisted MCR reactions, inspired by the biological profile of triazoles, thiazolidinones, and in the continuation of our work on biologically active heterocycles [18][19][20][21][22][23][24][25][26][27][28][29] we have developed a series of novel triazole-linked thiazolidenone derivatives, we have investigated the application of microwave irradiation for the synthesis of our hybrid molecules and evaluated their anticancer activity.…”

Design, Synthesis of Biologically Active Heterocycles Containing Indol- Thiazolyl- Thiazolidinone Derivatives

“…Thiazolidinone ring also occurs in nature; thus actithiazic acid isolated from Streptomyces strains exhibit slightly specific in vitro activity against Mycobacterium tuberculosis [11]. Thiazolidinone derivatives are also known to exhibit diverse bioactivities such as anticonvulsant [12], antidiarrheal [13], anti-platelet activating factor (PAF) [14], antihistaminic [15], antidiabetic [16], cyclooxygenase inhibitory [17], Ca 2+ -channel blocker [18], PAF antagonist [19], cardioprotective [20], anti-ischemic [21], anticancer [22], tumor necrosis factor-α antagonist [23], and nematicidal activities [24]. The synthesis of heterocycles containing multi-structure in a molecule has received much attention in recent years [25].…”