Synthesis, Characterization and Cytotoxicity of Certain Peg400 Based Biodegradable Aliphatic Copolyesters

Yamini, B.; Nanthini, R.

doi:10.31788/rjc.2018.1121992

Cited by 3 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antiproliferative effects and studies on cytotoxicity of aliphatic copolyesters are found in the literature. 41,42 The MTT analysis on cytotoxicity using HeLa cell viability based on products formed from polyester hydrolysis has been analyzed in detail by Kim, M. N. et al 43 In the present study on the aromatic copolyester, PTBI was analyzed employing HeLa (Cervical carcinoma) cell line following MTT assay with the routine procedure, the cells were seeded in 96 wells were cultured at 37°C along with 5% CO2. The given polyester samples in DMSO solution were diluted to 100 to 50 µg/mL with DMEM and were added to every culture well at a concentration of 50µM and incubated for 24h.…”

Section: Anticancer Study Mtt Assaymentioning

confidence: 95%

Synthesis and Studies on Aromatic Copolyester With Anticancer Activity Derived From 4,4’- Dihydroxybiphenyl and 3,5-Dihydroxytoluene

Sivaramakrishnan¹,

Elango²

2021

RJC

View full text Add to dashboard Cite

In this investigation, a new wholly aromatic random copolyester containing 4,4'-dihydroxybiphenyl, 3,5dihydroxytoluene and Isophthaloyl chloride was synthesized using the solution polycondensation methodology in the mole ratio 2:1:3 and its solubility along with inherent viscosity were determined. The chemical structure of the copolyester was established by traditional spectroscopic techniques. The physical parameters of the polyester were studied employing WAXD studies and the thermal stability along with phase transitions were investigated employing TGA and DSC data. The morphological features in the polyester were probed using Scanning Electron Microscopy. The anticancer activity of copolyester was verified using HeLa (Cervical carcinoma) cell line employing MTT assay.

show abstract

Section: Anticancer Study Mtt Assaymentioning

confidence: 95%

Synthesis and Studies on Aromatic Copolyester With Anticancer Activity Derived From 4,4’- Dihydroxybiphenyl and 3,5-Dihydroxytoluene

Sivaramakrishnan¹,

Elango²

2021

RJC

View full text Add to dashboard Cite

show abstract

“…The absorbance of each fraction against HCT 116 colon cancer cells was expressed as viability percentage. 13…”

Section: Mtt Assay Sample Screeningmentioning

confidence: 99%

CYTOTOXIC AND ANTIBACTERIAL ACTIVITIES OF MARINE SPONGE-DERIVED FUNGUS Aspergillus nomius NC06

Artasasta¹,

Yanwirasti²,

Bakhtiar³

et al. 2019

RJC

View full text Add to dashboard Cite

Sponge-derived fungi have attracted recent attention due to its important source of interesting biologically active compounds. In our previous study, we have obtained 13 fungi from marine sponge Neopetrsiachaliniformis. Among them, only Aspergillus nomius NC06 showed cytotoxic activity with the percentage of viability113.9 % and 70.31 % of Vero cell and WiDr colon cancer cell, respectively. This study aimed to isolate the cytotoxic compound from the ethyl acetate extract of N. nomius NC06 using chromatography method. A total of 5 fractions of the extract obtained using vacuum liquid chromatography. These fractions were tested against HCT 116 colon cancer cell and ten human pathogenic bacteria. Fraction II, III, IV, and V showed cytotoxic activity with IC 50 of 5. 28, 15.82, 10.27, and 45.57 µg/mL, respectively. In antibacterial testing, fraction II and III were potential because of their ability to inhibit the growth of ten pathogenic bacteria with the diameter of inhibition zone more than 12 mm.

show abstract

“…Previous research by Yamini and Nanthini (2018) showed that the attachment of succinic and sebacic acid on polyethylene glycol (PEG) 400 influenced the mechanical properties of the modified PEG 400 as well as the cytotoxic activity. 9 The mechanical properties of chitosan also can be improved by blending chitosan with sodium alginate. 10 The other alternative for reducing the toxicity of the anticancer agent is using the combination of a drug that can support the cytotoxic effect.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Cytotoxic Evaluation of Doxorubicin and Curcumin Analogue Loaded Modified Chitosan Nanoparticles

Sukmawati¹,

Nafarin²,

Yuliani³

et al. 2018

RJC

View full text Add to dashboard Cite

Chitosan had been successfully modified by conjugating with folic acid for specific delivery for an anticancer agent. The modified chitosan-folate (chitosan-FA) then prepared into a nanosize particle (NP) and loaded with the active substances, a combination of doxorubicin (DOX) and curcumin analog, 2,5-bis-(4-hydroxy,3,5-dimethyl benzylidene) cyclopentanone (Pentagamavunon-1, PGV-1). In this research, the cytotoxic activity of chitosan-FA NP containing the drugs against MCF-7 breast cancer cell was evaluated. The ionic gelation method was used for preparing of the chitosan-FA NP containing active substances. Physical characterization including particle size and zeta potential of the NP was analyzed using Particle Size Analyzer (PSA), whereas the encapsulation efficiency (EE) was analyzed using ultrafast liquid chromatography (UFLC). Anticancer activity of nanoparticles was carried out using the MTT method. The particle size obtained for chitosan-FA containing active substances was 111.8 ± 4.11 nm with the EE more than 75% for DOX and around 12% for PGV-1. The cytotoxic test with MTT assay showed that the DOX and PGV-1 loaded in chitosan-FA NP had anticancer activity against MCF-7 cells with IC50 value 25.8±2.55 µg/mL for DOX and 24.7±0.91 µg/mL for PGV-1 in combination.

show abstract

Synthesis, Characterization and Cytotoxicity of Certain Peg400 Based Biodegradable Aliphatic Copolyesters

Cited by 3 publications

References 28 publications

Synthesis and Studies on Aromatic Copolyester With Anticancer Activity Derived From 4,4’- Dihydroxybiphenyl and 3,5-Dihydroxytoluene

Synthesis and Studies on Aromatic Copolyester With Anticancer Activity Derived From 4,4’- Dihydroxybiphenyl and 3,5-Dihydroxytoluene

CYTOTOXIC AND ANTIBACTERIAL ACTIVITIES OF MARINE SPONGE-DERIVED FUNGUS Aspergillus nomius NC06

In Vitro Cytotoxic Evaluation of Doxorubicin and Curcumin Analogue Loaded Modified Chitosan Nanoparticles

Contact Info

Product

Resources

About