Synthesis of surfactant‐modified ZIF‐8 with controllable microstructures and their drug loading and sustained release behaviour

Xu, Xinyu; Liu, Ye; Guo, Zhaoming; Song, Xue‐Zhi; Qi, Xiuyu; Dai, Zideng; Tan, Zhenquan

doi:10.1049/iet-nbt.2020.0076

Cited by 15 publications

(12 citation statements)

References 39 publications

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“…In the particular case of biodegradable materials, the topography of a surface can be modified as a result of degradation in physiological media [41][42][43], especially if the materials are loaded with substances that are very active or reactive in aqueous media, as is the case of magnesium [7,44] and surfactants [23,45]. Particularly, in contact with water, magnesium forms a hydroxide, soluble up to pH = 10.5, and precipitates above this pH value.…”

Section: Introductionmentioning

confidence: 99%

Micro-structured and self-assembled patterns in PLA-cast films as a function of CTAB content, magnesium and substratum hydrophobicity

Gallardo-Moreno

Luque-Agudo

González-Martı́n

et al. 2022

Applied Surface Science

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Section: Introductionmentioning

confidence: 99%

Micro-structured and self-assembled patterns in PLA-cast films as a function of CTAB content, magnesium and substratum hydrophobicity

Gallardo-Moreno

Luque-Agudo

González-Martı́n

et al. 2022

Applied Surface Science

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“…MIL100 can release Fe ions in solution to consume GSH. The quantitative analysis of the iron by inductively coupled plasma‐optical emission spectroscopy (ICP‐OES) shows that there is more Fe was released from MIL100 with GSH compared with that without GSH (Figure 2b), indicating that MIL100 can release Fe trough the reaction with GSH [31] . The UV‐vis absorption spectrum also shows that the concentration of the GSH decrease with the increase of the MIL100 concentration (Figure 2c), indicating that GSH can react with the MIL100 [32] …”

Section: Resultsmentioning

confidence: 99%

An Fe‐MIL100 Based Drug Delivery System for pH and Glutathione Dual‐Responsive Drug Release

Song

et al. 2021

ChemistrySelect

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Fe-MIL100 with high Fe(II) content is synthesized at room temperature via a green synthesis process and used to form drug delivery system DOX@PEG-MIL100 by loading doxorubicin (DOX) and coating with polyethyleneglycol (PEG). This drug delivery system shows pH and glutathione (GSH) dualresponsive drug release behavior in response to tumor microenvironment and a high cytotoxicity in tumor cell line.

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“…MiR-491-5p needs an effective targeted carrier to enter cells. The ZIF-8 structure has good thermal stability, a simple synthesis method, tumor site stability, and a special acid response, and many studies have reported ZIF-8 as a drug delivery carrier in cancer therapy ( Fatima et al, 2020 ; Xu et al, 2020 ; Wu et al, 2021 ). In this study, a ZIF-8 nanodrug carrier was synthesized and loaded with miR-491-5p.…”

Section: Discussionmentioning

confidence: 99%

“…The zeolite imidazolate framework-8 (ZIF-8) structure has good thermal stability, a simple synthesis method, tumor site stability, and special acid responsiveness, which provides a very obvious advantage for its application in the field of tumor diagnosis and treatment. Many studies have reported ZIF-8 as a drug delivery carrier in cancer therapy ( Fatima et al, 2020 ; Xu et al, 2020 ; Wu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Folic Acid–Modified miR-491-5p–Loaded ZIF-8 Nanoparticles Inhibit Castration-Resistant Prostate Cancer by Regulating the Expression of EPHX1

Liu

et al. 2021

Front. Bioeng. Biotechnol.

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Epoxide hydrolase 1 (EPHX1) has been reported to be related to the development of several tumors. However, the regulation of castration-resistant prostate cancer (CRPC) development by EPHX1 has not been reported. We used proteomic technology and found that the EPHX1 protein was highly expressed in CRPC tissues and the CRPC cell line C4-2. We performed screening and found that EPHX1 is a direct target of miR-491-5p. High miR-491-5p expression significantly reduced the EPHX1 level in C4-2 cells and inhibited C4-2 cell proliferation and migration. Zeolite imidazolate framework-8 (ZIF-8) has good thermal stability, a simple synthesis method, tumor site stability, and specific acid responsiveness. We synthesized ZIF-8 nanodrug vectors to deliver miR-491-5p into C4-2 cells. After loading miR-491-5p into ZIF-8, we modified the ZIF-8 surface with folic acid (FA) as the target group (FA@ZIF-8). Our synthesized nanodrug carrier showed less cytotoxicity to C4-2 cells even at 200 μg/ml. Modified FA could increase the efficiency of nanomaterial entry into C4-2 cells. FA@miR-491-5p@ZIF-8 could stably release miR-491-5p for a long period in both phosphate-buffered saline (pH 7.4) and acetate buffer (pH 4.8), and miR-491-5p was released faster at the beginning of the experiment in acetate buffer (pH 4.8). FA@miR-491-5p@ZIF-8 significantly reduced C4-2 cell proliferation and migration, and FA@miR-491-5p@ZIF-8 had a better effect than miR-491-5p alone. In vivo, FA@miR-491-5p@ZIF-8 significantly inhibited CRPC growth in nude mice. Overall, we verified that miR-491-4p regulated CRPC development by targeting EPHX1. The drug nanocarrier FA@miR-491-5p@ZIF-8 not only significantly reduced C4-2 CRPC cell proliferation and migration but also significantly inhibited CRPC growth. Our research provides a theoretical basis for treatment and treatment strategies for CRPC.

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Synthesis of surfactant‐modified ZIF‐8 with controllable microstructures and their drug loading and sustained release behaviour

Cited by 15 publications

References 39 publications

Micro-structured and self-assembled patterns in PLA-cast films as a function of CTAB content, magnesium and substratum hydrophobicity

Micro-structured and self-assembled patterns in PLA-cast films as a function of CTAB content, magnesium and substratum hydrophobicity

An Fe‐MIL100 Based Drug Delivery System for pH and Glutathione Dual‐Responsive Drug Release

Folic Acid–Modified miR-491-5p–Loaded ZIF-8 Nanoparticles Inhibit Castration-Resistant Prostate Cancer by Regulating the Expression of EPHX1

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