Synthesis, photophysical and theoretical studies of substituted ethyl 4-(3-(naphthalen-1-yl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)benzoate

Synthesis of Pyrazoline Derivatives and Their Pharmacological Activities: A Review of the Last Decade

“…Several other methods have been used for the synthesis of pyrazoline, i. e. (1) 1,3 dipolar cyclo addition, [6] (2) α, β-epoxy ketone with phenyl hydrazine derivative [7] (3) α, β-unsaturated ester with diazomethane or trimethylsilyl diazomethane [8] (4) α, β-unsaturated nitrile with hydrazine derivative [9] (5) unsaturated hydrazone with copper acetate [10] (6) α, β-unsaturated carbonyl compound or 1,3 dicarbonyl compound with hydrazine derivative. [11] They also possess several biological properties such as antibacterial, [12] antifungal, [13] anticancer, [14] antipyretic, antimalarial, antitubercular, [15] antidepressant, and antiinflammatory, [16] as well as non-biological applications in solar dyes, chemosensors, [17] photoconductors, and optoelectronic devices. [18] Literature surveys reveal many synthetic methods of pyrazoline derivative like conventional, heterogeneous catalyzed, and noncatalyzed methods and the presence of this core in many molecules enhances the biological activity.…”