Synthesis and spectroscopic properties of some new <i>N,N'</i>‐disubstituted thiorueas of potential biological interest

Sarkis, George Y.; Faisal, Essam D.

doi:10.1002/jhet.5570220134

Cited by 61 publications

(23 citation statements)

References 10 publications

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“…On the other hand, existence of the absorption peaks at 2452 and 1552 cm -1 in Fig. 1e can be attributed to S-H and C=N stretching vibrations, which indicates that the NH-C and C=S bands in the carbamothioyl section have resonances together and can form N=C and C-SH bands (thiol-thione tautomerism) [67][68][69].…”

Section: General Procedures For Preparation Of 34-dihydropyrimidin-2(mentioning

confidence: 99%

N-Propylcarbamothioyl benzamide complex of Bi(III) supported on superparamagnetic Fe3O4/SiO2 nanoparticles as a highly efficient and magnetically recoverable heterogeneous nanocatalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) via the Biginelli reaction

Mobinikhaledi

Foroughifar

Khajeh‐Amiri

2015

Reac Kinet Mech Cat

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The N-propylcarbamothioyl benzamide complex of Bi(III) immobilized on silica coated Fe 3 O 4 magnetic nanoparticles has been prepared as a highly efficient and recyclable heterogeneous nanocatalyst using simple processes for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a one-pot multicomponent condensation reaction of urea, aldehydes and b-dicarbonyl compounds under solvent-free conditions at 100°C. The structural and magnetic properties of the nanocatalyst were characterized using various techniques such as Fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy, thermogravimetric analysis, vibrating sample magnetometery and elemental analyses. Also, this nanocatalyst can be easily recovered by a magnetic field and reused for subsequent reactions for at least five times without deterioration in catalytic activity.

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Section: General Procedures For Preparation Of 34-dihydropyrimidin-2(mentioning

confidence: 99%

N-Propylcarbamothioyl benzamide complex of Bi(III) supported on superparamagnetic Fe3O4/SiO2 nanoparticles as a highly efficient and magnetically recoverable heterogeneous nanocatalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) via the Biginelli reaction

Mobinikhaledi

Foroughifar

Khajeh‐Amiri

2015

Reac Kinet Mech Cat

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“…We became interested in the synthesis of thiourea derivatives containing the pyrimidine moiety and their fused heterocyclic compounds (4a-d) by using Br 2 as the oxidant [23]. Moreover, these compounds contain an inherently weak NAS bond, which can benefit plant absorption and metabolism.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and pharmacological properties of N‐substituted‐N′‐(4,6‐dimethylpyrimidin‐2‐yl)‐thiourea derivatives and related fused heterocyclic compounds

Saeed

Rashid

Jones

et al. 2010

Journal of Heterocyclic Chem

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“…1,2 They possess antibacterial and antifungal activities [3][4][5] and can act as herbicides and rodenticides. 6,7 Till 1960, thiourea-based fungicides e.g., thiophanate and thiophanate-methyl were used extensively to various fruits and vegetable crops. 8 These compounds possess low acute toxicity for mammals and are very effective in preventing and curing a number of crop diseases.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antiviral Activities of Chiral Thiourea Derivatives

YAN¹,

Cai²,

Yang³

et al. 2009

Chin. J. Chem.

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An environmentally benign method has been developed for the synthesis of novel chiral thiourea derivatives in high yields in ionic liquid [Bmim]PF 6 . The ionic solvent can be recovered and reused without any loss of its activity. The target compounds were characterized by elemental analysis, IR, 1 H NMR and 13 C NMR spectral data. According to the preliminary bioassay, some of the chiral thiourea analogues exhibited moderate in vivo antiviral activities against TMV at a concentration of 500 mg/L. Title chiral compound 3i was found to possess good in vivo protection, inactivation and curative activities of 57.0%, 96.4% and 55.0%, respectively against TMV with an inhibitory concentration at 500 mg/L. The title chiral compound 3i revealed better inactivation effect on TMV (EC 50 ＝50.8 µg/mL) than Ningnanmycin (EC 50 ＝60.2 µg/mL).

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Synthesis and spectroscopic properties of some new N,N'‐disubstituted thiorueas of potential biological interest

Abstract: Thirty‐six new N,N'‐disubstituted thioureas have been synthesized by the reaction of phenyl‐, p‐fluorophenyl‐ and benzoylisothiocyanates with various substituted anilines, aminopyridines and 4‐aminoquinolines. The uv, ir and nmr spectral data are presented and discussed.

Cited by 61 publications

References 10 publications

N-Propylcarbamothioyl benzamide complex of Bi(III) supported on superparamagnetic Fe3O4/SiO2 nanoparticles as a highly efficient and magnetically recoverable heterogeneous nanocatalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) via the Biginelli reaction

N-Propylcarbamothioyl benzamide complex of Bi(III) supported on superparamagnetic Fe3O4/SiO2 nanoparticles as a highly efficient and magnetically recoverable heterogeneous nanocatalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) via the Biginelli reaction

Synthesis and pharmacological properties of N‐substituted‐N′‐(4,6‐dimethylpyrimidin‐2‐yl)‐thiourea derivatives and related fused heterocyclic compounds

Synthesis and Antiviral Activities of Chiral Thiourea Derivatives

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