Synthesis, characterization and antimicrobial activity of new aliphatic sulfonamide

C5-Morpholinomethylation of N1-sulfonylcytosines by a one-pot microwave assisted Mannich reaction

“…4 On the other hand, sulfonyl moiety has been recognized as a potent pharmacophore in carbonic anhydrase and metalloprotease inhibitors, antifungal, antibacterial, antitumor and other biologically active compounds. 5,6 Since the sulfonyl-pyrimidines present an interesting combination of described pharmacophoric components, they have accordingly drawn quite attention of our research group.…”

Ecofriendly Synthesis in Aqueous Medium: An Expeditious Approach to New N,N-Diethyl Amide Bearing Benzenemethanesulfonamides

“…Some currently approved drugs and recently reported drug-like entities with sulfonamide structural skeletons are as shown in Fig. (1) below [4][5][6][7]. Although, arguably, the most direct route commonly used for synthesis of sulfonamides involves the nucleophilic attack of sulfonyl chloride by ammonia in the presence of a base [11].…”

“…Over the years, sulfonamides have been in clinical use [1,2] and are known to represent a class of medicinally important compounds [3][4][5] which are extensively used as antibacterial agents [6][7][8]. Sulfonamide has played a historically fundamental role in the advancement of structure-activity relationships [9] and potential utility of pharmacokinetics in drug design [10].…”

Synthesis, Antibacterial and Lipoxygenase Inhibition Studies of <i>N</i>-(Alkyl/aralkyl)-<i>N</i>-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-methylbenzenesulfonamides

“…15 Aliphatic sulfonamide derivatives act as antifungal agents. 16 Dioxane rings containing compounds can introduce variety of new substituents into common skeleton and provide new synthetic routes for generation of various organic compounds. These compounds have two special characteristics: (i) under thermal or photochemical conditions they are readily available for alkyletenes (ii) if C-C double bond is present in the dioxane ring then it will act as an enol form of masked acylacetic acids (unit cells in organic synthesis).…”