Synthesis of α-Amino Phosphonates under a Neat Condition Catalyzed by Multiple-Acidic Ionic Liquids

Abstract

A simple and efficient method for the synthesis of α-amino phosphonates has been accomplished from aromatic aldehydes, diethyl phosphite, and aromatic amines using multiple-acidic ionic liquids catalysts under solvent-free conditions at room temperature, and these compounds were characterized by H–H correlation spectroscopy (COSY).

Ionic Modified TBD Supported on Magnetic Nanoparticles: A Highly Efficient and Recoverable Catalyst for Organic Transformations

“…Because of the unique properties of low vapor pressure, wide liquid range, high thermal stability, excellent dissolution ability, − ionic liquids (ILs) have been introduced as linker into the structures of heterogeneous catalysts. To some surprise, the ionic moiety in the catalyst can more or less stabilize the transition state of reaction through electrosteric activitaion, which is benificial to reaction rate as well as reaction chem- and stereo-selectivity. − 1,5,7-Triazabicyclo[4.4.0]­dec-5-ene (TBD), a basic guanidine, is widely used as promoter or catalyst in organic synthesis. − Combining the advantages of magnetic nanoparticles and ionic liquids and continuation of effort in the development of environmentally benign protocols, − we design a novel ionic modified TBD grafted on the MNPs (Scheme ) and its application in the synthesis of N , N -substituted ureas as well as aza-Michael addtion.…”

Recent Advances in the Synthesis of α‐Aminophosphonates: A Review

“…The model reaction performed as shown in (Scheme 12) employing 5; 10; 15 or 20 mol% of various ionic liquids at room temperature. [62] SFHEA The recyclability test showed that decreased in the yield of product from 91 % (1st round) to 87 % (5th round).…”

“… Functionalized Hydroxy‐Ethyl Amine ionic liquids tested as a catalyst for the synthesis of ‐Aminophosphonates. The model reaction performed as shown in (Scheme 12 ) employing of various ionic liquids at room temperature [62] …”

A novel hydrophobic copper complex supported on γ‐Fe2O3 as a magnetically heterogeneous catalyst for one‐pot three‐component synthesis of α‐aminophosphonates

“…Their biological applications as herbicides, fungicides, enzyme inhibitors, plant growth regulators, antitumor, antibiotics, peptide mimics, antiviral and pharmacological agents are well documented. These enormous applications have encouraged the development of a number of techniques for the synthesis of α‐aminophosphonates . Kabachnik‐Fields reaction is one of the most direct and efficient routes for the synthesis of α‐aminophosphonates.…”