Synthesis, characterization and anticancer studies of bis-(N-methyl-1-phenyldithiocarbamato) Cu(II), Zn(II), and Pt(II) complexes: single crystal X-ray structure of the copper complex

Synthesis, characterization and anti-cancer studies of Mn(II), Cu(II), Zn(II) and Pt(II) dithiocarbamate complexes - crystal structures of the Cu(II) and Pt(II) complexes

“…The intense bands observed at 1581 and 932 cm -1 in the FTIR spectrum of the free ligand were assigned to the thioureide ν(C-N) and ν(C-S) stretching vibrations of the N-CSS moiety and the broad band observed at 3361 cm -1 was assigned to ν(O-H). In the metal complexes, the ν(C-N) stretching vibrations shifted by 14 cm -1 to higher energies, which indicates an increase of the carbon-nitrogen double bond character [29,30,37]. The ν(C-S) stretching vibrations observed at 932 cm -1 in the ligand shifted to 956, 951, 951, and 948 cm -1 in the spectra of Mn(II), Cu(II), Zn(II) and Pt(II) complexes, respectively.…”

“…They inhibit NF-kB, which is known to promote tumor cell proliferation [26][27][28]. In continuation of our efforts to develop novel metallo drug candidates [3,29,30], we present the synthesis, characterization and in vitro anticancer studies of Mn(II), Cu(II), Zn(II) and Pt(II) complexes of 2-((ptolylamino)methyl)phenolyldithiocarbamate. The molecular structures of the Cu(II) and Pt(II) complexes are presented.…”

Synthesis, characterization, and anticancer activity of some azole‐heterocyclic complexes with gold(III), palladium(II), nickel(II), and copper(II) metal ions

“…Gold(III) complexes with chelating N‐donor ligands are the first gold(III) complexes examined for anticancer applications, in vitro pharmacological studies point out that some of these novel gold(III) complexes are highly cytotoxic toward cultured human tumor cell lines, pyridine‐based complexes were tested in vitro against a panel of cancer cell lines and HeLa cancer cells . Palladium(II), nickel(II), and copper(II) complexes also were very promising candidates for anticancer therapy, this idea was supported by a number of research articles relating the synthesis and cytotoxic activities of numerous Pd(II), Ni(II), and Cu(II) complexes …”

Gold(III) Complexes: An Overview on Their Kinetics, Interactions With DNA/BSA, Cytotoxic Activity, and Computational Calculations

“…The most common are complexes of copper, vanadium, ruthenium (Lazarević et al, 2017;Leon et al, 2017), rhodium (Chen et al, 2017), nickel, palladium (Jahromi et al, 2016), iron, cobalt, gold (Ott and Gust, 2007;Romero-Canelón and Sadler, 2013), and others. But, only a few of them, such as complexes of palladium(II), nickel(II), and copper(II), represent promising candidates for the treatment of cancer (Al-Masoudi et al, 2010;Andrew and Ajibade, 2018;Malik et al, 2018;Abdnoor and Albdali, 2019), while some of them, such as metalloid compound arsenic trioxide, are approved (Park et al, 2000;Miller et al, 2002). Namely, published results confirm the fact that metal complexes represent an arsenal with a wide and fundamental potential against cancer than small organic molecules (Luo et al, 2014;Rescifina et al, 2014;Alafeefy et al, 2015) due to possibility to change their properties with the right choice of oxidation state.…”