Synthesis, characterization and anticandidal activity of dioxomolybdenum(VI) complexes of the type [MoO2{ON=C(CH3)Ar}2] and [MoO2{OC(R)CHC(R’)=NC6H5}2]

Abstract

Interaction of [MoO 2 (acac) 2 ] with internally functionalized oximes like HON=C(CH 3 )Ar (Ar = C 4 H 3 S, C 4 H 3 O or C 5 H 4 N) and Schiff's Bases derived from β – diketones like HOC(R)CHC(R′)=NC 6 H 5 (R = R’ = CH 3 or C 6 H 5 ; R = CH 3 and R’ = C 6 H 5 ) led to the formation of yellow dioxomolybdenum(VI) complexes of the type [MoO 2 {ON=C(CH 3 )Ar} 2 ] and [MoO 2 {OC(R)CHC(R′)=NC 6 H 5 } 2 ]. Oximes were synthesized by green methodology. The newly synthesized complexes were characterized on basis of elemental analysis and various spectral findings. Anticandidal activity of [MoO 2 {ON=C(CH 3 )C 6 H 4 N} 2 ] clearly reveals that the complex is biologically active against fungal diseases.

Synthesis, characterization, and density functional theory studies of hydrazone–oxime ligand derived from 2,4,6‐trichlorophenyl hydrazine and its metal complexes searching for new antimicrobial drugs

“…The conductivity test of complexes (2-13) revealed that these complexes are nonelectrolytes with molar conductance ranging from 3.9-to 28.1 Ω −1 cm 2 mol −1 . [39] The analytical and spectral analyses data were provided in Section 2.3, showed that the complexes (2-4), (7)(8)(9)(10)(11) and (12)(13) were composed in molar ratio (1 L:1 M) while the complexes (5)(6) and (11) were composed in molar ratio (2 L:1 M), which is consistent with the proposed structures (Figures 2 and 3).…”

“…[78,79] The observed order for complex (10) g jj > g ⊥ confirmed that the unpaired electron is centralized in d x2 − y2 orbital and the geometry of this complex is SP and ruling out the probability of a TBP geometry that could be predicted to have g jj < g ⊥ . [78,80] The g values for Cu 2+ complexes (7)(8) and (10)(11) supported that they have one of the following geometries: an octahedral, square planar, or SP while the trend g jj > g ┴ > 2.0023 suggests that these geometries could be deformed. [81,82] The g value can be correlated to the parameter term of exchange interaction G by equation, G = (g jj − 2)/(g ┴ − 2).…”

“…These atoms have more electronegative charge assuring active sites for chelation. (iii) The estimated dipole moment value of the ligand (H 2 L) is 0.9668 while the calculated dipole moment values for complexes (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) are in the 6.03-21.97 Debye range: the comparison of the estimated values of the dipole moments for the ligand and complexes (2-12) indicating that dipole moment for these complexes are higher than the dipole moment for the free ligand. This may be due the chelation of metal ions with the ligand took place via nitrogen atoms of azomethine and oximato groups.…”

“…[78] According to Hathaway, if G is less than 4.0, a considerable exchange coupling is present, but if G more than 4.0, exchange coupling is negligible. The G values for complexes (7)(8) and (10)(11) ranged from 4.88 to 6.4, signifying that the exchange interaction between Cu 2+ ions is negligible. [83] Also the g jj /A jj values can serve as a diagnostic of stereochemistry.…”

“…Recently, compounds containing hydrazone and/or oxime linkage attracted the attention of many scholars because of their ability to form stable complexes with various transition metals, in addition to the presence of N-OH moiety, which could be enhance their chelation ability and make it more flexible in the reduction, oxidation, and conjugation with organic and inorganic compounds. These categories of compounds and their transition metal complexes showed biochemical [1] and bioactivity against pathogens resistant as antimicrobial, [2][3][4][5][6][7] antitumor, [3,4,8] anticancer, [9] anticandidal, [10] antitubercular, [11] antioxidant, and [4,12] anti-inflammatory analgesic [4,13] activities. Abdel-Aziz et al showed that the isoindoline-1,3-dione-based oximes and benzene-sulphonamide hydrazones have a selective inhibition of the tumor-associated carbonic anhydrase IX.…”