Synthesis of brushite nanoparticles at different temperatures

Abstract

Phase pure, stable nanocrystalline brushite particles with average diameter in the range of 23–87 nm were obtained by the reverse microemulsion technique employing a mixture of surfactants (Aliquat 336 & Tween 80) as template directing agents, and calcium nitrate tetrahydrate and biammonium hydrogen phosphate as precursors. Particle sizes and morphologies were tuned by adjusting the reaction parameters, precursor concentration and temperature. FTIR, TEM, and XRD were used to characterize morphological changes of as synthesized nanoparticles. FTIR and XRD analyses confirmed the formation of brushite nanoparticles. Variations in the reaction temperature resulted in changes in the particle morphology and distribution. At high temperatures (60°C), the sample exhibited high monodispersity and spherical morphology with the average grain size of 42 nm. At low temperatures (6°C), nanoflakes were formed. The results suggest that a reverse microemulsion system provides facile media for control of the phase and morphology of nanoscale calcium phosphate biominerals. A mechanism providing an insight into the formation of brushite particles has also been proposed.

Synthesis of spherical calcium phosphate particles for dental and orthopedic applications

“…For example, several authors have reported the production of spherical CaP particles with a diameter close to 15–20 nm, either by precipitation, 47 - 49 precipitation-emulsification, 50 , 51 spray-drying, 52 and flame-synthesis ( = flame pyrolysis) 53 - 55 (Table 2). The solutions may be either aqueous (precipitation, spray-drying), non-aqueous (precipitation, 56 flame-synthesis 57 - 60 ) or a mixture thereof (precipitation-emulsification 50 , 51 , 61 ). …”

Effect of preparation conditions on the nanostructure of hydroxyapatite and brushite phases

“…; monotite (DCPA) and brushite. A band at 989 cm -1 is assigned from the P-O(H) symmetric stretching vibration of PO 4 3-group (Singh et al 2010;Maity et al 2011). Moreover, band near to 1064 cm -1 is reffered to the m 3 stretching mode of the PO 4 3-group.…”

“…The bands at 3166, 3287, 3489 and 3542 cm -1 corresponded to stretching vibration of water [m s (O-H)] (Singh et al 2010;Ahmed et al 2014). The bands between 3000 and 3600 cm -1 show the presence of DCPD but not in its anhydrous form DCPA (Singh et al 2010;Zou et al 2012).…”

“…Therefore, this study is important for bio-mineralization phenomena (Singh et al 2010). Brushite is also important as soil phosphate fertilizer; it is relatively water soluble as compared with HAP (Pattanayak et al 2007).…”

“…Brushite is also important as soil phosphate fertilizer; it is relatively water soluble as compared with HAP (Pattanayak et al 2007). It can be used for supplying plant implants with the necessary amount of calcium phosphate (Singh et al 2010). The physical properties of calcium phosphate ceramics vary strongly according to particle shape, particle size, distribution and agglomeration (Ferreira et al 2003).…”