Synthesis of poly(sulfobetaine methacrylate)-grafted chitosan under γ-ray irradiation for alamethicin assembly

Zhou, Yuan; Dong, Ping; Wei, Yanqi; Qian, Jun; Hua, Daoben

doi:10.1016/j.colsurfb.2015.05.019

Cited by 20 publications

(14 citation statements)

References 48 publications

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“…In all cases, the recorded values are very close to that of the reference sample where no material was added on the ASCs. Similar results have been found also from our group for other CS derivatives containing acrylates, such as poly(2-hydroxyethyl methacrylate) (PHEMA) [59] and 2-hydroxyethylacrylate [49], while the biocompatibility of CS-MEDSP derivative was also proved in a previous study reported in literature [50]. CS is a biocompatible polymer and can be used in biomedical and pharmaceutical applications.…”

Section: Synthesis Of Cs Derivativessupporting

confidence: 89%

“…Moreover, due to the low molar ratio of the used AAMPS and MEDSP monomers, the side chains on CS's backbone that consisted of AAMPS and MEDSP macromolecules did not form. The synthesis of /CS-MEDSP derivative was reported also in literature [50,51] but for a different kind of application than in our study, while CS-AAMPS derivative is synthesised for the first time. The chemical structures of the prepared derivatives are shown in Scheme 1.…”

Section: Synthesis Of Cs Derivativesmentioning

confidence: 65%

“…Furthermore, the low intensity peak at 10.5 • was not recorded in derivatives. The introduction of side groups in CS's macromolecular chains is well known that reduces their ability to fold and create crystallites, thus producing less crystalline [55,56] or completely amorphous derivatives [50]. This also occurs in the case of the produced CS-AAMPS and CS-MEDSP derivatives.…”

Section: Synthesis Of Cs Derivativesmentioning

confidence: 99%

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Chitosan Derivatives with Mucoadhesive and Antimicrobial Properties for Simultaneous Nanoencapsulation and Extended Ocular Release Formulations of Dexamethasone and Chloramphenicol Drugs

et al. 2020

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The aim of this work was to evaluate the effectiveness of neat chitosan (CS) and its derivatives with 2-acrylamido-2-methyl-1-propanesulfonic acid (AAMPS) and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (MEDSP) as appropriate nanocarriers for the simultaneous ocular administration of dexamethasone sodium phosphate (DxP) and chloramphenicol (CHL). The derivatives CS-AAMPS and CS-MEDSP have been synthesized by free-radical polymerization and their structure has been proved by Fourier-Transformed Infrared Spectroscopy (FT-IR) spectroscopy. Both derivatives exhibited low cytotoxicity, enhanced mucoadhesive properties and antimicrobial activity against Staphylococcus aureus (S.aureus) and Escherichia coli (E. coli). Encapsulation was performed via ionic crosslinking gelation using sodium tripolyphosphate (TPP) as the crosslinking agent. Dynamic light scattering measurements (DLS) showed that the prepared nanoparticles had bimodal distribution and sizes ranging from 50–200 nm and 300–800 nm. Drugs were encapsulated in their crystalline (CHL) or amorphous (DexSP) form inside nanoparticles and their release rate was dependent on the used polymer. The CHL dissolution rate was substantially enhanced compared to the neat drug and the release time was extended up to 7 days. The release rate of DexSP was much faster than that of CHL and was prolonged up to 3 days. Drug release modeling unveiled that diffusion is the main release mechanism for both drugs. Both prepared derivatives and their drug-loaded nanoparticles could be used for extended and simultaneous ocular release formulations of DexSP and CHL drugs.

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Section: Synthesis Of Cs Derivativessupporting

confidence: 89%

Section: Synthesis Of Cs Derivativesmentioning

confidence: 65%

Section: Synthesis Of Cs Derivativesmentioning

confidence: 99%

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Chitosan Derivatives with Mucoadhesive and Antimicrobial Properties for Simultaneous Nanoencapsulation and Extended Ocular Release Formulations of Dexamethasone and Chloramphenicol Drugs

et al. 2020

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“…Zhou and co-workers grafted poly(sulfobetaine methacrylate) on chitosan to yield polymer micelles through self-assembly. The antibiotic alamethicin interacts with these micelles forming a complex useful for controlled drug-release [18]. Further, Pasaphanet.…”

