Synthesis of chitosan molecularly imprinted polymers for solid-phase extraction of methandrostenolone

Wang, Yun; Wang, Enlan; Wu, Ziming; Li, Huan; Zhu, Zhi; Zhu, Xiang; Dong, Ying

doi:10.1016/j.carbpol.2013.09.078

Cited by 96 publications

(37 citation statements)

References 31 publications

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“…Although SPE is the most convenient method for extraction due to its simplicity in terms of, labor intensive and solvent consuming, MISPE is currently a growing field in clean up techniques for the analysis of biological samples. SPE is a very common type of sample extraction and clean up technique for biological fluids in analytical chemistry [43][44][45][46][47].…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted polymer nanoparticles for olanzapine recognition: application for solid phase extraction and sustained release

et al. 2015

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Nowadays, polymeric nanoparticles have drawn more attention as drug carrier by investigators.In this study, we synthesized high selective imprinted nanoparticle polymer using olanzapine as template. The aim of this study was preparing efficient imprinted polymer nanoparticles from olanzapine as the template for the controlled release of olanzapine as a therapeutic drug for central nervous systems (CNS) disease at different pH values and the solid-phase extraction (SPE) as the sample clean-up technique combined with high-performance liquid chromatography (HPLC). The morphology of the nanoparticles was determined using scanning electron microscopy (SEM) images. Drug release, binding properties and dynamic light scattering (DLS) of the molecularly imprinted polymers (MIPs) were studied in this investigation. The adsorption isotherm was fitted with Langmuir and Freundlich models. The performance of the MIPs for the controlled release of olanzapine was assessed in two different media (SDS 1% and PBS). Results revealed that the MIPs have potential application in controlled drug release. Moreover, cytotoxicity of the MIP nanoparticles was measured on NIH/ 3 T3 cell line using MTT method.Furthermore, the MIPs were applied to extraction of olanzapine from human blood plasma samples. The limit of detection (LOD) and limit of quantification (LOQ) were evaluated and were 0.18 µg L -1 and 0.39 µg L -1 , respectively. These results collectively illustrate that MIP nanoparticles can be employed as an efficient technique for the extraction of the olanzapine from human plasma.

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Section: Introductionmentioning

confidence: 99%

Molecularly imprinted polymer nanoparticles for olanzapine recognition: application for solid phase extraction and sustained release

et al. 2015

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“…The use of modified natural and biodegradable polymeric backbones in the preparation of drug carriers is a common technique used by the most of researchers in this field . However, there are few works dealing with the combination of molecular imprinting technology and natural polymeric backbone‐based materials . Cellulose, as the most abundant polysaccharide produced in nature, has a linear β‐(1 → 4) linked glucan structure, enabling strong cooperative intra, and intermolecular hydrogen bond patterns that stiffens the chain and forms mechanically stable and insoluble fibrils and fibers .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of a cellulose‐based molecularly imprinted polymer in aqueous solution: The study of Furosemide slow release

2017

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In the present study, a green and biodegradable molecularly imprinted polymer (MIP) based on cellulose is introduced for Furosemide drug for the first time. Firstly sodium carboxymethyl cellulose (CMC) was synthesized from microcrystalline cellulose. Then the prepared CMC underwent cross‐linking in the drug pre‐assembly solution using 2‐hydroxyethyl methacrylate as the comonomer and ammonium peroxydisulfate as the CMC activating agent. The pre‐assembly solution of the drug was also prepared using Furosemide as the template molecule and acrylamide as the functional monomer in aqueous medium. The obtained results from binding and selectivity studies indicated the successful preparation of the CMC‐based MIP (CMC‐MIP) in aqueous solution. Besides, structural, thermal, and morphological characterization of the prepared system was investigated. In the final step, the in vitro release study of Furosemide from the synthesized polymers was carried out in pH = 7.41 phosphate buffered saline solution at 37°C. According to the results, the CMC‐MIP had a larger drug loading capacity and a higher amount of drug release at its equilibrium state compared to the corresponding non‐imprinted polymer (CMC‐NIP). Moreover, the drug release profiles showed that the drug release rate of the CMC‐MIP is more controlled than that of the CMC‐NIP, especially at the early stages of release.

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“…Although the MIPs prepared by conventional methods exhibit high selectivity, they still suffer from some intrinsic limitations, such as the heterogeneous distribution of the binding sites, the deep embedded binding sites in bulk and poor site accessibility for the template molecule [6]. In order to overcome these defections, MIPs based on various novel assisted matrices including silica [20], multi-walled carbon nanotubes [21,22], chitosan [23], Fe 3 O 4 magnetic nanoparticles [24] and quantum dot [3,25] have been prepared. Recently, surface molecularly imprinted polymers have attracted much attention for their advantages over the traditional MIPs, including adequate selectivity, more accessible binding sites, fast mass transfer rate and binding kinetics [26].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous preconcentration and determination of malachite green and fuchsine dyes in seafood and environmental water samples using nano-alumina-based molecular imprinted polymer solid-phase extraction

Mirzajani

Bagheban

2016

International Journal of Environmental Analytical Chemistry

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Molecular imprinted polymer for determination of malachite green (MG) and fuchsine basic (FU) dyes by spectrophotometry has been used, to develop a novel simultaneous extraction and preconcentration method. Molecularly imprinted layer-coated nano-alumina (MIP@Nano-Al 2 O 3 ) as adsorbent was prepared by surface molecular imprinting technique, and characterised by FTIR spectroscopy, scanning electron microscopy, energy dispersive X-ray analysis (EDAX) and thermogravimetric analysis (TGA). The method is based on simultaneous extraction of MG and FU dyes from aqueous solution by using molecularly imprinted polymer and measuring the absorbance at 617 and 546 nm for MG and FU, respectively. Parameters which affect the extraction efficiency such as pH, volume of eluent and amount of adsorbent were investigated and optimised. Linear calibration curves were obtained in the range of 2-750 ng mL −1 for MG and 1-240 ng mL −1 for FU under optimum conditions. Detection limit based on three times the standard deviation of the blank (3S b ) was 0.655 and 0.245 ng mL −1 (n = 10) for MG and FU, respectively. The relative standard deviation (RSD) for 100 ng mL −1 of MG and FU was 2.35 and 3.06% (n = 7), respectively. The method was applied to the simultaneous determination of the dyes in different seafood and environmental water samples. ARTICLE HISTORY

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Synthesis of chitosan molecularly imprinted polymers for solid-phase extraction of methandrostenolone

Cited by 96 publications

References 31 publications

Molecularly imprinted polymer nanoparticles for olanzapine recognition: application for solid phase extraction and sustained release

Molecularly imprinted polymer nanoparticles for olanzapine recognition: application for solid phase extraction and sustained release

Synthesis and characterization of a cellulose‐based molecularly imprinted polymer in aqueous solution: The study of Furosemide slow release

Simultaneous preconcentration and determination of malachite green and fuchsine dyes in seafood and environmental water samples using nano-alumina-based molecular imprinted polymer solid-phase extraction

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