Synthesis, DNA binding, photo-induced DNA cleavage, cytotoxicity and apoptosis studies of copper(II) complexes

Binary and ternary new water soluble copper(II) complexes of l -tyrosine and substituted 1,10-phenanthrolines: Effect of substitution on DNA interactions and cytotoxicities

“…Electronic absorption spectroscopy is the most common and an important technique to explore the possible binding mode and binding strength of metal complexes to CT-DNA [62][63][64][65]. The interaction of dq-nphen, dq-phen and the complexes 1-4 with CT-DNA has been studied with UV spectroscopy to investigate the possible binding modes to CT-DNA and to calculate the binding constants (K b ) to CT-DNA.…”

Synthesis, spectroscopic characterization, X-ray structures, biological screenings, DNA interaction study and catalytic activity of organotin(IV) 3-(4-flourophenyl)-2-methylacrylic acid derivatives

“…3) hyperchromic effect. This suggests that HL binds with DNA double helix by hydrogen bonding between the ligand and the base pairs in DNA typically to N3 of adenine and O2 of thymine [60] resulting in bathochromism or classical electrostatic interaction due to protonated ligand [61]. While the organotin(IV) carboxylates 1 and 4 (Figs.…”

A copper(II) complex of the Schiff base from l-valine and 2-hydroxy-1-naphthalidene plus 1,10-phenanthroline: synthesis, crystal structure, and DNA interaction

“…Recently, design and synthesis of bio-essential amino acid Schiff base transition metal complexes, which are capable of binding to or cleaving DNA, have attracted much attention [7]. Copper is a bio-essential element with two biologically accessible oxidation states, and its amino acid Schiff base complexes have been synthesized and characterized due to the fact that copper(II) complexes can bring about not only oxidative cleavage of DNA but also hydrolytic photo-induced and electrolytic cleavage of DNA [8,9]. In our previous work, we have synthesized and structurally characterized some Schiff base complexes [10,11].…”