Section: Introductionmentioning

confidence: 99%

Graft-Copolymerization of Acrylate Monomers onto Chitosan Induced by Gamma Radiation: Amphiphilic Polymers and Their Behavior at The Air-Water Interface

Caldera‐Villalobos

Leal-Acevedo

Velázquez-Aguilar

et al. 2020

J. Nucl. Phy. Mat. Sci. Rad. A.

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Graft polymerization induced by ionizing radiation is a powerful tool in materials science to modifying the physical properties of polymers. Chitosan is a biocompatible, biodegradable, antibacterial, and highly hydrophilic polysaccharide. In this work, we report the obtaining of amphiphilic polymers through graft polymerization of acrylic monomers (methyl acrylate, t-butyl acrylate, and hexyl acrylate) onto chitosan. The polymerization reaction was carried out by simultaneous irradiation of monomers and chitosan using a gamma radiation source of 60Co. The formation of Langmuir films of amphiphilic polymers was studied at the air-water interface through surface pressure versus main molecular area isotherms (Π-A) and hysteresis cycles of compression and decompression. Finally, it was analyzed the transferring of Langmuir films towards solid substrates to obtaining Langmuir-Blodgett films with potential application as an antibacterial coating. The microstructure of the Langmuir-Blodgett films was characterized by AFM microscopy observing a regular topography with roughness ranging between 0.53 and 0.6 μm.

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“…In addition, the degree of grafting can be easily controlled by the radiation dose. 19,20 Chemical-free grafting methods (high-energy radiation including microwaves, UV and/or gamma rays, and electron beams) have been used to produce safe and highly efficiency products. [21][22][23] Among them, gamma-ray irradiation shows the most potential for synthesizing grafted copolymers, given its simplicity, high-energy emission, non-thermal process, and lower cost.…”

mentioning

confidence: 99%

One-step synthesis of gene carrier via gamma irradiation and its application in tumor gene therapy

Jeong¹,

Park²,

Park³

et al. 2018

IJN

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Introduction Although numerous studies have been conducted with the aim of developing drug-delivery systems, chemically synthesized gene carriers have shown limited applications in the biomedical fields due to several problems, such as low-grafting yields, undesirable reactions, difficulties in controlling the reactions, and high-cost production owing to multi-step manufacturing processes. Materials and methods We developed a 1-step synthesis process to produce 2-aminoethyl methacrylate-grafted water-soluble chitosan (AEMA-g-WSC) as a gene carrier, using gamma irradiation for simultaneous synthesis and sterilization, but no catalysts or photoinitiators. We analyzed the AEMA graft site on WSC using 2-dimensional nuclear magnetic resonance spectroscopy (2D NMR; 1 H and 13 C NMR), and assayed gene transfection effects in vitro and in vivo. Results We revealed selective grafting of AEMA onto C6-OH groups of WSC. AEMA-g-WSC effectively condensed plasmid DNA to form polyplexes in the size range of 170 to 282 nm. AEMA-g-WSC polyplexes in combination with psi-hBCL2 (a vector expressing short hairpin RNA against BCL2 mRNA) inhibited tumor cell proliferation and tumor growth in vitro and in vivo, respectively, by inducing apoptosis. Conclusion The simple grafting process mediated via gamma irradiation is a promising method for synthesizing gene carriers.

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Synthesis of poly(sulfobetaine methacrylate)-grafted chitosan under γ-ray irradiation for alamethicin assembly

Cited by 20 publications

References 48 publications

Chitosan Derivatives with Mucoadhesive and Antimicrobial Properties for Simultaneous Nanoencapsulation and Extended Ocular Release Formulations of Dexamethasone and Chloramphenicol Drugs

Chitosan Derivatives with Mucoadhesive and Antimicrobial Properties for Simultaneous Nanoencapsulation and Extended Ocular Release Formulations of Dexamethasone and Chloramphenicol Drugs

Graft-Copolymerization of Acrylate Monomers onto Chitosan Induced by Gamma Radiation: Amphiphilic Polymers and Their Behavior at The Air-Water Interface

One-step synthesis of gene carrier via gamma irradiation and its application in tumor gene therapy

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